The limit of tolerable micromotion for implant osseointegration: a systematic review

Abstract Much research effort is being invested into the development of porous biomaterials that enhance implant osseointegration. Large micromotions at the bone-implant interface impair this osseointegration process, resulting in fibrous capsule formation and implant loosening. This systematic revi...

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Autores principales:	Nupur Kohli, Jennifer C. Stoddart, Richard J. van Arkel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0df24780b5124cc4a52b7616fc197545
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spelling	oai:doaj.org-article:0df24780b5124cc4a52b7616fc1975452021-12-02T15:49:28ZThe limit of tolerable micromotion for implant osseointegration: a systematic review10.1038/s41598-021-90142-52045-2322https://doaj.org/article/0df24780b5124cc4a52b7616fc1975452021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90142-5https://doaj.org/toc/2045-2322Abstract Much research effort is being invested into the development of porous biomaterials that enhance implant osseointegration. Large micromotions at the bone-implant interface impair this osseointegration process, resulting in fibrous capsule formation and implant loosening. This systematic review compiled all the in vivo evidence available to establish if there is a universal limit of tolerable micromotion for implant osseointegration. The protocol was registered with the International Prospective Register for Systematic Reviews (ID: CRD42020196686). Pubmed, Scopus and Web of Knowledge databases were searched for studies containing terms relating to micromotion and osseointegration. The mean value of micromotion for implants that osseointegrated was 32% of the mean value for those that did not (112 ± 176 µm versus 349 ± 231 µm, p < 0.001). However, there was a large overlap in the data ranges with no universal limit apparent. Rather, many factors were found to combine to affect the overall outcome including loading time, the type of implant and the material being used. The tables provided in this review summarise these factors and will aid investigators in identifying the most relevant micromotion values for their biomaterial and implant development research.Nupur KohliJennifer C. StoddartRichard J. van ArkelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nupur Kohli Jennifer C. Stoddart Richard J. van Arkel The limit of tolerable micromotion for implant osseointegration: a systematic review
description	Abstract Much research effort is being invested into the development of porous biomaterials that enhance implant osseointegration. Large micromotions at the bone-implant interface impair this osseointegration process, resulting in fibrous capsule formation and implant loosening. This systematic review compiled all the in vivo evidence available to establish if there is a universal limit of tolerable micromotion for implant osseointegration. The protocol was registered with the International Prospective Register for Systematic Reviews (ID: CRD42020196686). Pubmed, Scopus and Web of Knowledge databases were searched for studies containing terms relating to micromotion and osseointegration. The mean value of micromotion for implants that osseointegrated was 32% of the mean value for those that did not (112 ± 176 µm versus 349 ± 231 µm, p < 0.001). However, there was a large overlap in the data ranges with no universal limit apparent. Rather, many factors were found to combine to affect the overall outcome including loading time, the type of implant and the material being used. The tables provided in this review summarise these factors and will aid investigators in identifying the most relevant micromotion values for their biomaterial and implant development research.
format	article
author	Nupur Kohli Jennifer C. Stoddart Richard J. van Arkel
author_facet	Nupur Kohli Jennifer C. Stoddart Richard J. van Arkel
author_sort	Nupur Kohli
title	The limit of tolerable micromotion for implant osseointegration: a systematic review
title_short	The limit of tolerable micromotion for implant osseointegration: a systematic review
title_full	The limit of tolerable micromotion for implant osseointegration: a systematic review
title_fullStr	The limit of tolerable micromotion for implant osseointegration: a systematic review
title_full_unstemmed	The limit of tolerable micromotion for implant osseointegration: a systematic review
title_sort	limit of tolerable micromotion for implant osseointegration: a systematic review
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0df24780b5124cc4a52b7616fc197545
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The limit of tolerable micromotion for implant osseointegration: a systematic review

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