Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia
Studies with patient derived xenografts are hampered by factors such as genetic variability and sample availability. Here, the authors generate a leukemia mouse model by lentiviral transduction of normal human cord blood and show an oncogenic role of HOXB genes.
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Nature Portfolio
2019
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oai:doaj.org-article:0dc063f01a744a6691471a7f27cd84dc2021-12-02T16:57:31ZSynthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia10.1038/s41467-019-10510-82041-1723https://doaj.org/article/0dc063f01a744a6691471a7f27cd84dc2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10510-8https://doaj.org/toc/2041-1723Studies with patient derived xenografts are hampered by factors such as genetic variability and sample availability. Here, the authors generate a leukemia mouse model by lentiviral transduction of normal human cord blood and show an oncogenic role of HOXB genes.Manabu KusakabeAnn Chong SunKateryna TyshchenkoRachel WongAastha NandaClaire ShannaSamuel GusscottElizabeth A. ChavezAlireza LorzadehAlice ZhuAinsleigh HillStacy HungScott BrownArtem BabaianXuehai WangRobert A. HoltChristian SteidlAly KarsanR. Keith HumphriesConnie J. EavesMartin HirstAndrew P. WengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Manabu Kusakabe Ann Chong Sun Kateryna Tyshchenko Rachel Wong Aastha Nanda Claire Shanna Samuel Gusscott Elizabeth A. Chavez Alireza Lorzadeh Alice Zhu Ainsleigh Hill Stacy Hung Scott Brown Artem Babaian Xuehai Wang Robert A. Holt Christian Steidl Aly Karsan R. Keith Humphries Connie J. Eaves Martin Hirst Andrew P. Weng Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia |
| description |
Studies with patient derived xenografts are hampered by factors such as genetic variability and sample availability. Here, the authors generate a leukemia mouse model by lentiviral transduction of normal human cord blood and show an oncogenic role of HOXB genes. |
| format |
article |
| author |
Manabu Kusakabe Ann Chong Sun Kateryna Tyshchenko Rachel Wong Aastha Nanda Claire Shanna Samuel Gusscott Elizabeth A. Chavez Alireza Lorzadeh Alice Zhu Ainsleigh Hill Stacy Hung Scott Brown Artem Babaian Xuehai Wang Robert A. Holt Christian Steidl Aly Karsan R. Keith Humphries Connie J. Eaves Martin Hirst Andrew P. Weng |
| author_facet |
Manabu Kusakabe Ann Chong Sun Kateryna Tyshchenko Rachel Wong Aastha Nanda Claire Shanna Samuel Gusscott Elizabeth A. Chavez Alireza Lorzadeh Alice Zhu Ainsleigh Hill Stacy Hung Scott Brown Artem Babaian Xuehai Wang Robert A. Holt Christian Steidl Aly Karsan R. Keith Humphries Connie J. Eaves Martin Hirst Andrew P. Weng |
| author_sort |
Manabu Kusakabe |
| title |
Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia |
| title_short |
Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia |
| title_full |
Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia |
| title_fullStr |
Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia |
| title_full_unstemmed |
Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia |
| title_sort |
synthetic modeling reveals hoxb genes are critical for the initiation and maintenance of human leukemia |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/0dc063f01a744a6691471a7f27cd84dc |
| work_keys_str_mv |
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