Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease

Abstract Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternative therapies. Modulation of gut bacterial flora using probiotics is emerging as a...

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Autores principales:	Veronika Rackayová, Emmanuelle Flatt, Olivier Braissant, Jocelyn Grosse, Daniela Capobianco, Paola Mastromarino, Matthew McMillin, Sharon DeMorrow, Valérie A. McLin, Cristina Cudalbu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0dc264157648428ea4c3489515746c49
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spelling	oai:doaj.org-article:0dc264157648428ea4c3489515746c492021-12-02T10:48:13ZProbiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease10.1038/s41598-021-81871-82045-2322https://doaj.org/article/0dc264157648428ea4c3489515746c492021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81871-8https://doaj.org/toc/2045-2322Abstract Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternative therapies. Modulation of gut bacterial flora using probiotics is emerging as a therapeutic alternative. However, knowledge about how probiotics influence brain metabolite changes during HE is missing. In the present study, we combined the advantages of ultra-high field in vivo 1H MRS with behavioural tests to analyse whether a long-term treatment with a multistrain probiotic mixture (VIVOMIXX) in a rat model of type C HE had a positive effect on behaviour and neurometabolic changes. We showed that the prophylactic administration of this probiotic formulation led to an increase in gut Bifidobacteria and attenuated changes in locomotor activity and neurometabolic profile in a rat model of type C HE. Both the performance in behavioural tests and the neurometabolic profile of BDL + probiotic rats were improved compared to the BDL group at week 8 post-BDL. They displayed a significantly lesser increase in brain Gln, a milder decrease in brain mIns and a smaller decrease in neurotransmitter Glu than untreated animals. The clinical implications of these findings are potentially far-reaching given that probiotics are generally safe and well-tolerated by patients.Veronika RackayováEmmanuelle FlattOlivier BraissantJocelyn GrosseDaniela CapobiancoPaola MastromarinoMatthew McMillinSharon DeMorrowValérie A. McLinCristina CudalbuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Veronika Rackayová Emmanuelle Flatt Olivier Braissant Jocelyn Grosse Daniela Capobianco Paola Mastromarino Matthew McMillin Sharon DeMorrow Valérie A. McLin Cristina Cudalbu Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
description	Abstract Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternative therapies. Modulation of gut bacterial flora using probiotics is emerging as a therapeutic alternative. However, knowledge about how probiotics influence brain metabolite changes during HE is missing. In the present study, we combined the advantages of ultra-high field in vivo 1H MRS with behavioural tests to analyse whether a long-term treatment with a multistrain probiotic mixture (VIVOMIXX) in a rat model of type C HE had a positive effect on behaviour and neurometabolic changes. We showed that the prophylactic administration of this probiotic formulation led to an increase in gut Bifidobacteria and attenuated changes in locomotor activity and neurometabolic profile in a rat model of type C HE. Both the performance in behavioural tests and the neurometabolic profile of BDL + probiotic rats were improved compared to the BDL group at week 8 post-BDL. They displayed a significantly lesser increase in brain Gln, a milder decrease in brain mIns and a smaller decrease in neurotransmitter Glu than untreated animals. The clinical implications of these findings are potentially far-reaching given that probiotics are generally safe and well-tolerated by patients.
format	article
author	Veronika Rackayová Emmanuelle Flatt Olivier Braissant Jocelyn Grosse Daniela Capobianco Paola Mastromarino Matthew McMillin Sharon DeMorrow Valérie A. McLin Cristina Cudalbu
author_facet	Veronika Rackayová Emmanuelle Flatt Olivier Braissant Jocelyn Grosse Daniela Capobianco Paola Mastromarino Matthew McMillin Sharon DeMorrow Valérie A. McLin Cristina Cudalbu
author_sort	Veronika Rackayová
title	Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
title_short	Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
title_full	Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
title_fullStr	Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
title_full_unstemmed	Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
title_sort	probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0dc264157648428ea4c3489515746c49
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Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease

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