Development of brain atlases for early-to-middle adolescent collision-sport athletes

Abstract Human brains develop across the life span and largely vary in morphology. Adolescent collision-sport athletes undergo repetitive head impacts over years of practices and competitions, and therefore may exhibit a neuroanatomical trajectory different from healthy adolescents in general. Howev...

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Autores principales:	Yukai Zou, Wenbin Zhu, Ho-Ching Yang, Ikbeom Jang, Nicole L. Vike, Diana O. Svaldi, Trey E. Shenk, Victoria N. Poole, Evan L. Breedlove, Gregory G. Tamer, Larry J. Leverenz, Ulrike Dydak, Eric A. Nauman, Yunjie Tong, Thomas M. Talavage, Joseph V. Rispoli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0dbda15dc83540f78257831fff8c7e21
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spelling	oai:doaj.org-article:0dbda15dc83540f78257831fff8c7e212021-12-02T17:04:59ZDevelopment of brain atlases for early-to-middle adolescent collision-sport athletes10.1038/s41598-021-85518-62045-2322https://doaj.org/article/0dbda15dc83540f78257831fff8c7e212021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85518-6https://doaj.org/toc/2045-2322Abstract Human brains develop across the life span and largely vary in morphology. Adolescent collision-sport athletes undergo repetitive head impacts over years of practices and competitions, and therefore may exhibit a neuroanatomical trajectory different from healthy adolescents in general. However, an unbiased brain atlas targeting these individuals does not exist. Although standardized brain atlases facilitate spatial normalization and voxel-wise analysis at the group level, when the underlying neuroanatomy does not represent the study population, greater biases and errors can be introduced during spatial normalization, confounding subsequent voxel-wise analysis and statistical findings. In this work, targeting early-to-middle adolescent (EMA, ages 13–19) collision-sport athletes, we developed population-specific brain atlases that include templates (T1-weighted and diffusion tensor magnetic resonance imaging) and semantic labels (cortical and white matter parcellations). Compared to standardized adult or age-appropriate templates, our templates better characterized the neuroanatomy of the EMA collision-sport athletes, reduced biases introduced during spatial normalization, and exhibited higher sensitivity in diffusion tensor imaging analysis. In summary, these results suggest the population-specific brain atlases are more appropriate towards reproducible and meaningful statistical results, which better clarify mechanisms of traumatic brain injury and monitor brain health for EMA collision-sport athletes.Yukai ZouWenbin ZhuHo-Ching YangIkbeom JangNicole L. VikeDiana O. SvaldiTrey E. ShenkVictoria N. PooleEvan L. BreedloveGregory G. TamerLarry J. LeverenzUlrike DydakEric A. NaumanYunjie TongThomas M. TalavageJoseph V. RispoliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yukai Zou Wenbin Zhu Ho-Ching Yang Ikbeom Jang Nicole L. Vike Diana O. Svaldi Trey E. Shenk Victoria N. Poole Evan L. Breedlove Gregory G. Tamer Larry J. Leverenz Ulrike Dydak Eric A. Nauman Yunjie Tong Thomas M. Talavage Joseph V. Rispoli Development of brain atlases for early-to-middle adolescent collision-sport athletes
description	Abstract Human brains develop across the life span and largely vary in morphology. Adolescent collision-sport athletes undergo repetitive head impacts over years of practices and competitions, and therefore may exhibit a neuroanatomical trajectory different from healthy adolescents in general. However, an unbiased brain atlas targeting these individuals does not exist. Although standardized brain atlases facilitate spatial normalization and voxel-wise analysis at the group level, when the underlying neuroanatomy does not represent the study population, greater biases and errors can be introduced during spatial normalization, confounding subsequent voxel-wise analysis and statistical findings. In this work, targeting early-to-middle adolescent (EMA, ages 13–19) collision-sport athletes, we developed population-specific brain atlases that include templates (T1-weighted and diffusion tensor magnetic resonance imaging) and semantic labels (cortical and white matter parcellations). Compared to standardized adult or age-appropriate templates, our templates better characterized the neuroanatomy of the EMA collision-sport athletes, reduced biases introduced during spatial normalization, and exhibited higher sensitivity in diffusion tensor imaging analysis. In summary, these results suggest the population-specific brain atlases are more appropriate towards reproducible and meaningful statistical results, which better clarify mechanisms of traumatic brain injury and monitor brain health for EMA collision-sport athletes.
format	article
author	Yukai Zou Wenbin Zhu Ho-Ching Yang Ikbeom Jang Nicole L. Vike Diana O. Svaldi Trey E. Shenk Victoria N. Poole Evan L. Breedlove Gregory G. Tamer Larry J. Leverenz Ulrike Dydak Eric A. Nauman Yunjie Tong Thomas M. Talavage Joseph V. Rispoli
author_facet	Yukai Zou Wenbin Zhu Ho-Ching Yang Ikbeom Jang Nicole L. Vike Diana O. Svaldi Trey E. Shenk Victoria N. Poole Evan L. Breedlove Gregory G. Tamer Larry J. Leverenz Ulrike Dydak Eric A. Nauman Yunjie Tong Thomas M. Talavage Joseph V. Rispoli
author_sort	Yukai Zou
title	Development of brain atlases for early-to-middle adolescent collision-sport athletes
title_short	Development of brain atlases for early-to-middle adolescent collision-sport athletes
title_full	Development of brain atlases for early-to-middle adolescent collision-sport athletes
title_fullStr	Development of brain atlases for early-to-middle adolescent collision-sport athletes
title_full_unstemmed	Development of brain atlases for early-to-middle adolescent collision-sport athletes
title_sort	development of brain atlases for early-to-middle adolescent collision-sport athletes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0dbda15dc83540f78257831fff8c7e21
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Development of brain atlases for early-to-middle adolescent collision-sport athletes

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