African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa

African swine fever (ASF) is a highly infectious and fatal haemorrhagic disease of pigs that is caused by a complex DNA virus of the genus <i>Asfivirus</i> and <i>Asfarviridae</i> African suids family. The disease is among the most devastating pig diseases worldwide including...

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Autores principales:	Emma P. Njau, Eunice M. Machuka, Sarah Cleaveland, Gabriel M. Shirima, Lughano J. Kusiluka, Edward A. Okoth, Roger Pelle
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	arbovirus African swine fever virus swine pigs Africa Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/0dd82b6218d74daba5e956f7ba8b28a4
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spelling	oai:doaj.org-article:0dd82b6218d74daba5e956f7ba8b28a42021-11-25T19:14:10ZAfrican Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa10.3390/v131122851999-4915https://doaj.org/article/0dd82b6218d74daba5e956f7ba8b28a42021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2285https://doaj.org/toc/1999-4915African swine fever (ASF) is a highly infectious and fatal haemorrhagic disease of pigs that is caused by a complex DNA virus of the genus <i>Asfivirus</i> and <i>Asfarviridae</i> African suids family. The disease is among the most devastating pig diseases worldwide including Africa. Although the disease was first reported in the 19th century, it has continued to spread in Africa and other parts of the world. Globally, the rising demand for pork and concomitant increase in transboundary movements of pigs and pork products is likely to increase the risk of transmission and spread of ASF and pose a major challenge to the pig industry. Different genotypes of the ASF virus (ASFV) with varying virulence have been associated with different outbreaks in several countries in sub-Saharan Africa (SSA) and worldwide, and understanding genotype circulation will be important for ASF prevention and control strategies. ASFV genotypes unique to Africa have also been reported in SSA. This review briefly recounts the biology, genomics and genotyping of ASFV and provides an account of the different genotypes circulating in SSA. The review also highlights prevention, control and progress on vaccine development and identifies gaps in knowledge of ASFV genotype circulation in SSA that need to be addressed.Emma P. NjauEunice M. MachukaSarah CleavelandGabriel M. ShirimaLughano J. KusilukaEdward A. OkothRoger PelleMDPI AGarticlearbovirusAfrican swine fevervirusswinepigsAfricaMicrobiologyQR1-502ENViruses, Vol 13, Iss 2285, p 2285 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arbovirus African swine fever virus swine pigs Africa Microbiology QR1-502
spellingShingle	arbovirus African swine fever virus swine pigs Africa Microbiology QR1-502 Emma P. Njau Eunice M. Machuka Sarah Cleaveland Gabriel M. Shirima Lughano J. Kusiluka Edward A. Okoth Roger Pelle African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa
description	African swine fever (ASF) is a highly infectious and fatal haemorrhagic disease of pigs that is caused by a complex DNA virus of the genus <i>Asfivirus</i> and <i>Asfarviridae</i> African suids family. The disease is among the most devastating pig diseases worldwide including Africa. Although the disease was first reported in the 19th century, it has continued to spread in Africa and other parts of the world. Globally, the rising demand for pork and concomitant increase in transboundary movements of pigs and pork products is likely to increase the risk of transmission and spread of ASF and pose a major challenge to the pig industry. Different genotypes of the ASF virus (ASFV) with varying virulence have been associated with different outbreaks in several countries in sub-Saharan Africa (SSA) and worldwide, and understanding genotype circulation will be important for ASF prevention and control strategies. ASFV genotypes unique to Africa have also been reported in SSA. This review briefly recounts the biology, genomics and genotyping of ASFV and provides an account of the different genotypes circulating in SSA. The review also highlights prevention, control and progress on vaccine development and identifies gaps in knowledge of ASFV genotype circulation in SSA that need to be addressed.
format	article
author	Emma P. Njau Eunice M. Machuka Sarah Cleaveland Gabriel M. Shirima Lughano J. Kusiluka Edward A. Okoth Roger Pelle
author_facet	Emma P. Njau Eunice M. Machuka Sarah Cleaveland Gabriel M. Shirima Lughano J. Kusiluka Edward A. Okoth Roger Pelle
author_sort	Emma P. Njau
title	African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa
title_short	African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa
title_full	African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa
title_fullStr	African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa
title_full_unstemmed	African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa
title_sort	african swine fever virus (asfv): biology, genomics and genotypes circulating in sub-saharan africa
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0dd82b6218d74daba5e956f7ba8b28a4
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African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa

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