Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms

The medicinal herb Centella asiatica (L.) Urban known as gotu kola has been reported to exhibit a wide range of pharmacological activities. In particular, a significant body of scientific research exists on the therapeutic properties of preparations of C. asiatica or its triterpenes in the treatment...

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Autor principal:	Kyoung Sik Park
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/0e091319bf7a409f9c32e2ed1588a5d1
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spelling	oai:doaj.org-article:0e091319bf7a409f9c32e2ed1588a5d12021-11-29T00:56:48ZPharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms1741-428810.1155/2021/5462633https://doaj.org/article/0e091319bf7a409f9c32e2ed1588a5d12021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5462633https://doaj.org/toc/1741-4288The medicinal herb Centella asiatica (L.) Urban known as gotu kola has been reported to exhibit a wide range of pharmacological activities. In particular, a significant body of scientific research exists on the therapeutic properties of preparations of C. asiatica or its triterpenes in the treatment of skin diseases. The present study is aimed to provide a comprehensive overview of the beneficial effects of C. asiatica on skin diseases. Peer-reviewed articles on the potent dermatological effects of C. asiatica were acquired from PubMed, Web of Science, Scopus, ScienceDirect, and SciFinder. This review provides an understanding of pharmacological studies which confirm the potent dermatological effects and underlying molecular mechanisms of C. asiatica. This medicinal plant and its triterpenes include asiaticoside, madecassoside, and their aglycones, asiatic acid and madecassic acid. These compounds exert therapeutic effects on dermatological diseases such as acne, burns, atopic dermatitis, and wounds via NF-κB, TGF-β/Smad, MAPK, Wnt/β-catenin, and STAT signaling in in vitro and in vivo studies. However, additional rigorously controlled long-term clinical trials will be necessary to confirm the full potential of C. asiatica as a therapeutic agent.Kyoung Sik ParkHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Kyoung Sik Park Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms
description	The medicinal herb Centella asiatica (L.) Urban known as gotu kola has been reported to exhibit a wide range of pharmacological activities. In particular, a significant body of scientific research exists on the therapeutic properties of preparations of C. asiatica or its triterpenes in the treatment of skin diseases. The present study is aimed to provide a comprehensive overview of the beneficial effects of C. asiatica on skin diseases. Peer-reviewed articles on the potent dermatological effects of C. asiatica were acquired from PubMed, Web of Science, Scopus, ScienceDirect, and SciFinder. This review provides an understanding of pharmacological studies which confirm the potent dermatological effects and underlying molecular mechanisms of C. asiatica. This medicinal plant and its triterpenes include asiaticoside, madecassoside, and their aglycones, asiatic acid and madecassic acid. These compounds exert therapeutic effects on dermatological diseases such as acne, burns, atopic dermatitis, and wounds via NF-κB, TGF-β/Smad, MAPK, Wnt/β-catenin, and STAT signaling in in vitro and in vivo studies. However, additional rigorously controlled long-term clinical trials will be necessary to confirm the full potential of C. asiatica as a therapeutic agent.
format	article
author	Kyoung Sik Park
author_facet	Kyoung Sik Park
author_sort	Kyoung Sik Park
title	Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms
title_short	Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms
title_full	Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms
title_fullStr	Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms
title_full_unstemmed	Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms
title_sort	pharmacological effects of centella asiatica on skin diseases: evidence and possible mechanisms
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/0e091319bf7a409f9c32e2ed1588a5d1
work_keys_str_mv	AT kyoungsikpark pharmacologicaleffectsofcentellaasiaticaonskindiseasesevidenceandpossiblemechanisms
_version_	1718407630849835008

Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms

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