Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection.
Reducing food intake is a common host response to infection, yet it remains unclear whether fasting is detrimental or beneficial to an infected host. Despite the gastrointestinal tract being the primary site of nutrient uptake and a common route for infection, studies have yet to examine how fasting...
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2021
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oai:doaj.org-article:0e0ea62074644ca3b0f075eb8663545f2021-12-02T20:00:25ZFasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection.1553-73661553-737410.1371/journal.ppat.1009719https://doaj.org/article/0e0ea62074644ca3b0f075eb8663545f2021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1009719https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Reducing food intake is a common host response to infection, yet it remains unclear whether fasting is detrimental or beneficial to an infected host. Despite the gastrointestinal tract being the primary site of nutrient uptake and a common route for infection, studies have yet to examine how fasting alters the host's response to an enteric infection. To test this, mice were fasted before and during oral infection with the invasive bacterium Salmonella enterica serovar Typhimurium. Fasting dramatically interrupted infection and subsequent gastroenteritis by suppressing Salmonella's SPI-1 virulence program, preventing invasion of the gut epithelium. Virulence suppression depended on the gut microbiota, as Salmonella's invasion of the epithelium proceeded in fasting gnotobiotic mice. Despite Salmonella's restored virulence within the intestines of gnotobiotic mice, fasting downregulated pro-inflammatory signaling, greatly reducing intestinal pathology. Our study highlights how food intake controls the complex relationship between host, pathogen and gut microbiota during an enteric infection.Franziska A GraefLarissa S CelibertoJoannie M AllaireMimi T Y KuanElse S BosmanShauna M CrowleyHyungjun YangJustin H ChanMartin StahlHongbing YuCandice QuinDeanna L GibsonElena F VerduKevan JacobsonBruce A VallancePublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 8, p e1009719 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 |
| spellingShingle |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Franziska A Graef Larissa S Celiberto Joannie M Allaire Mimi T Y Kuan Else S Bosman Shauna M Crowley Hyungjun Yang Justin H Chan Martin Stahl Hongbing Yu Candice Quin Deanna L Gibson Elena F Verdu Kevan Jacobson Bruce A Vallance Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection. |
| description |
Reducing food intake is a common host response to infection, yet it remains unclear whether fasting is detrimental or beneficial to an infected host. Despite the gastrointestinal tract being the primary site of nutrient uptake and a common route for infection, studies have yet to examine how fasting alters the host's response to an enteric infection. To test this, mice were fasted before and during oral infection with the invasive bacterium Salmonella enterica serovar Typhimurium. Fasting dramatically interrupted infection and subsequent gastroenteritis by suppressing Salmonella's SPI-1 virulence program, preventing invasion of the gut epithelium. Virulence suppression depended on the gut microbiota, as Salmonella's invasion of the epithelium proceeded in fasting gnotobiotic mice. Despite Salmonella's restored virulence within the intestines of gnotobiotic mice, fasting downregulated pro-inflammatory signaling, greatly reducing intestinal pathology. Our study highlights how food intake controls the complex relationship between host, pathogen and gut microbiota during an enteric infection. |
| format |
article |
| author |
Franziska A Graef Larissa S Celiberto Joannie M Allaire Mimi T Y Kuan Else S Bosman Shauna M Crowley Hyungjun Yang Justin H Chan Martin Stahl Hongbing Yu Candice Quin Deanna L Gibson Elena F Verdu Kevan Jacobson Bruce A Vallance |
| author_facet |
Franziska A Graef Larissa S Celiberto Joannie M Allaire Mimi T Y Kuan Else S Bosman Shauna M Crowley Hyungjun Yang Justin H Chan Martin Stahl Hongbing Yu Candice Quin Deanna L Gibson Elena F Verdu Kevan Jacobson Bruce A Vallance |
| author_sort |
Franziska A Graef |
| title |
Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection. |
| title_short |
Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection. |
| title_full |
Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection. |
| title_fullStr |
Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection. |
| title_full_unstemmed |
Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection. |
| title_sort |
fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/0e0ea62074644ca3b0f075eb8663545f |
| work_keys_str_mv |
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| _version_ |
1718375703648403456 |