The Baerveldt Glaucoma Drainage Device: Efficacy, Safety, and Place in Therapy

Huub J Poelman, Roger CW Wolfs, Wishal D Ramdas Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the NetherlandsCorrespondence: Wishal D RamdasDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, ‘S Gravendijkwal 230, CE 3015, Rotterdam, The NetherlandsEmail w.ram...

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Autores principales:	Poelman HJ, Wolfs RCW, Ramdas WD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	baerveldt implant glaucoma drainage device glaucoma intraocular pressure Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/0df58b66e8db49d69099952b79789a1d
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spelling	oai:doaj.org-article:0df58b66e8db49d69099952b79789a1d2021-12-02T05:44:11ZThe Baerveldt Glaucoma Drainage Device: Efficacy, Safety, and Place in Therapy1177-5483https://doaj.org/article/0df58b66e8db49d69099952b79789a1d2020-09-01T00:00:00Zhttps://www.dovepress.com/the-baerveldt-glaucoma-drainage-device-efficacy-safety-and-place-in-th-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Huub J Poelman, Roger CW Wolfs, Wishal D Ramdas Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the NetherlandsCorrespondence: Wishal D RamdasDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, ‘S Gravendijkwal 230, CE 3015, Rotterdam, The NetherlandsEmail w.ramdas@erasmusmc.nlObjective: This review summarizes published findings concerning the Baerveldt-350 glaucoma drainage device (GDD). Most studies focus on the comparison between different treatments; in this review, the primary focus is efficacy, safety, and place in therapy for the Baerveldt implant.Methods: A systematic review was performed using the PubMed database for literature on March 13th, 2020. Efficacy was estimated by performing multiple meta-analyses to calculate the weighted mean difference in intraocular pressure (IOP) and IOP-lowering medication after surgery. In order to get an indication of the safety of the Baerveldt implant, all recorded peri- and postoperative complication were summarized.Results: A total of 21 studies, including 12 randomized controlled trials, were included with a follow-up up to 5 years, covering a mix of glaucoma types. At the last follow-up point, at 5 years postoperative, the mean (95% confidence interval) reduction in IOP was 15.57 mmHg (14.43– 16.71) and the mean (95% confidence interval) reduction in IOP-lowering medication after surgery was 1.81 (1.61– 2.01). Most frequently observed postoperative complications were corneal edema (2– 34%) and tube complications (4– 33%). Rates of required re-intervention ranged from 0% to 51% across all included studies.Conclusion: The efficacy of the Baerveldt implant is a significant reduction in IOP in the long term. The safety profile of the Baerveldt implant in terms of complication incidence is similar to those reported for other GDD’s. For treatment of secondary glaucoma, we suggest the Baerveldt (or any other similar GDD) as the choice of treatment in patients where highest IOP reduction is desired.Keywords: Baerveldt implant, glaucoma drainage device, glaucoma, intraocular pressurePoelman HJWolfs RCWRamdas WDDove Medical Pressarticlebaerveldt implantglaucoma drainage deviceglaucomaintraocular pressureOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 2789-2797 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	baerveldt implant glaucoma drainage device glaucoma intraocular pressure Ophthalmology RE1-994
spellingShingle	baerveldt implant glaucoma drainage device glaucoma intraocular pressure Ophthalmology RE1-994 Poelman HJ Wolfs RCW Ramdas WD The Baerveldt Glaucoma Drainage Device: Efficacy, Safety, and Place in Therapy
description	Huub J Poelman, Roger CW Wolfs, Wishal D Ramdas Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the NetherlandsCorrespondence: Wishal D RamdasDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, ‘S Gravendijkwal 230, CE 3015, Rotterdam, The NetherlandsEmail w.ramdas@erasmusmc.nlObjective: This review summarizes published findings concerning the Baerveldt-350 glaucoma drainage device (GDD). Most studies focus on the comparison between different treatments; in this review, the primary focus is efficacy, safety, and place in therapy for the Baerveldt implant.Methods: A systematic review was performed using the PubMed database for literature on March 13th, 2020. Efficacy was estimated by performing multiple meta-analyses to calculate the weighted mean difference in intraocular pressure (IOP) and IOP-lowering medication after surgery. In order to get an indication of the safety of the Baerveldt implant, all recorded peri- and postoperative complication were summarized.Results: A total of 21 studies, including 12 randomized controlled trials, were included with a follow-up up to 5 years, covering a mix of glaucoma types. At the last follow-up point, at 5 years postoperative, the mean (95% confidence interval) reduction in IOP was 15.57 mmHg (14.43– 16.71) and the mean (95% confidence interval) reduction in IOP-lowering medication after surgery was 1.81 (1.61– 2.01). Most frequently observed postoperative complications were corneal edema (2– 34%) and tube complications (4– 33%). Rates of required re-intervention ranged from 0% to 51% across all included studies.Conclusion: The efficacy of the Baerveldt implant is a significant reduction in IOP in the long term. The safety profile of the Baerveldt implant in terms of complication incidence is similar to those reported for other GDD’s. For treatment of secondary glaucoma, we suggest the Baerveldt (or any other similar GDD) as the choice of treatment in patients where highest IOP reduction is desired.Keywords: Baerveldt implant, glaucoma drainage device, glaucoma, intraocular pressure
format	article
author	Poelman HJ Wolfs RCW Ramdas WD
author_facet	Poelman HJ Wolfs RCW Ramdas WD
author_sort	Poelman HJ
title	The Baerveldt Glaucoma Drainage Device: Efficacy, Safety, and Place in Therapy
title_short	The Baerveldt Glaucoma Drainage Device: Efficacy, Safety, and Place in Therapy
title_full	The Baerveldt Glaucoma Drainage Device: Efficacy, Safety, and Place in Therapy
title_fullStr	The Baerveldt Glaucoma Drainage Device: Efficacy, Safety, and Place in Therapy
title_full_unstemmed	The Baerveldt Glaucoma Drainage Device: Efficacy, Safety, and Place in Therapy
title_sort	baerveldt glaucoma drainage device: efficacy, safety, and place in therapy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0df58b66e8db49d69099952b79789a1d
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The Baerveldt Glaucoma Drainage Device: Efficacy, Safety, and Place in Therapy

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