A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells

Jonghoon Choi,1,2 Mintai P Hwang,3 Jong-Wook Lee,3 Kwan Hyi Lee3,41Institute of Research Strategy and Development (IRSD), Seoul, Republic of Korea; 2Department of Bionano Engineering, Hanyang University, Ansan, Republic of Korea; 3Center for Biomaterials, Biomedical Research Institute, Korea Instit...

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Autores principales:	Choi J, Hwang MP, Lee JW, Lee KH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0de802ada57543e2b14b6c70e2d278f9
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spelling	oai:doaj.org-article:0de802ada57543e2b14b6c70e2d278f92021-12-02T06:33:28ZA glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells1178-2013https://doaj.org/article/0de802ada57543e2b14b6c70e2d278f92014-05-01T00:00:00Zhttp://www.dovepress.com/a-glimpse-into-the-interactions-of-cells-in-a-microenvironment-the-mod-a16700https://doaj.org/toc/1178-2013 Jonghoon Choi,1,2 Mintai P Hwang,3 Jong-Wook Lee,3 Kwan Hyi Lee3,41Institute of Research Strategy and Development (IRSD), Seoul, Republic of Korea; 2Department of Bionano Engineering, Hanyang University, Ansan, Republic of Korea; 3Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea; 4Department of Biomedical Engineering, University of Science and Technology, Seoul, Republic of KoreaAbstract: Mesenchymal stem cells (MSCs) have been thought to hold potential as a mode of therapy for immuno-related pathologies, particularly for autoimmune diseases. Despite their potential, the interaction between MSCs and T cells, key players in the pathophysiology of autoimmune diseases, is not yet well understood, thereby preventing further clinical progress. A major obstacle is the highly heterogeneous nature of MSCs in vitro. Unfortunately, bulk assays do not provide information with regard to cell–cell contributions that may play a critical role in the overall cellular response. To address these issues, we investigated the interaction between smaller subsets of MSCs and CD4 T cells in a microwell array. We demonstrate that MSCs appear capable of modulating the T cell proliferation rate in response to persistent cell–cell interactions, and we anticipate the use of our microwell array in the classification of subpopulations within MSCs, ultimately leading to specific therapeutic interventions.Keywords: mesenchymal stem cell, T cell, microwell arrayChoi JHwang MPLee JWLee KHDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Supplement 1, Pp 127-139 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Choi J Hwang MP Lee JW Lee KH A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells
description	Jonghoon Choi,1,2 Mintai P Hwang,3 Jong-Wook Lee,3 Kwan Hyi Lee3,41Institute of Research Strategy and Development (IRSD), Seoul, Republic of Korea; 2Department of Bionano Engineering, Hanyang University, Ansan, Republic of Korea; 3Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea; 4Department of Biomedical Engineering, University of Science and Technology, Seoul, Republic of KoreaAbstract: Mesenchymal stem cells (MSCs) have been thought to hold potential as a mode of therapy for immuno-related pathologies, particularly for autoimmune diseases. Despite their potential, the interaction between MSCs and T cells, key players in the pathophysiology of autoimmune diseases, is not yet well understood, thereby preventing further clinical progress. A major obstacle is the highly heterogeneous nature of MSCs in vitro. Unfortunately, bulk assays do not provide information with regard to cell–cell contributions that may play a critical role in the overall cellular response. To address these issues, we investigated the interaction between smaller subsets of MSCs and CD4 T cells in a microwell array. We demonstrate that MSCs appear capable of modulating the T cell proliferation rate in response to persistent cell–cell interactions, and we anticipate the use of our microwell array in the classification of subpopulations within MSCs, ultimately leading to specific therapeutic interventions.Keywords: mesenchymal stem cell, T cell, microwell array
format	article
author	Choi J Hwang MP Lee JW Lee KH
author_facet	Choi J Hwang MP Lee JW Lee KH
author_sort	Choi J
title	A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells
title_short	A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells
title_full	A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells
title_fullStr	A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells
title_full_unstemmed	A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells
title_sort	glimpse into the interactions of cells in a microenvironment: the modulation of t cells by mesenchymal stem cells
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/0de802ada57543e2b14b6c70e2d278f9
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A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells

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