Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus

The degree of Treg self-antigen reactivity varies across experimental systems. Here the authors develop a new model of skin autoimmunity and show that the size of tissue-specific Treg pool in the thymus depends on AIRE, the availability of the tissue antigen, and its presentation by dendritic cells.

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Autores principales:	Jiqiang Lin, Lu Yang, Hernandez Moura Silva, Alissa Trzeciak, Yongwon Choi, Susan R. Schwab, Michael L. Dustin, Juan J. Lafaille
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e0b6c0f56ef4a0d8b0da62b638522a4
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spelling	oai:doaj.org-article:0e0b6c0f56ef4a0d8b0da62b638522a42021-12-02T14:38:35ZIncreased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus10.1038/ncomms105622041-1723https://doaj.org/article/0e0b6c0f56ef4a0d8b0da62b638522a42016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10562https://doaj.org/toc/2041-1723The degree of Treg self-antigen reactivity varies across experimental systems. Here the authors develop a new model of skin autoimmunity and show that the size of tissue-specific Treg pool in the thymus depends on AIRE, the availability of the tissue antigen, and its presentation by dendritic cells.Jiqiang LinLu YangHernandez Moura SilvaAlissa TrzeciakYongwon ChoiSusan R. SchwabMichael L. DustinJuan J. LafailleNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiqiang Lin Lu Yang Hernandez Moura Silva Alissa Trzeciak Yongwon Choi Susan R. Schwab Michael L. Dustin Juan J. Lafaille Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus
description	The degree of Treg self-antigen reactivity varies across experimental systems. Here the authors develop a new model of skin autoimmunity and show that the size of tissue-specific Treg pool in the thymus depends on AIRE, the availability of the tissue antigen, and its presentation by dendritic cells.
format	article
author	Jiqiang Lin Lu Yang Hernandez Moura Silva Alissa Trzeciak Yongwon Choi Susan R. Schwab Michael L. Dustin Juan J. Lafaille
author_facet	Jiqiang Lin Lu Yang Hernandez Moura Silva Alissa Trzeciak Yongwon Choi Susan R. Schwab Michael L. Dustin Juan J. Lafaille
author_sort	Jiqiang Lin
title	Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus
title_short	Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus
title_full	Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus
title_fullStr	Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus
title_full_unstemmed	Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus
title_sort	increased generation of foxp3+ regulatory t cells by manipulating antigen presentation in the thymus
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0e0b6c0f56ef4a0d8b0da62b638522a4
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Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus

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