Monte Carlo and analytic simulations in nanoparticle-enhanced radiation therapy

Autumn D Paro,1 Mainul Hossain,2 Thomas J Webster,1,3,4 Ming Su1,4 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2NanoScience Technology Center and School of Electrical Engineering and Computer Science, University of Central Florida, Orlando, Florida, USA; 3Excellen...

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Autores principales:	Paro AD, Hossain M, Webster TJ, Su M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	nanoparticle dose enhancement Monte Carlo simulation analytical simulation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0e1edd1159c44a66ae4418663abeef9a
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spelling	oai:doaj.org-article:0e1edd1159c44a66ae4418663abeef9a2021-12-02T00:38:48ZMonte Carlo and analytic simulations in nanoparticle-enhanced radiation therapy1178-2013https://doaj.org/article/0e1edd1159c44a66ae4418663abeef9a2016-09-01T00:00:00Zhttps://www.dovepress.com/monte-carlo-and-analytic-simulations-in-nanoparticle-enhanced-radiatio-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Autumn D Paro,1 Mainul Hossain,2 Thomas J Webster,1,3,4 Ming Su1,4 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2NanoScience Technology Center and School of Electrical Engineering and Computer Science, University of Central Florida, Orlando, Florida, USA; 3Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia; 4Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Science, Wenzhou Medical University, Zhejiang, People’s Republic of China Abstract: Analytical and Monte Carlo simulations have been used to predict dose enhancement factors in nanoparticle-enhanced X-ray radiation therapy. Both simulations predict an increase in dose enhancement in the presence of nanoparticles, but the two methods predict different levels of enhancement over the studied energy, nanoparticle materials, and concentration regime for several reasons. The Monte Carlo simulation calculates energy deposited by electrons and photons, while the analytical one only calculates energy deposited by source photons and photoelectrons; the Monte Carlo simulation accounts for electron–hole recombination, while the analytical one does not; and the Monte Carlo simulation randomly samples photon or electron path and accounts for particle interactions, while the analytical simulation assumes a linear trajectory. This study demonstrates that the Monte Carlo simulation will be a better choice to evaluate dose enhancement with nanoparticles in radiation therapy. Keywords: nanoparticle, dose enhancement, Monte Carlo simulation, analytical simulation, radiation therapy, tumor cell, X-ray Paro ADHossain MWebster TJSu MDove Medical Pressarticlenanoparticledose enhancementMonte Carlo simulationanalytical simulationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4735-4741 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticle dose enhancement Monte Carlo simulation analytical simulation Medicine (General) R5-920
spellingShingle	nanoparticle dose enhancement Monte Carlo simulation analytical simulation Medicine (General) R5-920 Paro AD Hossain M Webster TJ Su M Monte Carlo and analytic simulations in nanoparticle-enhanced radiation therapy
description	Autumn D Paro,1 Mainul Hossain,2 Thomas J Webster,1,3,4 Ming Su1,4 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2NanoScience Technology Center and School of Electrical Engineering and Computer Science, University of Central Florida, Orlando, Florida, USA; 3Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia; 4Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Science, Wenzhou Medical University, Zhejiang, People’s Republic of China Abstract: Analytical and Monte Carlo simulations have been used to predict dose enhancement factors in nanoparticle-enhanced X-ray radiation therapy. Both simulations predict an increase in dose enhancement in the presence of nanoparticles, but the two methods predict different levels of enhancement over the studied energy, nanoparticle materials, and concentration regime for several reasons. The Monte Carlo simulation calculates energy deposited by electrons and photons, while the analytical one only calculates energy deposited by source photons and photoelectrons; the Monte Carlo simulation accounts for electron–hole recombination, while the analytical one does not; and the Monte Carlo simulation randomly samples photon or electron path and accounts for particle interactions, while the analytical simulation assumes a linear trajectory. This study demonstrates that the Monte Carlo simulation will be a better choice to evaluate dose enhancement with nanoparticles in radiation therapy. Keywords: nanoparticle, dose enhancement, Monte Carlo simulation, analytical simulation, radiation therapy, tumor cell, X-ray
format	article
author	Paro AD Hossain M Webster TJ Su M
author_facet	Paro AD Hossain M Webster TJ Su M
author_sort	Paro AD
title	Monte Carlo and analytic simulations in nanoparticle-enhanced radiation therapy
title_short	Monte Carlo and analytic simulations in nanoparticle-enhanced radiation therapy
title_full	Monte Carlo and analytic simulations in nanoparticle-enhanced radiation therapy
title_fullStr	Monte Carlo and analytic simulations in nanoparticle-enhanced radiation therapy
title_full_unstemmed	Monte Carlo and analytic simulations in nanoparticle-enhanced radiation therapy
title_sort	monte carlo and analytic simulations in nanoparticle-enhanced radiation therapy
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/0e1edd1159c44a66ae4418663abeef9a
work_keys_str_mv	AT paroad montecarloandanalyticsimulationsinnanoparticleenhancedradiationtherapy AT hossainm montecarloandanalyticsimulationsinnanoparticleenhancedradiationtherapy AT webstertj montecarloandanalyticsimulationsinnanoparticleenhancedradiationtherapy AT sum montecarloandanalyticsimulationsinnanoparticleenhancedradiationtherapy
_version_	1718403538826035200

Monte Carlo and analytic simulations in nanoparticle-enhanced radiation therapy

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