Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages

Lung damage increases abdominal aortic aneurysm (AAA) incidence, but the mechanism was unclear. Here, the authors show that injured lungs leak HMGB1, increasing RIPK3 expression in arterial macrophages that subsequently alters mitochondrial function, leading to MMP12 expression and AAA development.

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Autores principales:	Ludovic Boytard, Tarik Hadi, Michele Silvestro, Hengdong Qu, Andrew Kumpfbeck, Rayan Sleiman, Kissinger Hyppolite Fils, Dornazsadat Alebrahim, Francesco Boccalatte, Matthias Kugler, Annanina Corsica, Bruce E. Gelb, Glenn Jacobowitz, George Miller, Chiara Bellini, Jessica Oakes, Jean-Sébastien Silvestre, Lior Zangi, Bhama Ramkhelawon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e153e3e2c704d8d91ffd8a89322f6f4
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spelling	oai:doaj.org-article:0e153e3e2c704d8d91ffd8a89322f6f42021-12-02T16:35:13ZLung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages10.1038/s41467-020-18088-22041-1723https://doaj.org/article/0e153e3e2c704d8d91ffd8a89322f6f42020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18088-2https://doaj.org/toc/2041-1723Lung damage increases abdominal aortic aneurysm (AAA) incidence, but the mechanism was unclear. Here, the authors show that injured lungs leak HMGB1, increasing RIPK3 expression in arterial macrophages that subsequently alters mitochondrial function, leading to MMP12 expression and AAA development.Ludovic BoytardTarik HadiMichele SilvestroHengdong QuAndrew KumpfbeckRayan SleimanKissinger Hyppolite FilsDornazsadat AlebrahimFrancesco BoccalatteMatthias KuglerAnnanina CorsicaBruce E. GelbGlenn JacobowitzGeorge MillerChiara BelliniJessica OakesJean-Sébastien SilvestreLior ZangiBhama RamkhelawonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ludovic Boytard Tarik Hadi Michele Silvestro Hengdong Qu Andrew Kumpfbeck Rayan Sleiman Kissinger Hyppolite Fils Dornazsadat Alebrahim Francesco Boccalatte Matthias Kugler Annanina Corsica Bruce E. Gelb Glenn Jacobowitz George Miller Chiara Bellini Jessica Oakes Jean-Sébastien Silvestre Lior Zangi Bhama Ramkhelawon Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages
description	Lung damage increases abdominal aortic aneurysm (AAA) incidence, but the mechanism was unclear. Here, the authors show that injured lungs leak HMGB1, increasing RIPK3 expression in arterial macrophages that subsequently alters mitochondrial function, leading to MMP12 expression and AAA development.
format	article
author	Ludovic Boytard Tarik Hadi Michele Silvestro Hengdong Qu Andrew Kumpfbeck Rayan Sleiman Kissinger Hyppolite Fils Dornazsadat Alebrahim Francesco Boccalatte Matthias Kugler Annanina Corsica Bruce E. Gelb Glenn Jacobowitz George Miller Chiara Bellini Jessica Oakes Jean-Sébastien Silvestre Lior Zangi Bhama Ramkhelawon
author_facet	Ludovic Boytard Tarik Hadi Michele Silvestro Hengdong Qu Andrew Kumpfbeck Rayan Sleiman Kissinger Hyppolite Fils Dornazsadat Alebrahim Francesco Boccalatte Matthias Kugler Annanina Corsica Bruce E. Gelb Glenn Jacobowitz George Miller Chiara Bellini Jessica Oakes Jean-Sébastien Silvestre Lior Zangi Bhama Ramkhelawon
author_sort	Ludovic Boytard
title	Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages
title_short	Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages
title_full	Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages
title_fullStr	Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages
title_full_unstemmed	Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages
title_sort	lung-derived hmgb1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0e153e3e2c704d8d91ffd8a89322f6f4
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Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages

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