Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms
Most expression QTLs (eQTLs) co-occur with a DNA methylation QTL (meQTL), suggesting a common causal variant. Here the authors analyse DNA and RNA from blood and identify eQTL-meQTL pairs likely to share a causal variant, finding that expression and methylation are often genetically co-regulated.
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Nature Portfolio
2018
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oai:doaj.org-article:0e237f531ba64865aebc696a3861462b2021-12-02T14:40:55ZCo-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms10.1038/s41467-018-03209-92041-1723https://doaj.org/article/0e237f531ba64865aebc696a3861462b2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03209-9https://doaj.org/toc/2041-1723Most expression QTLs (eQTLs) co-occur with a DNA methylation QTL (meQTL), suggesting a common causal variant. Here the authors analyse DNA and RNA from blood and identify eQTL-meQTL pairs likely to share a causal variant, finding that expression and methylation are often genetically co-regulated.Brandon L. PierceLin TongMaria ArgosKathryn DemanelisFarzana JasmineMuhammad Rakibuz-ZamanGolam SarwarMd. Tariqul IslamHasan ShahriarTariqul IslamMahfuzar RahmanMd. YunusMuhammad G. KibriyaLin S. ChenHabibul AhsanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Brandon L. Pierce Lin Tong Maria Argos Kathryn Demanelis Farzana Jasmine Muhammad Rakibuz-Zaman Golam Sarwar Md. Tariqul Islam Hasan Shahriar Tariqul Islam Mahfuzar Rahman Md. Yunus Muhammad G. Kibriya Lin S. Chen Habibul Ahsan Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms |
| description |
Most expression QTLs (eQTLs) co-occur with a DNA methylation QTL (meQTL), suggesting a common causal variant. Here the authors analyse DNA and RNA from blood and identify eQTL-meQTL pairs likely to share a causal variant, finding that expression and methylation are often genetically co-regulated. |
| format |
article |
| author |
Brandon L. Pierce Lin Tong Maria Argos Kathryn Demanelis Farzana Jasmine Muhammad Rakibuz-Zaman Golam Sarwar Md. Tariqul Islam Hasan Shahriar Tariqul Islam Mahfuzar Rahman Md. Yunus Muhammad G. Kibriya Lin S. Chen Habibul Ahsan |
| author_facet |
Brandon L. Pierce Lin Tong Maria Argos Kathryn Demanelis Farzana Jasmine Muhammad Rakibuz-Zaman Golam Sarwar Md. Tariqul Islam Hasan Shahriar Tariqul Islam Mahfuzar Rahman Md. Yunus Muhammad G. Kibriya Lin S. Chen Habibul Ahsan |
| author_sort |
Brandon L. Pierce |
| title |
Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms |
| title_short |
Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms |
| title_full |
Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms |
| title_fullStr |
Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms |
| title_full_unstemmed |
Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms |
| title_sort |
co-occurring expression and methylation qtls allow detection of common causal variants and shared biological mechanisms |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/0e237f531ba64865aebc696a3861462b |
| work_keys_str_mv |
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