Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing

Membranous extracellular matrix (ECM)-based scaffolds are one of the most promising biomaterials for skin wound healing, some of which, such as acellular dermal matrix, small intestinal submucosa, and amniotic membrane, have been clinically applied to treat chronic wounds with acceptable outcomes. N...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lin-Cui Da, Yi-Zhou Huang, Hui-Qi Xie, Bei-Hong Zheng, Yong-Can Huang, Sheng-Rong Du
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chronic wounds extracellular matrix membranous scaffolds skin substitutes wound healing Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/0dd60178190043a9b1f6260905cfd064
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0dd60178190043a9b1f6260905cfd064
record_format	dspace
spelling	oai:doaj.org-article:0dd60178190043a9b1f6260905cfd0642021-11-25T18:40:45ZMembranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing10.3390/pharmaceutics131117961999-4923https://doaj.org/article/0dd60178190043a9b1f6260905cfd0642021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1796https://doaj.org/toc/1999-4923Membranous extracellular matrix (ECM)-based scaffolds are one of the most promising biomaterials for skin wound healing, some of which, such as acellular dermal matrix, small intestinal submucosa, and amniotic membrane, have been clinically applied to treat chronic wounds with acceptable outcomes. Nevertheless, the wide clinical applications are always hindered by the poor mechanical properties, the uncontrollable degradation, and other factors after implantation. To highlight the feasible strategies to overcome the limitations, in this review, we first outline the current clinical use of traditional membranous ECM scaffolds for skin wound healing and briefly introduce the possible repair mechanisms; then, we discuss their potential limitations and further summarize recent advances in the scaffold modification and fabrication technologies that have been applied to engineer new ECM-based membranes. With the development of scaffold modification approaches, nanotechnology and material manufacturing techniques, various types of advanced ECM-based membranes have been reported in the literature. Importantly, they possess much better properties for skin wound healing, and would become promising candidates for future clinical translation.Lin-Cui DaYi-Zhou HuangHui-Qi XieBei-Hong ZhengYong-Can HuangSheng-Rong DuMDPI AGarticlechronic woundsextracellular matrixmembranous scaffoldsskin substituteswound healingPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1796, p 1796 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic wounds extracellular matrix membranous scaffolds skin substitutes wound healing Pharmacy and materia medica RS1-441
spellingShingle	chronic wounds extracellular matrix membranous scaffolds skin substitutes wound healing Pharmacy and materia medica RS1-441 Lin-Cui Da Yi-Zhou Huang Hui-Qi Xie Bei-Hong Zheng Yong-Can Huang Sheng-Rong Du Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing
description	Membranous extracellular matrix (ECM)-based scaffolds are one of the most promising biomaterials for skin wound healing, some of which, such as acellular dermal matrix, small intestinal submucosa, and amniotic membrane, have been clinically applied to treat chronic wounds with acceptable outcomes. Nevertheless, the wide clinical applications are always hindered by the poor mechanical properties, the uncontrollable degradation, and other factors after implantation. To highlight the feasible strategies to overcome the limitations, in this review, we first outline the current clinical use of traditional membranous ECM scaffolds for skin wound healing and briefly introduce the possible repair mechanisms; then, we discuss their potential limitations and further summarize recent advances in the scaffold modification and fabrication technologies that have been applied to engineer new ECM-based membranes. With the development of scaffold modification approaches, nanotechnology and material manufacturing techniques, various types of advanced ECM-based membranes have been reported in the literature. Importantly, they possess much better properties for skin wound healing, and would become promising candidates for future clinical translation.
format	article
author	Lin-Cui Da Yi-Zhou Huang Hui-Qi Xie Bei-Hong Zheng Yong-Can Huang Sheng-Rong Du
author_facet	Lin-Cui Da Yi-Zhou Huang Hui-Qi Xie Bei-Hong Zheng Yong-Can Huang Sheng-Rong Du
author_sort	Lin-Cui Da
title	Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing
title_short	Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing
title_full	Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing
title_fullStr	Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing
title_full_unstemmed	Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing
title_sort	membranous extracellular matrix-based scaffolds for skin wound healing
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0dd60178190043a9b1f6260905cfd064
work_keys_str_mv	AT lincuida membranousextracellularmatrixbasedscaffoldsforskinwoundhealing AT yizhouhuang membranousextracellularmatrixbasedscaffoldsforskinwoundhealing AT huiqixie membranousextracellularmatrixbasedscaffoldsforskinwoundhealing AT beihongzheng membranousextracellularmatrixbasedscaffoldsforskinwoundhealing AT yongcanhuang membranousextracellularmatrixbasedscaffoldsforskinwoundhealing AT shengrongdu membranousextracellularmatrixbasedscaffoldsforskinwoundhealing
_version_	1718410815725371392

Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing

Ejemplares similares