Recent Insights Into the Prognostic and Therapeutic Applications of Lysozymes

Lysozymes are naturally occurring enzymes present in a variety of biological organisms, such as bacteria, fungi, and animal bodily secretions and tissues. It is also the main ingredient of many ethnomedicines. It is well known that lysozymes and lysozyme-like enzymes can be used as anti-bacterial ag...

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Autores principales:	Lin Jiang, Yunhe Li, Liye Wang, Jian Guo, Wei Liu, Guixian Meng, Lei Zhang, Miao Li, Lina Cong, Meiyan Sun
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	lysozyme prognosis therapy cancer hypertension viral disease Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/0dcd02db1fc2404086700e90a92bfb02
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spelling	oai:doaj.org-article:0dcd02db1fc2404086700e90a92bfb022021-12-03T07:11:40ZRecent Insights Into the Prognostic and Therapeutic Applications of Lysozymes1663-981210.3389/fphar.2021.767642https://doaj.org/article/0dcd02db1fc2404086700e90a92bfb022021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.767642/fullhttps://doaj.org/toc/1663-9812Lysozymes are naturally occurring enzymes present in a variety of biological organisms, such as bacteria, fungi, and animal bodily secretions and tissues. It is also the main ingredient of many ethnomedicines. It is well known that lysozymes and lysozyme-like enzymes can be used as anti-bacterial agents by degrading bacterial cell wall peptidoglycan that leads to cell death, and can also inhibit fungi, yeasts, and viruses. In addition to its direct antimicrobial activity, lysozyme is also an important component of the innate immune system in most mammals. Increasing evidence has shown the immune-modulatory effects of lysozymes against infection and inflammation. More recently, studies have revealed the anti-cancer activities of lysozyme in multiple types of tumors, potentially through its immune-modulatory activities. In this review, we summarized the major functions and underlying mechanisms of lysozymes derived from animal and plant sources. We highlighted the therapeutic applications and recent advances of lysozymes in cancers, hypertension, and viral diseases, aiming toseeking alternative therapies for standard medical treatment bypassing side effects. We also evaluated the role of lysozyme as a promising cancer marker for prognosis to indicate the outcomes recurrence for patients.Lin JiangYunhe LiLiye WangJian GuoWei LiuGuixian MengLei ZhangMiao LiLina CongMeiyan SunFrontiers Media S.A.articlelysozymeprognosistherapycancerhypertensionviral diseaseTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lysozyme prognosis therapy cancer hypertension viral disease Therapeutics. Pharmacology RM1-950
spellingShingle	lysozyme prognosis therapy cancer hypertension viral disease Therapeutics. Pharmacology RM1-950 Lin Jiang Yunhe Li Liye Wang Jian Guo Wei Liu Guixian Meng Lei Zhang Miao Li Lina Cong Meiyan Sun Recent Insights Into the Prognostic and Therapeutic Applications of Lysozymes
description	Lysozymes are naturally occurring enzymes present in a variety of biological organisms, such as bacteria, fungi, and animal bodily secretions and tissues. It is also the main ingredient of many ethnomedicines. It is well known that lysozymes and lysozyme-like enzymes can be used as anti-bacterial agents by degrading bacterial cell wall peptidoglycan that leads to cell death, and can also inhibit fungi, yeasts, and viruses. In addition to its direct antimicrobial activity, lysozyme is also an important component of the innate immune system in most mammals. Increasing evidence has shown the immune-modulatory effects of lysozymes against infection and inflammation. More recently, studies have revealed the anti-cancer activities of lysozyme in multiple types of tumors, potentially through its immune-modulatory activities. In this review, we summarized the major functions and underlying mechanisms of lysozymes derived from animal and plant sources. We highlighted the therapeutic applications and recent advances of lysozymes in cancers, hypertension, and viral diseases, aiming toseeking alternative therapies for standard medical treatment bypassing side effects. We also evaluated the role of lysozyme as a promising cancer marker for prognosis to indicate the outcomes recurrence for patients.
format	article
author	Lin Jiang Yunhe Li Liye Wang Jian Guo Wei Liu Guixian Meng Lei Zhang Miao Li Lina Cong Meiyan Sun
author_facet	Lin Jiang Yunhe Li Liye Wang Jian Guo Wei Liu Guixian Meng Lei Zhang Miao Li Lina Cong Meiyan Sun
author_sort	Lin Jiang
title	Recent Insights Into the Prognostic and Therapeutic Applications of Lysozymes
title_short	Recent Insights Into the Prognostic and Therapeutic Applications of Lysozymes
title_full	Recent Insights Into the Prognostic and Therapeutic Applications of Lysozymes
title_fullStr	Recent Insights Into the Prognostic and Therapeutic Applications of Lysozymes
title_full_unstemmed	Recent Insights Into the Prognostic and Therapeutic Applications of Lysozymes
title_sort	recent insights into the prognostic and therapeutic applications of lysozymes
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0dcd02db1fc2404086700e90a92bfb02
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Recent Insights Into the Prognostic and Therapeutic Applications of Lysozymes

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