Systemic muscle wasting and coordinated tumour response drive tumourigenesis

Cancer is a systemic disease that associates with host metabolic changes. Here, the authors show using Drosophila, that tumours exploit extracellular proline in response to muscle wasting, indicating that tumours induce muscle wasting as a nutrient-scavenging programme to drive tumourigenesis.

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Autores principales:	Holly Newton, Yi-Fang Wang, Laura Camplese, Joao B. Mokochinski, Holger B. Kramer, André E. X. Brown, Louise Fets, Susumu Hirabayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e28b218bcbf4e1a9a38907a77d327a9
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spelling	oai:doaj.org-article:0e28b218bcbf4e1a9a38907a77d327a92021-12-02T18:02:24ZSystemic muscle wasting and coordinated tumour response drive tumourigenesis10.1038/s41467-020-18502-92041-1723https://doaj.org/article/0e28b218bcbf4e1a9a38907a77d327a92020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18502-9https://doaj.org/toc/2041-1723Cancer is a systemic disease that associates with host metabolic changes. Here, the authors show using Drosophila, that tumours exploit extracellular proline in response to muscle wasting, indicating that tumours induce muscle wasting as a nutrient-scavenging programme to drive tumourigenesis.Holly NewtonYi-Fang WangLaura CampleseJoao B. MokochinskiHolger B. KramerAndré E. X. BrownLouise FetsSusumu HirabayashiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Holly Newton Yi-Fang Wang Laura Camplese Joao B. Mokochinski Holger B. Kramer André E. X. Brown Louise Fets Susumu Hirabayashi Systemic muscle wasting and coordinated tumour response drive tumourigenesis
description	Cancer is a systemic disease that associates with host metabolic changes. Here, the authors show using Drosophila, that tumours exploit extracellular proline in response to muscle wasting, indicating that tumours induce muscle wasting as a nutrient-scavenging programme to drive tumourigenesis.
format	article
author	Holly Newton Yi-Fang Wang Laura Camplese Joao B. Mokochinski Holger B. Kramer André E. X. Brown Louise Fets Susumu Hirabayashi
author_facet	Holly Newton Yi-Fang Wang Laura Camplese Joao B. Mokochinski Holger B. Kramer André E. X. Brown Louise Fets Susumu Hirabayashi
author_sort	Holly Newton
title	Systemic muscle wasting and coordinated tumour response drive tumourigenesis
title_short	Systemic muscle wasting and coordinated tumour response drive tumourigenesis
title_full	Systemic muscle wasting and coordinated tumour response drive tumourigenesis
title_fullStr	Systemic muscle wasting and coordinated tumour response drive tumourigenesis
title_full_unstemmed	Systemic muscle wasting and coordinated tumour response drive tumourigenesis
title_sort	systemic muscle wasting and coordinated tumour response drive tumourigenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0e28b218bcbf4e1a9a38907a77d327a9
work_keys_str_mv	AT hollynewton systemicmusclewastingandcoordinatedtumourresponsedrivetumourigenesis AT yifangwang systemicmusclewastingandcoordinatedtumourresponsedrivetumourigenesis AT lauracamplese systemicmusclewastingandcoordinatedtumourresponsedrivetumourigenesis AT joaobmokochinski systemicmusclewastingandcoordinatedtumourresponsedrivetumourigenesis AT holgerbkramer systemicmusclewastingandcoordinatedtumourresponsedrivetumourigenesis AT andreexbrown systemicmusclewastingandcoordinatedtumourresponsedrivetumourigenesis AT louisefets systemicmusclewastingandcoordinatedtumourresponsedrivetumourigenesis AT susumuhirabayashi systemicmusclewastingandcoordinatedtumourresponsedrivetumourigenesis
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Systemic muscle wasting and coordinated tumour response drive tumourigenesis

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