Effects of beta-blockers on heart failure with preserved ejection fraction: a meta-analysis.

Effects of beta-blockers on heart failure with preserved ejection fraction: a meta-analysis.

<h4>Background</h4>Effects of beta-blockers on the prognosis of the heart failure patients with preserved ejection fraction (HFpEF) remain controversial. The aim of this meta-analysis was to determine the impact of beta-blockers on mortality and hospitalization in the patients with HFpEF...

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Autores principales: Feng Liu, Yanmei Chen, Xuguang Feng, Zhonghua Teng, Ye Yuan, Jianping Bin
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/0dc0b842febc4deba4afe8e2c889aaf2
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spelling oai:doaj.org-article:0dc0b842febc4deba4afe8e2c889aaf22021-11-18T08:29:38ZEffects of beta-blockers on heart failure with preserved ejection fraction: a meta-analysis.1932-620310.1371/journal.pone.0090555https://doaj.org/article/0dc0b842febc4deba4afe8e2c889aaf22014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24599093/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Effects of beta-blockers on the prognosis of the heart failure patients with preserved ejection fraction (HFpEF) remain controversial. The aim of this meta-analysis was to determine the impact of beta-blockers on mortality and hospitalization in the patients with HFpEF.<h4>Methods</h4>A search of MEDLINE, EMBASE, and the Cochrane Library databases from 2005 to June 2013 was conducted. Clinical studies reporting outcomes of mortality and/or hospitalization for patients with HFpEF (EF ≥ 40%), being assigned to beta-blockers treatment and non-beta-blockers control group were included.<h4>Results</h4>A total of 12 clinical studies (2 randomized controlled trials and 10 observational studies) involving 21,206 HFpEF patients were included for this meta-analysis. The pooled analysis demonstrated that beta-blocker exposure was associated with a 9% reduction in relative risk for all-cause mortality in patients with HFpEF (95% CI: 0.87 - 0.95; P < 0.001). Whereas, the all-cause hospitalization, HF hospitalization and composite outcomes (mortality and hospitalization) were not affected by this treatment (P=0.26, P=0.97, and P=0.88 respectively).<h4>Conclusions</h4>The beta-blockers treatment for the patients with HFpEF was associated with a lower risk of all-cause mortality, but not with a lower risk of hospitalization. These finding were mainly obtained from observational studies, and further investigations are needed to make an assertion.Feng LiuYanmei ChenXuguang FengZhonghua TengYe YuanJianping BinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e90555 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Feng Liu
Yanmei Chen
Xuguang Feng
Zhonghua Teng
Ye Yuan
Jianping Bin
Effects of beta-blockers on heart failure with preserved ejection fraction: a meta-analysis.
description <h4>Background</h4>Effects of beta-blockers on the prognosis of the heart failure patients with preserved ejection fraction (HFpEF) remain controversial. The aim of this meta-analysis was to determine the impact of beta-blockers on mortality and hospitalization in the patients with HFpEF.<h4>Methods</h4>A search of MEDLINE, EMBASE, and the Cochrane Library databases from 2005 to June 2013 was conducted. Clinical studies reporting outcomes of mortality and/or hospitalization for patients with HFpEF (EF ≥ 40%), being assigned to beta-blockers treatment and non-beta-blockers control group were included.<h4>Results</h4>A total of 12 clinical studies (2 randomized controlled trials and 10 observational studies) involving 21,206 HFpEF patients were included for this meta-analysis. The pooled analysis demonstrated that beta-blocker exposure was associated with a 9% reduction in relative risk for all-cause mortality in patients with HFpEF (95% CI: 0.87 - 0.95; P < 0.001). Whereas, the all-cause hospitalization, HF hospitalization and composite outcomes (mortality and hospitalization) were not affected by this treatment (P=0.26, P=0.97, and P=0.88 respectively).<h4>Conclusions</h4>The beta-blockers treatment for the patients with HFpEF was associated with a lower risk of all-cause mortality, but not with a lower risk of hospitalization. These finding were mainly obtained from observational studies, and further investigations are needed to make an assertion.
format article
author Feng Liu
Yanmei Chen
Xuguang Feng
Zhonghua Teng
Ye Yuan
Jianping Bin
author_facet Feng Liu
Yanmei Chen
Xuguang Feng
Zhonghua Teng
Ye Yuan
Jianping Bin
author_sort Feng Liu
title Effects of beta-blockers on heart failure with preserved ejection fraction: a meta-analysis.
title_short Effects of beta-blockers on heart failure with preserved ejection fraction: a meta-analysis.
title_full Effects of beta-blockers on heart failure with preserved ejection fraction: a meta-analysis.
title_fullStr Effects of beta-blockers on heart failure with preserved ejection fraction: a meta-analysis.
title_full_unstemmed Effects of beta-blockers on heart failure with preserved ejection fraction: a meta-analysis.
title_sort effects of beta-blockers on heart failure with preserved ejection fraction: a meta-analysis.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/0dc0b842febc4deba4afe8e2c889aaf2
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AT yanmeichen effectsofbetablockersonheartfailurewithpreservedejectionfractionametaanalysis
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AT zhonghuateng effectsofbetablockersonheartfailurewithpreservedejectionfractionametaanalysis
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