Reduced amygdala and ventral striatal activity to happy faces in PTSD is associated with emotional numbing.

There has been a growing recognition of the importance of reward processing in PTSD, yet little is known of the underlying neural networks. This study tested the predictions that (1) individuals with PTSD would display reduced responses to happy facial expressions in ventral striatal reward networks...

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Autores principales:	Kim L Felmingham, Erin M Falconer, Leanne Williams, Andrew H Kemp, Adrian Allen, Anthony Peduto, Richard A Bryant
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0e05add2fcb841bda381358928cefbcd
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spelling	oai:doaj.org-article:0e05add2fcb841bda381358928cefbcd2021-11-25T06:02:04ZReduced amygdala and ventral striatal activity to happy faces in PTSD is associated with emotional numbing.1932-620310.1371/journal.pone.0103653https://doaj.org/article/0e05add2fcb841bda381358928cefbcd2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25184336/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203There has been a growing recognition of the importance of reward processing in PTSD, yet little is known of the underlying neural networks. This study tested the predictions that (1) individuals with PTSD would display reduced responses to happy facial expressions in ventral striatal reward networks, and (2) that this reduction would be associated with emotional numbing symptoms. 23 treatment-seeking patients with Posttraumatic Stress Disorder were recruited from the treatment clinic at the Centre for Traumatic Stress Studies, Westmead Hospital, and 20 trauma-exposed controls were recruited from a community sample. We examined functional magnetic resonance imaging responses during the presentation of happy and neutral facial expressions in a passive viewing task. PTSD participants rated happy facial expression as less intense than trauma-exposed controls. Relative to controls, PTSD participants revealed lower activation to happy (-neutral) faces in ventral striatum and and a trend for reduced activation in left amygdala. A significant negative correlation was found between emotional numbing symptoms in PTSD and right ventral striatal regions after controlling for depression, anxiety and PTSD severity. This study provides initial evidence that individuals with PTSD have lower reactivity to happy facial expressions, and that lower activation in ventral striatal-limbic reward networks may be associated with symptoms of emotional numbing.Kim L FelminghamErin M FalconerLeanne WilliamsAndrew H KempAdrian AllenAnthony PedutoRichard A BryantPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e103653 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kim L Felmingham Erin M Falconer Leanne Williams Andrew H Kemp Adrian Allen Anthony Peduto Richard A Bryant Reduced amygdala and ventral striatal activity to happy faces in PTSD is associated with emotional numbing.
description	There has been a growing recognition of the importance of reward processing in PTSD, yet little is known of the underlying neural networks. This study tested the predictions that (1) individuals with PTSD would display reduced responses to happy facial expressions in ventral striatal reward networks, and (2) that this reduction would be associated with emotional numbing symptoms. 23 treatment-seeking patients with Posttraumatic Stress Disorder were recruited from the treatment clinic at the Centre for Traumatic Stress Studies, Westmead Hospital, and 20 trauma-exposed controls were recruited from a community sample. We examined functional magnetic resonance imaging responses during the presentation of happy and neutral facial expressions in a passive viewing task. PTSD participants rated happy facial expression as less intense than trauma-exposed controls. Relative to controls, PTSD participants revealed lower activation to happy (-neutral) faces in ventral striatum and and a trend for reduced activation in left amygdala. A significant negative correlation was found between emotional numbing symptoms in PTSD and right ventral striatal regions after controlling for depression, anxiety and PTSD severity. This study provides initial evidence that individuals with PTSD have lower reactivity to happy facial expressions, and that lower activation in ventral striatal-limbic reward networks may be associated with symptoms of emotional numbing.
format	article
author	Kim L Felmingham Erin M Falconer Leanne Williams Andrew H Kemp Adrian Allen Anthony Peduto Richard A Bryant
author_facet	Kim L Felmingham Erin M Falconer Leanne Williams Andrew H Kemp Adrian Allen Anthony Peduto Richard A Bryant
author_sort	Kim L Felmingham
title	Reduced amygdala and ventral striatal activity to happy faces in PTSD is associated with emotional numbing.
title_short	Reduced amygdala and ventral striatal activity to happy faces in PTSD is associated with emotional numbing.
title_full	Reduced amygdala and ventral striatal activity to happy faces in PTSD is associated with emotional numbing.
title_fullStr	Reduced amygdala and ventral striatal activity to happy faces in PTSD is associated with emotional numbing.
title_full_unstemmed	Reduced amygdala and ventral striatal activity to happy faces in PTSD is associated with emotional numbing.
title_sort	reduced amygdala and ventral striatal activity to happy faces in ptsd is associated with emotional numbing.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/0e05add2fcb841bda381358928cefbcd
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Reduced amygdala and ventral striatal activity to happy faces in PTSD is associated with emotional numbing.

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