Absence of relevant QT interval prolongation in not critically ill COVID-19 patients

Abstract SARS-CoV-2 is a rapidly evolving pandemic causing great morbimortality. Medical therapy with hydroxicloroquine, azitromycin and protease inhibitors is being empirically used, with reported data of QTc interval prolongation. Our aim is to assess QT interval behaviour in a not critically ill...

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Autores principales:	Juan Jiménez-Jáimez, Rosa Macías-Ruiz, Francisco Bermúdez-Jiménez, Ricardo Rubini-Costa, Jessica Ramírez-Taboada, Paula Isabel García Flores, Laura Gallo-Padilla, Juan Diego Mediavilla García, Concepción Morales García, Sara Moreno Suárez, Celia Fignani Molina, Miguel Álvarez López, Luis Tercedor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0ddaaea59a564eee8cd88c0cb2f77917
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spelling	oai:doaj.org-article:0ddaaea59a564eee8cd88c0cb2f779172021-12-02T15:11:51ZAbsence of relevant QT interval prolongation in not critically ill COVID-19 patients10.1038/s41598-020-78360-92045-2322https://doaj.org/article/0ddaaea59a564eee8cd88c0cb2f779172020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78360-9https://doaj.org/toc/2045-2322Abstract SARS-CoV-2 is a rapidly evolving pandemic causing great morbimortality. Medical therapy with hydroxicloroquine, azitromycin and protease inhibitors is being empirically used, with reported data of QTc interval prolongation. Our aim is to assess QT interval behaviour in a not critically ill and not monitored cohort of patients. We evaluated admitted and ambulatory patients with COVID-19 patients with 12 lead electrocardiogram at 48 h after treatment initiation. Other clinical and analytical variables were collected. Statistical analysis was performed to assess the magnitude of the QT interval prolongation under treatment and to identify clinical, analytical and electrocardiographic risk markers of QT prolongation independent predictors. We included 219 patients (mean age of 63.6 ± 17.4 years, 48.9% were women and 16.4% were outpatients. The median baseline QTc was 416 ms (IQR 404–433), and after treatment QTc was prolonged to 423 ms (405–438) (P < 0.001), with an average increase of 1.8%. Most of the patients presented a normal QTc under treatment, with only 31 cases (14.1%) showing a QTc interval > 460 ms, and just one case with QTc > 500 ms. Advanced age, longer QTc basal at the basal ECG and lower potassium levels were independent predictors of QTc interval prolongation. Ambulatory and not critically ill patients with COVID-19 treated with hydroxychloroquine, azithromycin and/or antiretrovirals develop a significant, but not relevant, QT interval prolongation.Juan Jiménez-JáimezRosa Macías-RuizFrancisco Bermúdez-JiménezRicardo Rubini-CostaJessica Ramírez-TaboadaPaula Isabel García FloresLaura Gallo-PadillaJuan Diego Mediavilla GarcíaConcepción Morales GarcíaSara Moreno SuárezCelia Fignani MolinaMiguel Álvarez LópezLuis TercedorNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan Jiménez-Jáimez Rosa Macías-Ruiz Francisco Bermúdez-Jiménez Ricardo Rubini-Costa Jessica Ramírez-Taboada Paula Isabel García Flores Laura Gallo-Padilla Juan Diego Mediavilla García Concepción Morales García Sara Moreno Suárez Celia Fignani Molina Miguel Álvarez López Luis Tercedor Absence of relevant QT interval prolongation in not critically ill COVID-19 patients
description	Abstract SARS-CoV-2 is a rapidly evolving pandemic causing great morbimortality. Medical therapy with hydroxicloroquine, azitromycin and protease inhibitors is being empirically used, with reported data of QTc interval prolongation. Our aim is to assess QT interval behaviour in a not critically ill and not monitored cohort of patients. We evaluated admitted and ambulatory patients with COVID-19 patients with 12 lead electrocardiogram at 48 h after treatment initiation. Other clinical and analytical variables were collected. Statistical analysis was performed to assess the magnitude of the QT interval prolongation under treatment and to identify clinical, analytical and electrocardiographic risk markers of QT prolongation independent predictors. We included 219 patients (mean age of 63.6 ± 17.4 years, 48.9% were women and 16.4% were outpatients. The median baseline QTc was 416 ms (IQR 404–433), and after treatment QTc was prolonged to 423 ms (405–438) (P < 0.001), with an average increase of 1.8%. Most of the patients presented a normal QTc under treatment, with only 31 cases (14.1%) showing a QTc interval > 460 ms, and just one case with QTc > 500 ms. Advanced age, longer QTc basal at the basal ECG and lower potassium levels were independent predictors of QTc interval prolongation. Ambulatory and not critically ill patients with COVID-19 treated with hydroxychloroquine, azithromycin and/or antiretrovirals develop a significant, but not relevant, QT interval prolongation.
format	article
author	Juan Jiménez-Jáimez Rosa Macías-Ruiz Francisco Bermúdez-Jiménez Ricardo Rubini-Costa Jessica Ramírez-Taboada Paula Isabel García Flores Laura Gallo-Padilla Juan Diego Mediavilla García Concepción Morales García Sara Moreno Suárez Celia Fignani Molina Miguel Álvarez López Luis Tercedor
author_facet	Juan Jiménez-Jáimez Rosa Macías-Ruiz Francisco Bermúdez-Jiménez Ricardo Rubini-Costa Jessica Ramírez-Taboada Paula Isabel García Flores Laura Gallo-Padilla Juan Diego Mediavilla García Concepción Morales García Sara Moreno Suárez Celia Fignani Molina Miguel Álvarez López Luis Tercedor
author_sort	Juan Jiménez-Jáimez
title	Absence of relevant QT interval prolongation in not critically ill COVID-19 patients
title_short	Absence of relevant QT interval prolongation in not critically ill COVID-19 patients
title_full	Absence of relevant QT interval prolongation in not critically ill COVID-19 patients
title_fullStr	Absence of relevant QT interval prolongation in not critically ill COVID-19 patients
title_full_unstemmed	Absence of relevant QT interval prolongation in not critically ill COVID-19 patients
title_sort	absence of relevant qt interval prolongation in not critically ill covid-19 patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0ddaaea59a564eee8cd88c0cb2f77917
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Absence of relevant QT interval prolongation in not critically ill COVID-19 patients

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