Identification of Streptococcus suis putative zoonotic virulence factors: A systematic review and genomic meta-analysis

Streptococcus suis is an emerging zoonotic pathogen. Over 100 putative virulence factors have been described, but it is unclear to what extent these virulence factors could contribute to zoonotic potential of S. suis. We identified all S. suis virulence factors studied in experimental models of huma...

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Autores principales:	Thomas J. Roodsant, Boas C.L. Van Der Putten, Sara M. Tamminga, Constance Schultsz, Kees C.H. Van Der Ark
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	streptococcus suis zoonoses virulence factor systematic review meta-analysis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/0e17d88454c344f29e220134a8bf2248
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spelling	oai:doaj.org-article:0e17d88454c344f29e220134a8bf22482021-12-01T14:40:59ZIdentification of Streptococcus suis putative zoonotic virulence factors: A systematic review and genomic meta-analysis2150-55942150-560810.1080/21505594.2021.1985760https://doaj.org/article/0e17d88454c344f29e220134a8bf22482021-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2021.1985760https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Streptococcus suis is an emerging zoonotic pathogen. Over 100 putative virulence factors have been described, but it is unclear to what extent these virulence factors could contribute to zoonotic potential of S. suis. We identified all S. suis virulence factors studied in experimental models of human origin in a systematic review and assessed their contribution to zoonotic potential in a subsequent genomic meta-analysis. PubMed and Scopus were searched for English-language articles that studied S. suis virulence published until 31 March 2021. Articles that analyzed a virulence factor by knockout mutation, purified protein, and/or recombinant protein in a model of human origin, were included. Data on virulence factor, strain characteristics, used human models and experimental outcomes were extracted. All publicly available S. suis genomes with available metadata on host, disease status and country of origin, were included in a genomic meta-analysis. We calculated the ratio of the prevalence of each virulence factor in human and pig isolates. We included 130 articles and 1703 S. suis genomes in the analysis. We identified 53 putative virulence factors that were encoded by genes which are part of the S. suis core genome and 26 factors that were at least twice as prevalent in human isolates as in pig isolates. Hhly3 and NisK/R were particularly enriched in human isolates, after stratification by genetic lineage and country of isolation. This systematic review and genomic meta-analysis have identified virulence factors that are likely to contribute to the zoonotic potential of S. suis.Thomas J. RoodsantBoas C.L. Van Der PuttenSara M. TammingaConstance SchultszKees C.H. Van Der ArkTaylor & Francis Grouparticlestreptococcus suiszoonosesvirulence factorsystematic reviewmeta-analysisInfectious and parasitic diseasesRC109-216ENVirulence, Vol 12, Iss 1, Pp 2787-2797 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	streptococcus suis zoonoses virulence factor systematic review meta-analysis Infectious and parasitic diseases RC109-216
spellingShingle	streptococcus suis zoonoses virulence factor systematic review meta-analysis Infectious and parasitic diseases RC109-216 Thomas J. Roodsant Boas C.L. Van Der Putten Sara M. Tamminga Constance Schultsz Kees C.H. Van Der Ark Identification of Streptococcus suis putative zoonotic virulence factors: A systematic review and genomic meta-analysis
description	Streptococcus suis is an emerging zoonotic pathogen. Over 100 putative virulence factors have been described, but it is unclear to what extent these virulence factors could contribute to zoonotic potential of S. suis. We identified all S. suis virulence factors studied in experimental models of human origin in a systematic review and assessed their contribution to zoonotic potential in a subsequent genomic meta-analysis. PubMed and Scopus were searched for English-language articles that studied S. suis virulence published until 31 March 2021. Articles that analyzed a virulence factor by knockout mutation, purified protein, and/or recombinant protein in a model of human origin, were included. Data on virulence factor, strain characteristics, used human models and experimental outcomes were extracted. All publicly available S. suis genomes with available metadata on host, disease status and country of origin, were included in a genomic meta-analysis. We calculated the ratio of the prevalence of each virulence factor in human and pig isolates. We included 130 articles and 1703 S. suis genomes in the analysis. We identified 53 putative virulence factors that were encoded by genes which are part of the S. suis core genome and 26 factors that were at least twice as prevalent in human isolates as in pig isolates. Hhly3 and NisK/R were particularly enriched in human isolates, after stratification by genetic lineage and country of isolation. This systematic review and genomic meta-analysis have identified virulence factors that are likely to contribute to the zoonotic potential of S. suis.
format	article
author	Thomas J. Roodsant Boas C.L. Van Der Putten Sara M. Tamminga Constance Schultsz Kees C.H. Van Der Ark
author_facet	Thomas J. Roodsant Boas C.L. Van Der Putten Sara M. Tamminga Constance Schultsz Kees C.H. Van Der Ark
author_sort	Thomas J. Roodsant
title	Identification of Streptococcus suis putative zoonotic virulence factors: A systematic review and genomic meta-analysis
title_short	Identification of Streptococcus suis putative zoonotic virulence factors: A systematic review and genomic meta-analysis
title_full	Identification of Streptococcus suis putative zoonotic virulence factors: A systematic review and genomic meta-analysis
title_fullStr	Identification of Streptococcus suis putative zoonotic virulence factors: A systematic review and genomic meta-analysis
title_full_unstemmed	Identification of Streptococcus suis putative zoonotic virulence factors: A systematic review and genomic meta-analysis
title_sort	identification of streptococcus suis putative zoonotic virulence factors: a systematic review and genomic meta-analysis
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/0e17d88454c344f29e220134a8bf2248
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Identification of Streptococcus suis putative zoonotic virulence factors: A systematic review and genomic meta-analysis

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