Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents

Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variat...

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Autores principales:	Fatme Al-Anouti, Mira Mousa, Spyridon N. Karras, William B. Grant, Zainab Alhalwachi, Laila Abdel-Wareth, Maimunah Uddin, Nawal Alkaabi, Guan K. Tay, Bassam Mahboub, Habiba AlSafar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vitamin D metabolism polymorphism COVID-19 UAE genotypes Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/0df7a711b8bc4f2d8d547a496b160496
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spelling	oai:doaj.org-article:0df7a711b8bc4f2d8d547a496b1604962021-11-25T18:33:07ZAssociations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents10.3390/nu131136802072-6643https://doaj.org/article/0df7a711b8bc4f2d8d547a496b1604962021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3680https://doaj.org/toc/2072-6643Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 (<i>n</i> = 453; 70.12%) and a critical group (<i>n</i> = 193; 29.87%). Genotype data on the GC, NADSYN1, VDR, and CYP2R1 genes along with data on serum 25-hydroxyvitamin D levels were compiled in patients admitted to a major hospital in the United Arab Emirates between April 2020 and January 2021. We identified 12 single-nucleotide polymorphisms associated with the critical COVID-19 condition: rs59241277, rs113574864, rs182901986, rs60349934, and rs113876500; rs4944076, rs4944997, rs4944998, rs4944979, and rs10898210; and rs11574018 and rs11574024. We report significant associations between genetic determinants of vitamin D metabolism and COVID-19 severity in the UAE population. Further research needed to clarify the mechanism of action against viral infection in vitamin D deficiency. These variants could be used with vaccination to manage the spread of SARS-CoV-2 and could be particularly valuable in populations in which vitamin D deficiency is common.Fatme Al-AnoutiMira MousaSpyridon N. KarrasWilliam B. GrantZainab AlhalwachiLaila Abdel-WarethMaimunah UddinNawal AlkaabiGuan K. TayBassam MahboubHabiba AlSafarMDPI AGarticlevitamin DmetabolismpolymorphismCOVID-19UAEgenotypesNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3680, p 3680 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin D metabolism polymorphism COVID-19 UAE genotypes Nutrition. Foods and food supply TX341-641
spellingShingle	vitamin D metabolism polymorphism COVID-19 UAE genotypes Nutrition. Foods and food supply TX341-641 Fatme Al-Anouti Mira Mousa Spyridon N. Karras William B. Grant Zainab Alhalwachi Laila Abdel-Wareth Maimunah Uddin Nawal Alkaabi Guan K. Tay Bassam Mahboub Habiba AlSafar Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents
description	Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 (<i>n</i> = 453; 70.12%) and a critical group (<i>n</i> = 193; 29.87%). Genotype data on the GC, NADSYN1, VDR, and CYP2R1 genes along with data on serum 25-hydroxyvitamin D levels were compiled in patients admitted to a major hospital in the United Arab Emirates between April 2020 and January 2021. We identified 12 single-nucleotide polymorphisms associated with the critical COVID-19 condition: rs59241277, rs113574864, rs182901986, rs60349934, and rs113876500; rs4944076, rs4944997, rs4944998, rs4944979, and rs10898210; and rs11574018 and rs11574024. We report significant associations between genetic determinants of vitamin D metabolism and COVID-19 severity in the UAE population. Further research needed to clarify the mechanism of action against viral infection in vitamin D deficiency. These variants could be used with vaccination to manage the spread of SARS-CoV-2 and could be particularly valuable in populations in which vitamin D deficiency is common.
format	article
author	Fatme Al-Anouti Mira Mousa Spyridon N. Karras William B. Grant Zainab Alhalwachi Laila Abdel-Wareth Maimunah Uddin Nawal Alkaabi Guan K. Tay Bassam Mahboub Habiba AlSafar
author_facet	Fatme Al-Anouti Mira Mousa Spyridon N. Karras William B. Grant Zainab Alhalwachi Laila Abdel-Wareth Maimunah Uddin Nawal Alkaabi Guan K. Tay Bassam Mahboub Habiba AlSafar
author_sort	Fatme Al-Anouti
title	Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents
title_short	Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents
title_full	Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents
title_fullStr	Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents
title_full_unstemmed	Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents
title_sort	associations between genetic variants in the vitamin d metabolism pathway and severity of covid-19 among uae residents
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0df7a711b8bc4f2d8d547a496b160496
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Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents

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