Functional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract

Abstract Transforming growth factor β (TGFβ) signaling plays critical roles in reproductive development and function. TGFβ ligands signal through the TGFβ receptor type 2 (TGFBR2)/TGFBR1 complex. As TGFBR2 and TGFBR1 form a signaling complex upon ligand stimulation, they are expected to be equally i...

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Autores principales:	Nan Ni, Xin Fang, Qinglei Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0e0ba4ef0cde492b898776c28481f2ae
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spelling	oai:doaj.org-article:0e0ba4ef0cde492b898776c28481f2ae2021-12-02T17:39:31ZFunctional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract10.1038/s41598-021-88673-y2045-2322https://doaj.org/article/0e0ba4ef0cde492b898776c28481f2ae2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88673-yhttps://doaj.org/toc/2045-2322Abstract Transforming growth factor β (TGFβ) signaling plays critical roles in reproductive development and function. TGFβ ligands signal through the TGFβ receptor type 2 (TGFBR2)/TGFBR1 complex. As TGFBR2 and TGFBR1 form a signaling complex upon ligand stimulation, they are expected to be equally important for propagating TGFβ signaling that elicits cellular responses. However, several genetic studies challenge this concept and indicate that disruption of TGFBR2 or TGFBR1 may lead to contrasting phenotypic outcomes. We have shown that conditional deletion of Tgfbr1 using anti-Mullerian hormone receptor type 2 (Amhr2)-Cre causes oviductal and myometrial defects. To determine the functional requirement of TGFBR2 in the female reproductive tract and the potential phenotypic divergence/similarity resulting from conditional ablation of either receptor, we generated mice harboring Tgfbr2 deletion using the same Cre driver that was previously employed to target Tgfbr1. Herein, we found that conditional deletion of Tgfbr2 led to a similar phenotype to that of Tgfbr1 deletion in the female reproductive tract. Furthermore, genetic removal of Tgfbr1 in the Tgfbr2-deleted uterus had minimal impact on the phenotype of Tgfbr2 conditional knockout mice. In summary, our results reveal the functional similarity between TGFBR2 and TGFBR1 in maintaining the structural integrity of the female reproductive tract.Nan NiXin FangQinglei LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nan Ni Xin Fang Qinglei Li Functional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract
description	Abstract Transforming growth factor β (TGFβ) signaling plays critical roles in reproductive development and function. TGFβ ligands signal through the TGFβ receptor type 2 (TGFBR2)/TGFBR1 complex. As TGFBR2 and TGFBR1 form a signaling complex upon ligand stimulation, they are expected to be equally important for propagating TGFβ signaling that elicits cellular responses. However, several genetic studies challenge this concept and indicate that disruption of TGFBR2 or TGFBR1 may lead to contrasting phenotypic outcomes. We have shown that conditional deletion of Tgfbr1 using anti-Mullerian hormone receptor type 2 (Amhr2)-Cre causes oviductal and myometrial defects. To determine the functional requirement of TGFBR2 in the female reproductive tract and the potential phenotypic divergence/similarity resulting from conditional ablation of either receptor, we generated mice harboring Tgfbr2 deletion using the same Cre driver that was previously employed to target Tgfbr1. Herein, we found that conditional deletion of Tgfbr2 led to a similar phenotype to that of Tgfbr1 deletion in the female reproductive tract. Furthermore, genetic removal of Tgfbr1 in the Tgfbr2-deleted uterus had minimal impact on the phenotype of Tgfbr2 conditional knockout mice. In summary, our results reveal the functional similarity between TGFBR2 and TGFBR1 in maintaining the structural integrity of the female reproductive tract.
format	article
author	Nan Ni Xin Fang Qinglei Li
author_facet	Nan Ni Xin Fang Qinglei Li
author_sort	Nan Ni
title	Functional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract
title_short	Functional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract
title_full	Functional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract
title_fullStr	Functional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract
title_full_unstemmed	Functional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract
title_sort	functional similarity between tgf-beta type 2 and type 1 receptors in the female reproductive tract
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0e0ba4ef0cde492b898776c28481f2ae
work_keys_str_mv	AT nanni functionalsimilaritybetweentgfbetatype2andtype1receptorsinthefemalereproductivetract AT xinfang functionalsimilaritybetweentgfbetatype2andtype1receptorsinthefemalereproductivetract AT qingleili functionalsimilaritybetweentgfbetatype2andtype1receptorsinthefemalereproductivetract
_version_	1718379807484411904

Functional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract

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