Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement

Synthetic molecular systems require subtle control over their thermodynamics and reaction kinetics to implement features such as catalysis. Here the authors propose using mismatches in a DNA duplex to drive catalytic reactions forward whilst maintaining tight catalytic control.

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Bibliographic Details
Main Authors:	Natalie E. C. Haley, Thomas E. Ouldridge, Ismael Mullor Ruiz, Alessandro Geraldini, Ard A. Louis, Jonathan Bath, Andrew J. Turberfield
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/0e14c3f417da4a58968040c4405b62d2
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spelling	oai:doaj.org-article:0e14c3f417da4a58968040c4405b62d22021-12-02T16:49:45ZDesign of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement10.1038/s41467-020-16353-y2041-1723https://doaj.org/article/0e14c3f417da4a58968040c4405b62d22020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16353-yhttps://doaj.org/toc/2041-1723Synthetic molecular systems require subtle control over their thermodynamics and reaction kinetics to implement features such as catalysis. Here the authors propose using mismatches in a DNA duplex to drive catalytic reactions forward whilst maintaining tight catalytic control.Natalie E. C. HaleyThomas E. OuldridgeIsmael Mullor RuizAlessandro GeraldiniArd A. LouisJonathan BathAndrew J. TurberfieldNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Natalie E. C. Haley Thomas E. Ouldridge Ismael Mullor Ruiz Alessandro Geraldini Ard A. Louis Jonathan Bath Andrew J. Turberfield Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
description	Synthetic molecular systems require subtle control over their thermodynamics and reaction kinetics to implement features such as catalysis. Here the authors propose using mismatches in a DNA duplex to drive catalytic reactions forward whilst maintaining tight catalytic control.
format	article
author	Natalie E. C. Haley Thomas E. Ouldridge Ismael Mullor Ruiz Alessandro Geraldini Ard A. Louis Jonathan Bath Andrew J. Turberfield
author_facet	Natalie E. C. Haley Thomas E. Ouldridge Ismael Mullor Ruiz Alessandro Geraldini Ard A. Louis Jonathan Bath Andrew J. Turberfield
author_sort	Natalie E. C. Haley
title	Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
title_short	Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
title_full	Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
title_fullStr	Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
title_full_unstemmed	Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement
title_sort	design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during dna strand displacement
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0e14c3f417da4a58968040c4405b62d2
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Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement

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