A single NaK channel conformation is not enough for non-selective ion conduction

NaK is a non-selective cation channel that conducts sodium (Na+) and potassium (K+) equally well. Here authors use ssNMR and MD simulations to show that the selectivity filter of NaK adopts two conformations in the absence of ions, one of which is preferred by Na+ and the other by K+.

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Autores principales:	Chaowei Shi, Yao He, Kitty Hendriks, Bert L. de Groot, Xiaoying Cai, Changlin Tian, Adam Lange, Han Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e20ab2b76714568a57a0701df6d9902
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id	oai:doaj.org-article:0e20ab2b76714568a57a0701df6d9902
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spelling	oai:doaj.org-article:0e20ab2b76714568a57a0701df6d99022021-12-02T17:33:15ZA single NaK channel conformation is not enough for non-selective ion conduction10.1038/s41467-018-03179-y2041-1723https://doaj.org/article/0e20ab2b76714568a57a0701df6d99022018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03179-yhttps://doaj.org/toc/2041-1723NaK is a non-selective cation channel that conducts sodium (Na+) and potassium (K+) equally well. Here authors use ssNMR and MD simulations to show that the selectivity filter of NaK adopts two conformations in the absence of ions, one of which is preferred by Na+ and the other by K+.Chaowei ShiYao HeKitty HendriksBert L. de GrootXiaoying CaiChanglin TianAdam LangeHan SunNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chaowei Shi Yao He Kitty Hendriks Bert L. de Groot Xiaoying Cai Changlin Tian Adam Lange Han Sun A single NaK channel conformation is not enough for non-selective ion conduction
description	NaK is a non-selective cation channel that conducts sodium (Na+) and potassium (K+) equally well. Here authors use ssNMR and MD simulations to show that the selectivity filter of NaK adopts two conformations in the absence of ions, one of which is preferred by Na+ and the other by K+.
format	article
author	Chaowei Shi Yao He Kitty Hendriks Bert L. de Groot Xiaoying Cai Changlin Tian Adam Lange Han Sun
author_facet	Chaowei Shi Yao He Kitty Hendriks Bert L. de Groot Xiaoying Cai Changlin Tian Adam Lange Han Sun
author_sort	Chaowei Shi
title	A single NaK channel conformation is not enough for non-selective ion conduction
title_short	A single NaK channel conformation is not enough for non-selective ion conduction
title_full	A single NaK channel conformation is not enough for non-selective ion conduction
title_fullStr	A single NaK channel conformation is not enough for non-selective ion conduction
title_full_unstemmed	A single NaK channel conformation is not enough for non-selective ion conduction
title_sort	single nak channel conformation is not enough for non-selective ion conduction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0e20ab2b76714568a57a0701df6d9902
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A single NaK channel conformation is not enough for non-selective ion conduction

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