Insights Into Central Nervous System Glial Cell Formation and Function From Zebrafish

The term glia describes a heterogenous collection of distinct cell types that make up a large proportion of our nervous system. Although once considered the glue of the nervous system, the study of glial cells has evolved significantly in recent years, with a large body of literature now highlightin...

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Autores principales:	Sarah A. Neely, David A. Lyons
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	zebrafish radial glia Müller glia astrocyte OPC oligodendrocyte Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0e1a8944236a4b55a2f7964a5db39913
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spelling	oai:doaj.org-article:0e1a8944236a4b55a2f7964a5db399132021-12-01T11:28:48ZInsights Into Central Nervous System Glial Cell Formation and Function From Zebrafish2296-634X10.3389/fcell.2021.754606https://doaj.org/article/0e1a8944236a4b55a2f7964a5db399132021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.754606/fullhttps://doaj.org/toc/2296-634XThe term glia describes a heterogenous collection of distinct cell types that make up a large proportion of our nervous system. Although once considered the glue of the nervous system, the study of glial cells has evolved significantly in recent years, with a large body of literature now highlighting their complex and diverse roles in development and throughout life. This progress is due, in part, to advances in animal models in which the molecular and cellular mechanisms of glial cell development and function as well as neuron-glial cell interactions can be directly studied in vivo in real time, in intact neural circuits. In this review we highlight the instrumental role that zebrafish have played as a vertebrate model system for the study of glial cells, and discuss how the experimental advantages of the zebrafish lend themselves to investigate glial cell interactions and diversity. We focus in particular on recent studies that have provided insight into the formation and function of the major glial cell types in the central nervous system in zebrafish.Sarah A. NeelyDavid A. LyonsFrontiers Media S.A.articlezebrafishradial gliaMüller gliaastrocyteOPColigodendrocyteBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	zebrafish radial glia Müller glia astrocyte OPC oligodendrocyte Biology (General) QH301-705.5
spellingShingle	zebrafish radial glia Müller glia astrocyte OPC oligodendrocyte Biology (General) QH301-705.5 Sarah A. Neely David A. Lyons Insights Into Central Nervous System Glial Cell Formation and Function From Zebrafish
description	The term glia describes a heterogenous collection of distinct cell types that make up a large proportion of our nervous system. Although once considered the glue of the nervous system, the study of glial cells has evolved significantly in recent years, with a large body of literature now highlighting their complex and diverse roles in development and throughout life. This progress is due, in part, to advances in animal models in which the molecular and cellular mechanisms of glial cell development and function as well as neuron-glial cell interactions can be directly studied in vivo in real time, in intact neural circuits. In this review we highlight the instrumental role that zebrafish have played as a vertebrate model system for the study of glial cells, and discuss how the experimental advantages of the zebrafish lend themselves to investigate glial cell interactions and diversity. We focus in particular on recent studies that have provided insight into the formation and function of the major glial cell types in the central nervous system in zebrafish.
format	article
author	Sarah A. Neely David A. Lyons
author_facet	Sarah A. Neely David A. Lyons
author_sort	Sarah A. Neely
title	Insights Into Central Nervous System Glial Cell Formation and Function From Zebrafish
title_short	Insights Into Central Nervous System Glial Cell Formation and Function From Zebrafish
title_full	Insights Into Central Nervous System Glial Cell Formation and Function From Zebrafish
title_fullStr	Insights Into Central Nervous System Glial Cell Formation and Function From Zebrafish
title_full_unstemmed	Insights Into Central Nervous System Glial Cell Formation and Function From Zebrafish
title_sort	insights into central nervous system glial cell formation and function from zebrafish
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0e1a8944236a4b55a2f7964a5db39913
work_keys_str_mv	AT sarahaneely insightsintocentralnervoussystemglialcellformationandfunctionfromzebrafish AT davidalyons insightsintocentralnervoussystemglialcellformationandfunctionfromzebrafish
_version_	1718405217732526080

Insights Into Central Nervous System Glial Cell Formation and Function From Zebrafish

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