Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation

Abstract To characterize laser speckle flowgraphy (LSFG) pulse waveform parameters for ocular circulation evaluation, a multicenter, prospective, cross-sectional study was conducted in 111 eyes of 86 healthy Japanese individuals. Optic nerve head (ONH) tissue-area, vessel-area mean blur rate (MT and...

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Autores principales:	Nobuko Enomoto, Ayako Anraku, Goji Tomita, Aiko Iwase, Takashi Sato, Nobuyuki Shoji, Tomoaki Shiba, Toru Nakazawa, Kazuhisa Sugiyama, Koji Nitta, Makoto Araie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0de60f9cb2d04a4091b46b2b7ed93a59
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spelling	oai:doaj.org-article:0de60f9cb2d04a4091b46b2b7ed93a592021-12-02T13:24:14ZCharacterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation10.1038/s41598-021-86280-52045-2322https://doaj.org/article/0de60f9cb2d04a4091b46b2b7ed93a592021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86280-5https://doaj.org/toc/2045-2322Abstract To characterize laser speckle flowgraphy (LSFG) pulse waveform parameters for ocular circulation evaluation, a multicenter, prospective, cross-sectional study was conducted in 111 eyes of 86 healthy Japanese individuals. Optic nerve head (ONH) tissue-area, vessel-area mean blur rate (MT and MV, respectively), and MT and MV pulse waveform parameters were obtained using LSFG and ONH structural parameters using planimetry. Multivariate linear mixed-effects modeled regression analysis identified factors contributing to MT- or MV-waveforms using age, gender, smoking history, body mass index, systolic and diastolic blood pressure, heart rate, intraocular pressure, axial length, disc, rim, and β-peripapillary atrophy areas, MT or MV, central retinal artery, and vein equivalents (CRAE and CRVE) as explanatory variables. MT- and MV-waveforms significantly correlated with one or more systemic factors, consistent with previous studies. Following confounding factor adjustment, MT-Skew significantly negatively correlated with β-PPA area (P = 0.026); MT- and MV-flow acceleration index positively correlated with CRAE, MT, and MV (P = 0.041–< 0.001), compatible with these parameters’ observed correlations to systemic factors. Significantly negative correlations of the blowout score and acceleration time index to CRAE partly conflicted with their correlations to systemic factors, and other waveform parameters showed little correlation to ocular factors. Thus, Skew and flow acceleration index assisted the in vivo ocular circulation characterization.Nobuko EnomotoAyako AnrakuGoji TomitaAiko IwaseTakashi SatoNobuyuki ShojiTomoaki ShibaToru NakazawaKazuhisa SugiyamaKoji NittaMakoto AraieNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nobuko Enomoto Ayako Anraku Goji Tomita Aiko Iwase Takashi Sato Nobuyuki Shoji Tomoaki Shiba Toru Nakazawa Kazuhisa Sugiyama Koji Nitta Makoto Araie Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation
description	Abstract To characterize laser speckle flowgraphy (LSFG) pulse waveform parameters for ocular circulation evaluation, a multicenter, prospective, cross-sectional study was conducted in 111 eyes of 86 healthy Japanese individuals. Optic nerve head (ONH) tissue-area, vessel-area mean blur rate (MT and MV, respectively), and MT and MV pulse waveform parameters were obtained using LSFG and ONH structural parameters using planimetry. Multivariate linear mixed-effects modeled regression analysis identified factors contributing to MT- or MV-waveforms using age, gender, smoking history, body mass index, systolic and diastolic blood pressure, heart rate, intraocular pressure, axial length, disc, rim, and β-peripapillary atrophy areas, MT or MV, central retinal artery, and vein equivalents (CRAE and CRVE) as explanatory variables. MT- and MV-waveforms significantly correlated with one or more systemic factors, consistent with previous studies. Following confounding factor adjustment, MT-Skew significantly negatively correlated with β-PPA area (P = 0.026); MT- and MV-flow acceleration index positively correlated with CRAE, MT, and MV (P = 0.041–< 0.001), compatible with these parameters’ observed correlations to systemic factors. Significantly negative correlations of the blowout score and acceleration time index to CRAE partly conflicted with their correlations to systemic factors, and other waveform parameters showed little correlation to ocular factors. Thus, Skew and flow acceleration index assisted the in vivo ocular circulation characterization.
format	article
author	Nobuko Enomoto Ayako Anraku Goji Tomita Aiko Iwase Takashi Sato Nobuyuki Shoji Tomoaki Shiba Toru Nakazawa Kazuhisa Sugiyama Koji Nitta Makoto Araie
author_facet	Nobuko Enomoto Ayako Anraku Goji Tomita Aiko Iwase Takashi Sato Nobuyuki Shoji Tomoaki Shiba Toru Nakazawa Kazuhisa Sugiyama Koji Nitta Makoto Araie
author_sort	Nobuko Enomoto
title	Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation
title_short	Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation
title_full	Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation
title_fullStr	Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation
title_full_unstemmed	Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation
title_sort	characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0de60f9cb2d04a4091b46b2b7ed93a59
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Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation

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