Higher lung accumulation of intravenously injected organic nanotubes

Yoshie Maitani,1 Yuri Nakamura,1 Masao Kon,1 Emi Sanada,1 Kae Sumiyoshi,1 Natsuki Fujine,1 Masumi Asakawa,2 Masaki Kogiso,2 Toshimi Shimizu21Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan; 2Nanotube Research Center (NTRC), National Institute of Advanced Industrial Science and Techn...

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Autores principales:	Maitani Y, Nakamura Y, Kon M, Sanada E, Sumiyoshi K, Fujine N, Asakawa M, Kogiso M, Shimizu T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0e2aba36a2f244a8a4d4c80b4cd42104
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spelling	oai:doaj.org-article:0e2aba36a2f244a8a4d4c80b4cd421042021-12-02T07:45:07ZHigher lung accumulation of intravenously injected organic nanotubes1176-91141178-2013https://doaj.org/article/0e2aba36a2f244a8a4d4c80b4cd421042013-01-01T00:00:00Zhttp://www.dovepress.com/higher-lung-accumulation-of-intravenously-injected-organic-nanotubes-a12000https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yoshie Maitani,1 Yuri Nakamura,1 Masao Kon,1 Emi Sanada,1 Kae Sumiyoshi,1 Natsuki Fujine,1 Masumi Asakawa,2 Masaki Kogiso,2 Toshimi Shimizu21Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan; 2Nanotube Research Center (NTRC), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, JapanAbstract: The size and shape of intravenously injected particles can affect their biodistribution and is of importance for the development of particulated drug carrier systems. In this study, organic nanotubes (ONTs) with a carboxyl group at the surface, a length of approximately 2 &micro;m and outer diameter of 70&ndash;90 nm, were injected intravenously into tumor-bearing mice. To use ONTs as drug carriers, the biodistribution in selected organs of ONTs postinjection was examined using irinotecan, as an entrapped water-soluble marker inside ONTs, and gadolinium-chelated ONT, as an ONT marker, and compared with that of a 3 &micro;m fluorescently labeled spherical microparticle which was similar size to the length of ONTs. It was found that for irinotecan, its active metabolite and gadolinium-chelated ONTs were highly accumulated in the lung, but to a lower level in the liver and spleen. On the other hand, microparticles deposited less in the lung and more highly in the liver. Moreover, histologic examination showed ONTs distributed more in lung tissues in part, whereas microparticles were present in blood vessels postinjection. These preliminary results support the notion of using negatively charged ONTs as intravascular carriers to maximize accumulation in the lung whilst reducing sequestration by the liver and spleen. This finding suggested that ONTs are potential carriers for lung-targeting drug delivery.Keywords: organic nanotube, lung, biodistribution, microparticle, particle shapeMaitani YNakamura YKon MSanada ESumiyoshi KFujine NAsakawa MKogiso MShimizu TDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 315-323 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Maitani Y Nakamura Y Kon M Sanada E Sumiyoshi K Fujine N Asakawa M Kogiso M Shimizu T Higher lung accumulation of intravenously injected organic nanotubes
description	Yoshie Maitani,1 Yuri Nakamura,1 Masao Kon,1 Emi Sanada,1 Kae Sumiyoshi,1 Natsuki Fujine,1 Masumi Asakawa,2 Masaki Kogiso,2 Toshimi Shimizu21Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan; 2Nanotube Research Center (NTRC), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, JapanAbstract: The size and shape of intravenously injected particles can affect their biodistribution and is of importance for the development of particulated drug carrier systems. In this study, organic nanotubes (ONTs) with a carboxyl group at the surface, a length of approximately 2 &micro;m and outer diameter of 70&ndash;90 nm, were injected intravenously into tumor-bearing mice. To use ONTs as drug carriers, the biodistribution in selected organs of ONTs postinjection was examined using irinotecan, as an entrapped water-soluble marker inside ONTs, and gadolinium-chelated ONT, as an ONT marker, and compared with that of a 3 &micro;m fluorescently labeled spherical microparticle which was similar size to the length of ONTs. It was found that for irinotecan, its active metabolite and gadolinium-chelated ONTs were highly accumulated in the lung, but to a lower level in the liver and spleen. On the other hand, microparticles deposited less in the lung and more highly in the liver. Moreover, histologic examination showed ONTs distributed more in lung tissues in part, whereas microparticles were present in blood vessels postinjection. These preliminary results support the notion of using negatively charged ONTs as intravascular carriers to maximize accumulation in the lung whilst reducing sequestration by the liver and spleen. This finding suggested that ONTs are potential carriers for lung-targeting drug delivery.Keywords: organic nanotube, lung, biodistribution, microparticle, particle shape
format	article
author	Maitani Y Nakamura Y Kon M Sanada E Sumiyoshi K Fujine N Asakawa M Kogiso M Shimizu T
author_facet	Maitani Y Nakamura Y Kon M Sanada E Sumiyoshi K Fujine N Asakawa M Kogiso M Shimizu T
author_sort	Maitani Y
title	Higher lung accumulation of intravenously injected organic nanotubes
title_short	Higher lung accumulation of intravenously injected organic nanotubes
title_full	Higher lung accumulation of intravenously injected organic nanotubes
title_fullStr	Higher lung accumulation of intravenously injected organic nanotubes
title_full_unstemmed	Higher lung accumulation of intravenously injected organic nanotubes
title_sort	higher lung accumulation of intravenously injected organic nanotubes
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/0e2aba36a2f244a8a4d4c80b4cd42104
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Higher lung accumulation of intravenously injected organic nanotubes

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