Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study.

<h4>Background & aim</h4>Screening for genital infection (GI) such as bacterial vaginosis (BV) and yeast infection, for sexually transmitted infection (STI), and for asymptomatic carriage of group B streptococcus (GBS) in pregnant women are common reason for medical appointments. The...

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Autores principales:	Claire Camus, Guillaume Penaranda, Hacène Khiri, Sabine Camiade, Lucie Molet, Melissa Lebsir, Anne Plauzolles, Laurent Chiche, Bernard Blanc, Edwin Quarello, Philippe Halfon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0dd5d5e2bca24524ab8c8c12058f06ec
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spelling	oai:doaj.org-article:0dd5d5e2bca24524ab8c8c12058f06ec2021-12-02T20:12:44ZAcceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study.1932-620310.1371/journal.pone.0260021https://doaj.org/article/0dd5d5e2bca24524ab8c8c12058f06ec2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260021https://doaj.org/toc/1932-6203<h4>Background & aim</h4>Screening for genital infection (GI) such as bacterial vaginosis (BV) and yeast infection, for sexually transmitted infection (STI), and for asymptomatic carriage of group B streptococcus (GBS) in pregnant women are common reason for medical appointments. The diagnosis and control of GIs, STIs, and GBS are major issues, for fertility and overall well-being of affected women. Conventional testing is performed using vaginal/cervical classical sampling (VCS); this procedure requires pelvic examination performed by health care professionals which raises concerns among women. Vaginal-self-sampling (VSS), as an alternative to VCS, might capture more women. The aim was first to show non-inferiority of VSS compared with VCS to screen for GIs, STIs, and GBS; second to determine the feasibility of VSS.<h4>Methods</h4>VSS and VCS from 1027 women were collected by health care professionals and simultaneously carried out on each patient. GIs, STIs, and GBS were systematically screened in both paired VSS and VCS samples. Non-inferiority of VSS compared with VCS was assessed using z statistic for binomial proportions.<h4>Results</h4>Prevalence of GIs were 39.7% using VSS and 38.1% using VCS (p = 0.0016). Prevalence of STIs was 8.5% (VSS) vs 8.1% (VCS) (p = 0.0087). Prevalence of GBS was 13.4% (VSS) and 11.5% (VCS) (p = 0.0001). Most participants (84%) recommended the use of VSS.<h4>Conclusions</h4>This study shows that VSS was not inferior to VCS for the detection of GIs, STIs, and GBS. This study provides evidence that VSS can be used as a universal specimen for detection of lower genital tract infections in women.<h4>Study identification number</h4>ID-RCB 2014-A01250-4.Claire CamusGuillaume PenarandaHacène KhiriSabine CamiadeLucie MoletMelissa LebsirAnne PlauzollesLaurent ChicheBernard BlancEdwin QuarelloPhilippe HalfonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claire Camus Guillaume Penaranda Hacène Khiri Sabine Camiade Lucie Molet Melissa Lebsir Anne Plauzolles Laurent Chiche Bernard Blanc Edwin Quarello Philippe Halfon Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study.
description	<h4>Background & aim</h4>Screening for genital infection (GI) such as bacterial vaginosis (BV) and yeast infection, for sexually transmitted infection (STI), and for asymptomatic carriage of group B streptococcus (GBS) in pregnant women are common reason for medical appointments. The diagnosis and control of GIs, STIs, and GBS are major issues, for fertility and overall well-being of affected women. Conventional testing is performed using vaginal/cervical classical sampling (VCS); this procedure requires pelvic examination performed by health care professionals which raises concerns among women. Vaginal-self-sampling (VSS), as an alternative to VCS, might capture more women. The aim was first to show non-inferiority of VSS compared with VCS to screen for GIs, STIs, and GBS; second to determine the feasibility of VSS.<h4>Methods</h4>VSS and VCS from 1027 women were collected by health care professionals and simultaneously carried out on each patient. GIs, STIs, and GBS were systematically screened in both paired VSS and VCS samples. Non-inferiority of VSS compared with VCS was assessed using z statistic for binomial proportions.<h4>Results</h4>Prevalence of GIs were 39.7% using VSS and 38.1% using VCS (p = 0.0016). Prevalence of STIs was 8.5% (VSS) vs 8.1% (VCS) (p = 0.0087). Prevalence of GBS was 13.4% (VSS) and 11.5% (VCS) (p = 0.0001). Most participants (84%) recommended the use of VSS.<h4>Conclusions</h4>This study shows that VSS was not inferior to VCS for the detection of GIs, STIs, and GBS. This study provides evidence that VSS can be used as a universal specimen for detection of lower genital tract infections in women.<h4>Study identification number</h4>ID-RCB 2014-A01250-4.
format	article
author	Claire Camus Guillaume Penaranda Hacène Khiri Sabine Camiade Lucie Molet Melissa Lebsir Anne Plauzolles Laurent Chiche Bernard Blanc Edwin Quarello Philippe Halfon
author_facet	Claire Camus Guillaume Penaranda Hacène Khiri Sabine Camiade Lucie Molet Melissa Lebsir Anne Plauzolles Laurent Chiche Bernard Blanc Edwin Quarello Philippe Halfon
author_sort	Claire Camus
title	Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study.
title_short	Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study.
title_full	Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study.
title_fullStr	Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study.
title_full_unstemmed	Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study.
title_sort	acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: a cross-sectional study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0dd5d5e2bca24524ab8c8c12058f06ec
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Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study.

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