Two-year treatment patterns and costs in glaucoma patients initiating treatment with prostaglandin analogs

Jordana K Schmier1, Edmund C Lau2, David W Covert31Exponent, Alexandria, VI, USA; 2Exponent, Menlo Park, CA, USA; 3Alcon Research Ltd, Fort Worth, TX, USAObjective: To determine treatment patterns and costs over a two-year period among new initiators of topical prostaglandin analogs in a managed car...

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Autores principales:	Jordana K Schmier, Edmund C Lau, David W Covert
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/0e29fc393acf4caa8c5b2c347f15d022
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spelling	oai:doaj.org-article:0e29fc393acf4caa8c5b2c347f15d0222021-12-02T06:31:53ZTwo-year treatment patterns and costs in glaucoma patients initiating treatment with prostaglandin analogs1177-54671177-5483https://doaj.org/article/0e29fc393acf4caa8c5b2c347f15d0222010-09-01T00:00:00Zhttp://www.dovepress.com/two-year-treatment-patterns-and-costs-in-glaucoma-patients-initiating--a5405https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Jordana K Schmier1, Edmund C Lau2, David W Covert31Exponent, Alexandria, VI, USA; 2Exponent, Menlo Park, CA, USA; 3Alcon Research Ltd, Fort Worth, TX, USAObjective: To determine treatment patterns and costs over a two-year period among new initiators of topical prostaglandin analogs in a managed care population by retrospective cohort analysis of an insurance claims database.Methods: Patients who initiated therapy with a prostaglandin analog between September 2006 and March 2007 were identified. The use of monotherapy and adjunctive therapies were compared by index prostaglandin. Days to initiation of adjunctive therapy and rates of glaucoma surgical procedures were also calculated. Medical costs (antiglaucoma medications and ophthalmic visits) over the two-year period were estimated.Results: The analysis identified 5018 patients with at least one prostaglandin analog prescription (bimatoprost, n = 747; latanoprost, n = 1651; benzalkonium chloride (BAK)-free travoprost, n = 203). The majority (51%&ndash;54%) had repeat prescriptions. Among those with repeat prescriptions, 52% were female (not significant) and mean age was 64 years (P &lt; 0.01). Rates of adjunctive therapy use varied across groups (bimatoprost 51%, latanoprost 37%, and BAK-free travoprost 35%, P &lt; 0.0001). Median and mean days to initiation of adjunctive therapy were 83 and 140 for bimatoprost, 101 and 181 for latanoprost, and 113 and 221 for BAK-free travoprost. Two-year medical costs were $3147, $2843, and $2557 for patients initiating treatment with bimatoprost, latanoprost, and BAK-free travoprost, respectively. Use of glaucoma surgical procedures across the treatment groups was similar over the two-year period.Conclusions: Over a two-year period, the rate and time to initiation of adjunctive therapy use, as well as medical costs, varied between index prostaglandins. However, the rate of glaucoma surgical interventions did not vary significantly across index medications.Keywords: costs and cost analysis, drug therapy, combination, glaucoma, prostaglandin analogs Jordana K SchmierEdmund C LauDavid W CovertDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 1137-1143 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Jordana K Schmier Edmund C Lau David W Covert Two-year treatment patterns and costs in glaucoma patients initiating treatment with prostaglandin analogs
description	Jordana K Schmier1, Edmund C Lau2, David W Covert31Exponent, Alexandria, VI, USA; 2Exponent, Menlo Park, CA, USA; 3Alcon Research Ltd, Fort Worth, TX, USAObjective: To determine treatment patterns and costs over a two-year period among new initiators of topical prostaglandin analogs in a managed care population by retrospective cohort analysis of an insurance claims database.Methods: Patients who initiated therapy with a prostaglandin analog between September 2006 and March 2007 were identified. The use of monotherapy and adjunctive therapies were compared by index prostaglandin. Days to initiation of adjunctive therapy and rates of glaucoma surgical procedures were also calculated. Medical costs (antiglaucoma medications and ophthalmic visits) over the two-year period were estimated.Results: The analysis identified 5018 patients with at least one prostaglandin analog prescription (bimatoprost, n = 747; latanoprost, n = 1651; benzalkonium chloride (BAK)-free travoprost, n = 203). The majority (51%&ndash;54%) had repeat prescriptions. Among those with repeat prescriptions, 52% were female (not significant) and mean age was 64 years (P &lt; 0.01). Rates of adjunctive therapy use varied across groups (bimatoprost 51%, latanoprost 37%, and BAK-free travoprost 35%, P &lt; 0.0001). Median and mean days to initiation of adjunctive therapy were 83 and 140 for bimatoprost, 101 and 181 for latanoprost, and 113 and 221 for BAK-free travoprost. Two-year medical costs were $3147, $2843, and $2557 for patients initiating treatment with bimatoprost, latanoprost, and BAK-free travoprost, respectively. Use of glaucoma surgical procedures across the treatment groups was similar over the two-year period.Conclusions: Over a two-year period, the rate and time to initiation of adjunctive therapy use, as well as medical costs, varied between index prostaglandins. However, the rate of glaucoma surgical interventions did not vary significantly across index medications.Keywords: costs and cost analysis, drug therapy, combination, glaucoma, prostaglandin analogs
format	article
author	Jordana K Schmier Edmund C Lau David W Covert
author_facet	Jordana K Schmier Edmund C Lau David W Covert
author_sort	Jordana K Schmier
title	Two-year treatment patterns and costs in glaucoma patients initiating treatment with prostaglandin analogs
title_short	Two-year treatment patterns and costs in glaucoma patients initiating treatment with prostaglandin analogs
title_full	Two-year treatment patterns and costs in glaucoma patients initiating treatment with prostaglandin analogs
title_fullStr	Two-year treatment patterns and costs in glaucoma patients initiating treatment with prostaglandin analogs
title_full_unstemmed	Two-year treatment patterns and costs in glaucoma patients initiating treatment with prostaglandin analogs
title_sort	two-year treatment patterns and costs in glaucoma patients initiating treatment with prostaglandin analogs
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/0e29fc393acf4caa8c5b2c347f15d022
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_version_	1718399857360633856

Two-year treatment patterns and costs in glaucoma patients initiating treatment with prostaglandin analogs

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