α-2,3-Sialyltransferase Expression Level Impacts the Kinetics of Lipooligosaccharide Sialylation, Complement Resistance, and the Ability of <named-content content-type="genus-species">Neisseria gonorrhoeae</named-content> to Colonize the Murine Genital Tract

ABSTRACT  Neisseria meningitidis and Neisseria gonorrhoeae modify the terminal lacto-N-neotetraose moiety of their lipooligosaccharide (LOS) with sialic acid. N. gonorrhoeae LOS sialylation blocks killing by complement, which is mediated at least in part by enhanced binding of the complement inhibit...

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Auteurs principaux: Lisa A. Lewis, Sunita Gulati, Elizabeth Burrowes, Bo Zheng, Sanjay Ram, Peter A. Rice
Format: article
Langue:EN
Publié: American Society for Microbiology 2015
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Accès en ligne:https://doaj.org/article/0dbc73670e9a4906bfb606cfedd54323
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