Parallel selection on TRPV6 in human populations.
We identified and examined a candidate gene for local directional selection in Europeans, TRPV6, and conclude that selection has acted on standing genetic variation at this locus, creating parallel soft sweep events in humans. A novel modification of the extended haplotype homozygosity (EHH) test wa...
Guardado en:
Autores principales: | David A Hughes, Kun Tang, Rainer Strotmann, Torsten Schöneberg, Jean Prenen, Bernd Nilius, Mark Stoneking |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2008
|
Materias: | |
Acceso en línea: | https://doaj.org/article/0dc6fe3f8dee46dca95fdd82ea1802e6 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Positive selection in East Asians for an EDAR allele that enhances NF-kappaB activation.
por: Jarosław Bryk, et al.
Publicado: (2008) -
Genetic variation and recent positive selection in worldwide human populations: evidence from nearly 1 million SNPs.
por: David López Herráez, et al.
Publicado: (2009) -
Conformational ensemble of the human TRPV3 ion channel
por: Lejla Zubcevic, et al.
Publicado: (2018) -
Swapping of transmembrane domains in the epithelial calcium channel TRPV6
por: Appu K. Singh, et al.
Publicado: (2017) -
Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole
por: Arthur Neuberger, et al.
Publicado: (2021)