Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance

The transmembrane P-glycoprotein (P-gp) pumps are known to promote drug resistance by enhancing drug efflux. Here, the authors deliver P-gp inhibitor and a chemotherapeutic agent using tumor blood vessel-targeting nanoparticle, to overcome drug resistance.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hai Wang, Yutong Liang, Yue Yin, Jie Zhang, Wen Su, Alisa M. White, Bin Jiang, Jiangsheng Xu, Yuntian Zhang, Samantha Stewart, Xiongbin Lu, Xiaoming He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0dcc96fe3e8f47d092bab3e71efd82f3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0dcc96fe3e8f47d092bab3e71efd82f3
record_format	dspace
spelling	oai:doaj.org-article:0dcc96fe3e8f47d092bab3e71efd82f32021-12-02T15:22:48ZCarbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance10.1038/s41467-020-20588-02041-1723https://doaj.org/article/0dcc96fe3e8f47d092bab3e71efd82f32021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20588-0https://doaj.org/toc/2041-1723The transmembrane P-glycoprotein (P-gp) pumps are known to promote drug resistance by enhancing drug efflux. Here, the authors deliver P-gp inhibitor and a chemotherapeutic agent using tumor blood vessel-targeting nanoparticle, to overcome drug resistance.Hai WangYutong LiangYue YinJie ZhangWen SuAlisa M. WhiteBin JiangJiangsheng XuYuntian ZhangSamantha StewartXiongbin LuXiaoming HeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hai Wang Yutong Liang Yue Yin Jie Zhang Wen Su Alisa M. White Bin Jiang Jiangsheng Xu Yuntian Zhang Samantha Stewart Xiongbin Lu Xiaoming He Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance
description	The transmembrane P-glycoprotein (P-gp) pumps are known to promote drug resistance by enhancing drug efflux. Here, the authors deliver P-gp inhibitor and a chemotherapeutic agent using tumor blood vessel-targeting nanoparticle, to overcome drug resistance.
format	article
author	Hai Wang Yutong Liang Yue Yin Jie Zhang Wen Su Alisa M. White Bin Jiang Jiangsheng Xu Yuntian Zhang Samantha Stewart Xiongbin Lu Xiaoming He
author_facet	Hai Wang Yutong Liang Yue Yin Jie Zhang Wen Su Alisa M. White Bin Jiang Jiangsheng Xu Yuntian Zhang Samantha Stewart Xiongbin Lu Xiaoming He
author_sort	Hai Wang
title	Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance
title_short	Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance
title_full	Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance
title_fullStr	Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance
title_full_unstemmed	Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance
title_sort	carbon nano-onion-mediated dual targeting of p-selectin and p-glycoprotein to overcome cancer drug resistance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0dcc96fe3e8f47d092bab3e71efd82f3
work_keys_str_mv	AT haiwang carbonnanoonionmediateddualtargetingofpselectinandpglycoproteintoovercomecancerdrugresistance AT yutongliang carbonnanoonionmediateddualtargetingofpselectinandpglycoproteintoovercomecancerdrugresistance AT yueyin carbonnanoonionmediateddualtargetingofpselectinandpglycoproteintoovercomecancerdrugresistance AT jiezhang carbonnanoonionmediateddualtargetingofpselectinandpglycoproteintoovercomecancerdrugresistance AT wensu carbonnanoonionmediateddualtargetingofpselectinandpglycoproteintoovercomecancerdrugresistance AT alisamwhite carbonnanoonionmediateddualtargetingofpselectinandpglycoproteintoovercomecancerdrugresistance AT binjiang carbonnanoonionmediateddualtargetingofpselectinandpglycoproteintoovercomecancerdrugresistance AT jiangshengxu carbonnanoonionmediateddualtargetingofpselectinandpglycoproteintoovercomecancerdrugresistance AT yuntianzhang carbonnanoonionmediateddualtargetingofpselectinandpglycoproteintoovercomecancerdrugresistance AT samanthastewart carbonnanoonionmediateddualtargetingofpselectinandpglycoproteintoovercomecancerdrugresistance AT xiongbinlu carbonnanoonionmediateddualtargetingofpselectinandpglycoproteintoovercomecancerdrugresistance AT xiaominghe carbonnanoonionmediateddualtargetingofpselectinandpglycoproteintoovercomecancerdrugresistance
_version_	1718387367636631552

Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance

Ejemplares similares