Nonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid

A world preceding the prebiotic RNA-world may have been based on xeno nucleic acids (XNAs), but their replication likely did not require enzymes. Here, the authors demonstrate template-directed non-enzymatic synthesis of an XNA, acyclic l-threoninol nucleic acid, via chemical ligation mediated by N-...

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Autores principales:	Keiji Murayama, Hikari Okita, Takumi Kuriki, Hiroyuki Asanuma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0de48c92b05449cea83cfb17dc21c6fd
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spelling	oai:doaj.org-article:0de48c92b05449cea83cfb17dc21c6fd2021-12-02T14:33:40ZNonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid10.1038/s41467-021-21128-02041-1723https://doaj.org/article/0de48c92b05449cea83cfb17dc21c6fd2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21128-0https://doaj.org/toc/2041-1723A world preceding the prebiotic RNA-world may have been based on xeno nucleic acids (XNAs), but their replication likely did not require enzymes. Here, the authors demonstrate template-directed non-enzymatic synthesis of an XNA, acyclic l-threoninol nucleic acid, via chemical ligation mediated by N-cyanoimidazole, and achieve a pseudo-primer extension of this XNA with all four nucleobases.Keiji MurayamaHikari OkitaTakumi KurikiHiroyuki AsanumaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Keiji Murayama Hikari Okita Takumi Kuriki Hiroyuki Asanuma Nonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid
description	A world preceding the prebiotic RNA-world may have been based on xeno nucleic acids (XNAs), but their replication likely did not require enzymes. Here, the authors demonstrate template-directed non-enzymatic synthesis of an XNA, acyclic l-threoninol nucleic acid, via chemical ligation mediated by N-cyanoimidazole, and achieve a pseudo-primer extension of this XNA with all four nucleobases.
format	article
author	Keiji Murayama Hikari Okita Takumi Kuriki Hiroyuki Asanuma
author_facet	Keiji Murayama Hikari Okita Takumi Kuriki Hiroyuki Asanuma
author_sort	Keiji Murayama
title	Nonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid
title_short	Nonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid
title_full	Nonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid
title_fullStr	Nonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid
title_full_unstemmed	Nonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid
title_sort	nonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0de48c92b05449cea83cfb17dc21c6fd
work_keys_str_mv	AT keijimurayama nonenzymaticpolymeraseliketemplatedirectedsynthesisofacycliclthreoninolnucleicacid AT hikariokita nonenzymaticpolymeraseliketemplatedirectedsynthesisofacycliclthreoninolnucleicacid AT takumikuriki nonenzymaticpolymeraseliketemplatedirectedsynthesisofacycliclthreoninolnucleicacid AT hiroyukiasanuma nonenzymaticpolymeraseliketemplatedirectedsynthesisofacycliclthreoninolnucleicacid
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Nonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid

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