An extended APOBEC3A mutation signature in cancer

The APOBEC mutation signature contributes to a significant percentage of human cancers. Here the authors via biochemical and computational analyses shed light on how DNA primary sequence and secondary structure jointly influence A3A substrate optimality.

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Autores principales:	Adam Langenbucher, Danae Bowen, Ramin Sakhtemani, Elodie Bournique, Jillian F. Wise, Lee Zou, Ashok S. Bhagwat, Rémi Buisson, Michael S. Lawrence
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0df7d51a696e4dfaa11c6266dbb37d50
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spelling	oai:doaj.org-article:0df7d51a696e4dfaa11c6266dbb37d502021-12-02T13:35:00ZAn extended APOBEC3A mutation signature in cancer10.1038/s41467-021-21891-02041-1723https://doaj.org/article/0df7d51a696e4dfaa11c6266dbb37d502021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21891-0https://doaj.org/toc/2041-1723The APOBEC mutation signature contributes to a significant percentage of human cancers. Here the authors via biochemical and computational analyses shed light on how DNA primary sequence and secondary structure jointly influence A3A substrate optimality.Adam LangenbucherDanae BowenRamin SakhtemaniElodie BourniqueJillian F. WiseLee ZouAshok S. BhagwatRémi BuissonMichael S. LawrenceNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adam Langenbucher Danae Bowen Ramin Sakhtemani Elodie Bournique Jillian F. Wise Lee Zou Ashok S. Bhagwat Rémi Buisson Michael S. Lawrence An extended APOBEC3A mutation signature in cancer
description	The APOBEC mutation signature contributes to a significant percentage of human cancers. Here the authors via biochemical and computational analyses shed light on how DNA primary sequence and secondary structure jointly influence A3A substrate optimality.
format	article
author	Adam Langenbucher Danae Bowen Ramin Sakhtemani Elodie Bournique Jillian F. Wise Lee Zou Ashok S. Bhagwat Rémi Buisson Michael S. Lawrence
author_facet	Adam Langenbucher Danae Bowen Ramin Sakhtemani Elodie Bournique Jillian F. Wise Lee Zou Ashok S. Bhagwat Rémi Buisson Michael S. Lawrence
author_sort	Adam Langenbucher
title	An extended APOBEC3A mutation signature in cancer
title_short	An extended APOBEC3A mutation signature in cancer
title_full	An extended APOBEC3A mutation signature in cancer
title_fullStr	An extended APOBEC3A mutation signature in cancer
title_full_unstemmed	An extended APOBEC3A mutation signature in cancer
title_sort	extended apobec3a mutation signature in cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0df7d51a696e4dfaa11c6266dbb37d50
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An extended APOBEC3A mutation signature in cancer

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