SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface
Antibodies targeting the spike protein of coronaviruses are potential candidates for therapeutic development. Here, Bertoglio et al. use phage display to select anti-SARS-CoV-2 spike antibodies from the human naïve universal antibody gene libraries HAL9/10 that block interaction with ACE2 receptor t...
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Nature Portfolio
2021
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oai:doaj.org-article:0dc5d5dbf361487e9f729846cf72c8082021-12-02T15:52:37ZSARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface10.1038/s41467-021-21609-22041-1723https://doaj.org/article/0dc5d5dbf361487e9f729846cf72c8082021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21609-2https://doaj.org/toc/2041-1723Antibodies targeting the spike protein of coronaviruses are potential candidates for therapeutic development. Here, Bertoglio et al. use phage display to select anti-SARS-CoV-2 spike antibodies from the human naïve universal antibody gene libraries HAL9/10 that block interaction with ACE2 receptor to inhibit infection.Federico BertoglioDoris MeierNora LangrederStephan SteinkeUlfert RandLuca SimonelliPhilip Alexander HeineRico BallmannKai-Thomas SchneiderKristian Daniel Ralph RothMaximilian RuschigPeggy RieseKathrin EschkeYeonsu KimDorina SchäckermannMattia PedottiPhilipp KuhnSusanne Zock-EmmenthalJohannes WöhrleNormann KilbTobias HerzMarlies BeckerMartina GrasshoffEsther Veronika WenzelGiulio RussoAndrea KrögerLinda BrunotteStephan LudwigViola FühnerStefan Daniel KrämerStefan DübelLuca VaraniGünter RothLuka Čičin-ŠainMaren SchubertMichael HustNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
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Science Q Federico Bertoglio Doris Meier Nora Langreder Stephan Steinke Ulfert Rand Luca Simonelli Philip Alexander Heine Rico Ballmann Kai-Thomas Schneider Kristian Daniel Ralph Roth Maximilian Ruschig Peggy Riese Kathrin Eschke Yeonsu Kim Dorina Schäckermann Mattia Pedotti Philipp Kuhn Susanne Zock-Emmenthal Johannes Wöhrle Normann Kilb Tobias Herz Marlies Becker Martina Grasshoff Esther Veronika Wenzel Giulio Russo Andrea Kröger Linda Brunotte Stephan Ludwig Viola Fühner Stefan Daniel Krämer Stefan Dübel Luca Varani Günter Roth Luka Čičin-Šain Maren Schubert Michael Hust SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface |
| description |
Antibodies targeting the spike protein of coronaviruses are potential candidates for therapeutic development. Here, Bertoglio et al. use phage display to select anti-SARS-CoV-2 spike antibodies from the human naïve universal antibody gene libraries HAL9/10 that block interaction with ACE2 receptor to inhibit infection. |
| format |
article |
| author |
Federico Bertoglio Doris Meier Nora Langreder Stephan Steinke Ulfert Rand Luca Simonelli Philip Alexander Heine Rico Ballmann Kai-Thomas Schneider Kristian Daniel Ralph Roth Maximilian Ruschig Peggy Riese Kathrin Eschke Yeonsu Kim Dorina Schäckermann Mattia Pedotti Philipp Kuhn Susanne Zock-Emmenthal Johannes Wöhrle Normann Kilb Tobias Herz Marlies Becker Martina Grasshoff Esther Veronika Wenzel Giulio Russo Andrea Kröger Linda Brunotte Stephan Ludwig Viola Fühner Stefan Daniel Krämer Stefan Dübel Luca Varani Günter Roth Luka Čičin-Šain Maren Schubert Michael Hust |
| author_facet |
Federico Bertoglio Doris Meier Nora Langreder Stephan Steinke Ulfert Rand Luca Simonelli Philip Alexander Heine Rico Ballmann Kai-Thomas Schneider Kristian Daniel Ralph Roth Maximilian Ruschig Peggy Riese Kathrin Eschke Yeonsu Kim Dorina Schäckermann Mattia Pedotti Philipp Kuhn Susanne Zock-Emmenthal Johannes Wöhrle Normann Kilb Tobias Herz Marlies Becker Martina Grasshoff Esther Veronika Wenzel Giulio Russo Andrea Kröger Linda Brunotte Stephan Ludwig Viola Fühner Stefan Daniel Krämer Stefan Dübel Luca Varani Günter Roth Luka Čičin-Šain Maren Schubert Michael Hust |
| author_sort |
Federico Bertoglio |
| title |
SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface |
| title_short |
SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface |
| title_full |
SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface |
| title_fullStr |
SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface |
| title_full_unstemmed |
SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface |
| title_sort |
sars-cov-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at rbd-ace2 interface |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/0dc5d5dbf361487e9f729846cf72c808 |
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