Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history

Since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread from the early epicenter, Wuhan, to the rest of China, the virulence of SARS-CoV-2 might have evolved at different phases of the pandemic. We therefore compared the unique features among 62 coronavirus disease 2019 (COVID-19)...

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Autores principales:	Yinjie Gao, Xuemei Ma, Jingfeng Bi, Jindong Chu, Bo Liu, Chunsheng Chi, Jianguo Yan, Xiaoli Yu, Fangming Liu, Xiaohong Deng, Hongbing Zhang, Bo Jin
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	coronavirus sars-cov-2 covid-19 incubation period pandemic virulence Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/0dea6c10186f428eb2dce132e7933820
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spelling	oai:doaj.org-article:0dea6c10186f428eb2dce132e79338202021-11-17T14:21:58ZEpidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history2150-55942150-560810.1080/21505594.2020.1802870https://doaj.org/article/0dea6c10186f428eb2dce132e79338202020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1802870https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread from the early epicenter, Wuhan, to the rest of China, the virulence of SARS-CoV-2 might have evolved at different phases of the pandemic. We therefore compared the unique features among 62 coronavirus disease 2019 (COVID-19) inpatients who contracted SARS-CoV-2 in Wuhan (15 cases), exposed to the patients from Wuhan (26 cases), or acquired the disease without exposure to Wuhan patients (21 cases). Median incubation periods are 4.5 days (3–5) for Wuhan patients, 8 days (3–11) for those infected by Wuhan patients, and 12 days (7–13) for those without aforementioned experience. The disease onset dates are earliest for Wuhan patients and latest for those without exposure to Wuhan patients. Blood lymphocytes were lowest in Wuhan patients, lower in those affected by Wuhan patients, and modest reduced in remaining ones. Disease severity is worst for Wuhan patients, and modest for those without contact with Wuhan patients. Wuhan patients had longest (27 days, 18–28), those transmitted by Wuhan patients had intermediate (16 days, 8–23), and the rest of the patients had shortest (13 days, 8.5–22.5) hospital stay. Early viral exposure, older age, lymphocytopenia, and underlying conditions are risk factors which warrant aggressive intervention. Even though the virulence of SARS-CoV-2 appears decline over the course of serial transmissions, viral testing, contact tracing, social distancing, and face masking should be imposed on general public to contain viral dissemination from both symptomatic and asymptomatic patients with this highly contagious disease.Yinjie GaoXuemei MaJingfeng BiJindong ChuBo LiuChunsheng ChiJianguo YanXiaoli YuFangming LiuXiaohong DengHongbing ZhangBo JinTaylor & Francis Grouparticlecoronavirussars-cov-2covid-19incubation periodpandemicvirulenceInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 1015-1023 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	coronavirus sars-cov-2 covid-19 incubation period pandemic virulence Infectious and parasitic diseases RC109-216
spellingShingle	coronavirus sars-cov-2 covid-19 incubation period pandemic virulence Infectious and parasitic diseases RC109-216 Yinjie Gao Xuemei Ma Jingfeng Bi Jindong Chu Bo Liu Chunsheng Chi Jianguo Yan Xiaoli Yu Fangming Liu Xiaohong Deng Hongbing Zhang Bo Jin Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history
description	Since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread from the early epicenter, Wuhan, to the rest of China, the virulence of SARS-CoV-2 might have evolved at different phases of the pandemic. We therefore compared the unique features among 62 coronavirus disease 2019 (COVID-19) inpatients who contracted SARS-CoV-2 in Wuhan (15 cases), exposed to the patients from Wuhan (26 cases), or acquired the disease without exposure to Wuhan patients (21 cases). Median incubation periods are 4.5 days (3–5) for Wuhan patients, 8 days (3–11) for those infected by Wuhan patients, and 12 days (7–13) for those without aforementioned experience. The disease onset dates are earliest for Wuhan patients and latest for those without exposure to Wuhan patients. Blood lymphocytes were lowest in Wuhan patients, lower in those affected by Wuhan patients, and modest reduced in remaining ones. Disease severity is worst for Wuhan patients, and modest for those without contact with Wuhan patients. Wuhan patients had longest (27 days, 18–28), those transmitted by Wuhan patients had intermediate (16 days, 8–23), and the rest of the patients had shortest (13 days, 8.5–22.5) hospital stay. Early viral exposure, older age, lymphocytopenia, and underlying conditions are risk factors which warrant aggressive intervention. Even though the virulence of SARS-CoV-2 appears decline over the course of serial transmissions, viral testing, contact tracing, social distancing, and face masking should be imposed on general public to contain viral dissemination from both symptomatic and asymptomatic patients with this highly contagious disease.
format	article
author	Yinjie Gao Xuemei Ma Jingfeng Bi Jindong Chu Bo Liu Chunsheng Chi Jianguo Yan Xiaoli Yu Fangming Liu Xiaohong Deng Hongbing Zhang Bo Jin
author_facet	Yinjie Gao Xuemei Ma Jingfeng Bi Jindong Chu Bo Liu Chunsheng Chi Jianguo Yan Xiaoli Yu Fangming Liu Xiaohong Deng Hongbing Zhang Bo Jin
author_sort	Yinjie Gao
title	Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history
title_short	Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history
title_full	Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history
title_fullStr	Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history
title_full_unstemmed	Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history
title_sort	epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/0dea6c10186f428eb2dce132e7933820
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Epidemiological and clinical differences of coronavirus disease 2019 patients with distinct viral exposure history

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