IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM

Abstract. One hundred and ninety-nine patients with hyperplastic processes of reproductive system were examined, and 131 (66.16%) of them were found to be infected with Chlamydia or Ureaplasma. The mean age of female patients was 42,7±1,35 years. Different infectious agents (e.g. Chlamydia trachomat...

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Autores principales:	A. A. Lukach, O. A. Minyailo, V. I. Konovalov, A. I. Olkhovikov, N. V. Kungurov, N. M. Gerasimova, N. P. Evstigneeva, Ya. B. Beykin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immunity cd3+ lymphocytes cytokines hyperplastic processes infection Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/0df5552db51c4f3faa12e176f98a45c7
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spelling	oai:doaj.org-article:0df5552db51c4f3faa12e176f98a45c72021-11-18T08:03:38ZIMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM1563-06252313-741X10.15789/1563-0625-2008-2-3-223-228https://doaj.org/article/0df5552db51c4f3faa12e176f98a45c72014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/151https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. One hundred and ninety-nine patients with hyperplastic processes of reproductive system were examined, and 131 (66.16%) of them were found to be infected with Chlamydia or Ureaplasma. The mean age of female patients was 42,7±1,35 years. Different infectious agents (e.g. Chlamydia trachomatis, Ureaplasma urealiticum, Mycoplasma hominis) were identified in cervical canal of uterine cervix and surgical specimens (biopsy samples of excised myoma, adenomyosis or endometrial hyperplasia). The infected patients were found to have decreased monocytes and neutrophils in blood counts, lower phagocytic activity of monocytes and neutrophils, and decreased bactericidal activity of leukocytes. Other findings included lower CD20+, CD8+ and rFAS CD 95 lymphocytes. Assessment of cytokine-synthesizing activity of CD3+ lymphocytes showed a decrease in both spontaneous and stimulated response (р < 0,001). A weakest spontaneous and stimulated response was found in CD3+/IL-4+ lymphocytes. Analysis of results obtained shows systemic immune disorders and impaired cytokine-synthesizing activity of CD3+ lymphocytes correlating with infection factors in the women with hyperplastic processes of reproductive system. (Med. Immunol., 2008, vol. 10, N 2-3, pp 223-228).A. A. LukachO. A. MinyailoV. I. KonovalovA. I. OlkhovikovN. V. KungurovN. M. GerasimovaN. P. EvstigneevaYa. B. BeykinSPb RAACIarticleimmunitycd3+ lymphocytescytokineshyperplastic processesinfectionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 2-3, Pp 223-228 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immunity cd3+ lymphocytes cytokines hyperplastic processes infection Immunologic diseases. Allergy RC581-607
spellingShingle	immunity cd3+ lymphocytes cytokines hyperplastic processes infection Immunologic diseases. Allergy RC581-607 A. A. Lukach O. A. Minyailo V. I. Konovalov A. I. Olkhovikov N. V. Kungurov N. M. Gerasimova N. P. Evstigneeva Ya. B. Beykin IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM
description	Abstract. One hundred and ninety-nine patients with hyperplastic processes of reproductive system were examined, and 131 (66.16%) of them were found to be infected with Chlamydia or Ureaplasma. The mean age of female patients was 42,7±1,35 years. Different infectious agents (e.g. Chlamydia trachomatis, Ureaplasma urealiticum, Mycoplasma hominis) were identified in cervical canal of uterine cervix and surgical specimens (biopsy samples of excised myoma, adenomyosis or endometrial hyperplasia). The infected patients were found to have decreased monocytes and neutrophils in blood counts, lower phagocytic activity of monocytes and neutrophils, and decreased bactericidal activity of leukocytes. Other findings included lower CD20+, CD8+ and rFAS CD 95 lymphocytes. Assessment of cytokine-synthesizing activity of CD3+ lymphocytes showed a decrease in both spontaneous and stimulated response (р < 0,001). A weakest spontaneous and stimulated response was found in CD3+/IL-4+ lymphocytes. Analysis of results obtained shows systemic immune disorders and impaired cytokine-synthesizing activity of CD3+ lymphocytes correlating with infection factors in the women with hyperplastic processes of reproductive system. (Med. Immunol., 2008, vol. 10, N 2-3, pp 223-228).
format	article
author	A. A. Lukach O. A. Minyailo V. I. Konovalov A. I. Olkhovikov N. V. Kungurov N. M. Gerasimova N. P. Evstigneeva Ya. B. Beykin
author_facet	A. A. Lukach O. A. Minyailo V. I. Konovalov A. I. Olkhovikov N. V. Kungurov N. M. Gerasimova N. P. Evstigneeva Ya. B. Beykin
author_sort	A. A. Lukach
title	IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM
title_short	IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM
title_full	IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM
title_fullStr	IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM
title_full_unstemmed	IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM
title_sort	immunity and infection in women with hyperplastic states of immune system
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/0df5552db51c4f3faa12e176f98a45c7
work_keys_str_mv	AT aalukach immunityandinfectioninwomenwithhyperplasticstatesofimmunesystem AT oaminyailo immunityandinfectioninwomenwithhyperplasticstatesofimmunesystem AT vikonovalov immunityandinfectioninwomenwithhyperplasticstatesofimmunesystem AT aiolkhovikov immunityandinfectioninwomenwithhyperplasticstatesofimmunesystem AT nvkungurov immunityandinfectioninwomenwithhyperplasticstatesofimmunesystem AT nmgerasimova immunityandinfectioninwomenwithhyperplasticstatesofimmunesystem AT npevstigneeva immunityandinfectioninwomenwithhyperplasticstatesofimmunesystem AT yabbeykin immunityandinfectioninwomenwithhyperplasticstatesofimmunesystem
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IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM

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