Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement

Synthetic molecular systems require subtle control over their thermodynamics and reaction kinetics to implement features such as catalysis. Here the authors propose using mismatches in a DNA duplex to drive catalytic reactions forward whilst maintaining tight catalytic control.

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Autores principales: Natalie E. C. Haley, Thomas E. Ouldridge, Ismael Mullor Ruiz, Alessandro Geraldini, Ard A. Louis, Jonathan Bath, Andrew J. Turberfield
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/0e14c3f417da4a58968040c4405b62d2
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spelling oai:doaj.org-article:0e14c3f417da4a58968040c4405b62d22021-12-02T16:49:45ZDesign of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement10.1038/s41467-020-16353-y2041-1723https://doaj.org/article/0e14c3f417da4a58968040c4405b62d22020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16353-yhttps://doaj.org/toc/2041-1723Synthetic molecular systems require subtle control over their thermodynamics and reaction kinetics to implement features such as catalysis. Here the authors propose using mismatches in a DNA duplex to drive catalytic reactions forward whilst maintaining tight catalytic control.Natalie E. C. HaleyThomas E. OuldridgeIsmael Mullor RuizAlessandro GeraldiniArd A. LouisJonathan BathAndrew J. TurberfieldNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Natalie E. C. Haley
Thomas E. Ouldridge
Ismael Mullor Ruiz
Alessandro Geraldini
Ard A. Louis
Jonathan Bath
Andrew J. Turberfield
Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
description Synthetic molecular systems require subtle control over their thermodynamics and reaction kinetics to implement features such as catalysis. Here the authors propose using mismatches in a DNA duplex to drive catalytic reactions forward whilst maintaining tight catalytic control.
format article
author Natalie E. C. Haley
Thomas E. Ouldridge
Ismael Mullor Ruiz
Alessandro Geraldini
Ard A. Louis
Jonathan Bath
Andrew J. Turberfield
author_facet Natalie E. C. Haley
Thomas E. Ouldridge
Ismael Mullor Ruiz
Alessandro Geraldini
Ard A. Louis
Jonathan Bath
Andrew J. Turberfield
author_sort Natalie E. C. Haley
title Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
title_short Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
title_full Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
title_fullStr Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
title_full_unstemmed Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
title_sort design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during dna strand displacement
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/0e14c3f417da4a58968040c4405b62d2
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