Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages

Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages

Lung damage increases abdominal aortic aneurysm (AAA) incidence, but the mechanism was unclear. Here, the authors show that injured lungs leak HMGB1, increasing RIPK3 expression in arterial macrophages that subsequently alters mitochondrial function, leading to MMP12 expression and AAA development.

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Detalles Bibliográficos
Autores principales: Ludovic Boytard, Tarik Hadi, Michele Silvestro, Hengdong Qu, Andrew Kumpfbeck, Rayan Sleiman, Kissinger Hyppolite Fils, Dornazsadat Alebrahim, Francesco Boccalatte, Matthias Kugler, Annanina Corsica, Bruce E. Gelb, Glenn Jacobowitz, George Miller, Chiara Bellini, Jessica Oakes, Jean-Sébastien Silvestre, Lior Zangi, Bhama Ramkhelawon
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/0e153e3e2c704d8d91ffd8a89322f6f4
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Descripción
Sumario:Lung damage increases abdominal aortic aneurysm (AAA) incidence, but the mechanism was unclear. Here, the authors show that injured lungs leak HMGB1, increasing RIPK3 expression in arterial macrophages that subsequently alters mitochondrial function, leading to MMP12 expression and AAA development.

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