An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm

Vascular smooth muscle cell (VSMC) dysfunction is a common feature of thoracic aortic aneurysms (TAAs). Here, Lino Cardenas and colleagues show that the formation of a HDAC9-MALAT1-BRG1 complex promotes VSMC dysfunction in TAA by epigenetically altering the expression of key components of the cytosk...

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Autores principales:	Christian L. Lino Cardenas, Chase W. Kessinger, Yisha Cheng, Carolyn MacDonald, Thomas MacGillivray, Brian Ghoshhajra, Luai Huleihel, Saifar Nuri, Ashish S. Yeri, Farouc A. Jaffer, Naftali Kaminski, Patrick Ellinor, Neal L. Weintraub, Rajeev Malhotra, Eric M. Isselbacher, Mark E. Lindsay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0dcceeceb2e54494ba608f97eb0c0490
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spelling	oai:doaj.org-article:0dcceeceb2e54494ba608f97eb0c04902021-12-02T14:39:28ZAn HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm10.1038/s41467-018-03394-72041-1723https://doaj.org/article/0dcceeceb2e54494ba608f97eb0c04902018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03394-7https://doaj.org/toc/2041-1723Vascular smooth muscle cell (VSMC) dysfunction is a common feature of thoracic aortic aneurysms (TAAs). Here, Lino Cardenas and colleagues show that the formation of a HDAC9-MALAT1-BRG1 complex promotes VSMC dysfunction in TAA by epigenetically altering the expression of key components of the cytoskeleton in VSMCs.Christian L. Lino CardenasChase W. KessingerYisha ChengCarolyn MacDonaldThomas MacGillivrayBrian GhoshhajraLuai HuleihelSaifar NuriAshish S. YeriFarouc A. JafferNaftali KaminskiPatrick EllinorNeal L. WeintraubRajeev MalhotraEric M. IsselbacherMark E. LindsayNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christian L. Lino Cardenas Chase W. Kessinger Yisha Cheng Carolyn MacDonald Thomas MacGillivray Brian Ghoshhajra Luai Huleihel Saifar Nuri Ashish S. Yeri Farouc A. Jaffer Naftali Kaminski Patrick Ellinor Neal L. Weintraub Rajeev Malhotra Eric M. Isselbacher Mark E. Lindsay An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm
description	Vascular smooth muscle cell (VSMC) dysfunction is a common feature of thoracic aortic aneurysms (TAAs). Here, Lino Cardenas and colleagues show that the formation of a HDAC9-MALAT1-BRG1 complex promotes VSMC dysfunction in TAA by epigenetically altering the expression of key components of the cytoskeleton in VSMCs.
format	article
author	Christian L. Lino Cardenas Chase W. Kessinger Yisha Cheng Carolyn MacDonald Thomas MacGillivray Brian Ghoshhajra Luai Huleihel Saifar Nuri Ashish S. Yeri Farouc A. Jaffer Naftali Kaminski Patrick Ellinor Neal L. Weintraub Rajeev Malhotra Eric M. Isselbacher Mark E. Lindsay
author_facet	Christian L. Lino Cardenas Chase W. Kessinger Yisha Cheng Carolyn MacDonald Thomas MacGillivray Brian Ghoshhajra Luai Huleihel Saifar Nuri Ashish S. Yeri Farouc A. Jaffer Naftali Kaminski Patrick Ellinor Neal L. Weintraub Rajeev Malhotra Eric M. Isselbacher Mark E. Lindsay
author_sort	Christian L. Lino Cardenas
title	An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm
title_short	An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm
title_full	An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm
title_fullStr	An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm
title_full_unstemmed	An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm
title_sort	hdac9-malat1-brg1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0dcceeceb2e54494ba608f97eb0c0490
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An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm

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