HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS

In the present study we characterized the effect of transplantation of bone marrow and adipose tissue MSCs in the model of brain injury in rats. This study was performed on Wistar rats (males and females in equal proportions with body weight of 250—270 g; n = 50). Traumatic brain injury was produced...

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Autores principales:	E. V. Polovnikov, V. V. Stupak, A. G. Samokhin, I. A. Vasiliev, O. B. Dobryakova, E. Ya. Shevela, E. R. Chernykh
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	controlled cortical injury model neurological deficit mesenchymal stem marrow adipose cells Science Q
Acceso en línea:	https://doaj.org/article/0dea75fb9b2146e183db58a1c05ba018
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spelling	oai:doaj.org-article:0dea75fb9b2146e183db58a1c05ba0182021-11-23T06:14:20ZHUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS2541-94202587-9596https://doaj.org/article/0dea75fb9b2146e183db58a1c05ba0182012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/939https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596In the present study we characterized the effect of transplantation of bone marrow and adipose tissue MSCs in the model of brain injury in rats. This study was performed on Wistar rats (males and females in equal proportions with body weight of 250—270 g; n = 50). Traumatic brain injury was produced, by original spring-loaded, mechanism to precise dosing of impact force. Neurological disorders were assessed by Chen scale, a vertical grid test and a Morris water maze. MSC injections on day 1 were accompanied by a significant reduction in neurological deficit in compare with the control group. Adipose tissue derived MSCs were found to have a more pronounced effectiveness than MSCs obtained from bone marrow.E. V. PolovnikovV. V. StupakA. G. SamokhinI. A. VasilievO. B. DobryakovaE. Ya. ShevelaE. R. ChernykhScientific Сentre for Family Health and Human Reproduction Problemsarticlecontrolled cortical injury modelneurological deficitmesenchymal stem marrowadipose cellsScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 301-304 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	controlled cortical injury model neurological deficit mesenchymal stem marrow adipose cells Science Q
spellingShingle	controlled cortical injury model neurological deficit mesenchymal stem marrow adipose cells Science Q E. V. Polovnikov V. V. Stupak A. G. Samokhin I. A. Vasiliev O. B. Dobryakova E. Ya. Shevela E. R. Chernykh HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS
description	In the present study we characterized the effect of transplantation of bone marrow and adipose tissue MSCs in the model of brain injury in rats. This study was performed on Wistar rats (males and females in equal proportions with body weight of 250—270 g; n = 50). Traumatic brain injury was produced, by original spring-loaded, mechanism to precise dosing of impact force. Neurological disorders were assessed by Chen scale, a vertical grid test and a Morris water maze. MSC injections on day 1 were accompanied by a significant reduction in neurological deficit in compare with the control group. Adipose tissue derived MSCs were found to have a more pronounced effectiveness than MSCs obtained from bone marrow.
format	article
author	E. V. Polovnikov V. V. Stupak A. G. Samokhin I. A. Vasiliev O. B. Dobryakova E. Ya. Shevela E. R. Chernykh
author_facet	E. V. Polovnikov V. V. Stupak A. G. Samokhin I. A. Vasiliev O. B. Dobryakova E. Ya. Shevela E. R. Chernykh
author_sort	E. V. Polovnikov
title	HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS
title_short	HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS
title_full	HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS
title_fullStr	HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS
title_full_unstemmed	HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS
title_sort	human bone marrow and adipose tissue derived mesenchymal stromal cell influence on neurological deficit recovery in a model of severe traumatic brain injury in rats
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/0dea75fb9b2146e183db58a1c05ba018
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HUMAN BONE MARROW AND ADIPOSE TISSUE DERIVED MESENCHYMAL STROMAL CELL INFLUENCE ON NEUROLOGICAL DEFICIT RECOVERY IN A MODEL OF SEVERE TRAUMATIC BRAIN INJURY IN RATS

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