Differences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models.

The majority of olfaction studies focus on orthonasal stimulation where odors enter via the front nasal cavity, while retronasal olfaction, where odors enter the rear of the nasal cavity during feeding, is understudied. The coding of retronasal odors via coordinated spiking of neurons in the olfacto...

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Autores principales:	Michelle F Craft, Andrea K Barreiro, Shree Hari Gautam, Woodrow L Shew, Cheng Ly
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0e2ec483bc6947d681603c91807283b2
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spelling	oai:doaj.org-article:0e2ec483bc6947d681603c91807283b22021-12-02T19:57:45ZDifferences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models.1553-734X1553-735810.1371/journal.pcbi.1009169https://doaj.org/article/0e2ec483bc6947d681603c91807283b22021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009169https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358The majority of olfaction studies focus on orthonasal stimulation where odors enter via the front nasal cavity, while retronasal olfaction, where odors enter the rear of the nasal cavity during feeding, is understudied. The coding of retronasal odors via coordinated spiking of neurons in the olfactory bulb (OB) is largely unknown despite evidence that higher level processing is different than orthonasal. To this end, we use multi-electrode array in vivo recordings of rat OB mitral cells (MC) in response to a food odor with both modes of stimulation, and find significant differences in evoked firing rates and spike count covariances (i.e., noise correlations). Differences in spiking activity often have implications for sensory coding, thus we develop a single-compartment biophysical OB model that is able to reproduce key properties of important OB cell types. Prior experiments in olfactory receptor neurons (ORN) showed retro stimulation yields slower and spatially smaller ORN inputs than with ortho, yet whether this is consequential for OB activity remains unknown. Indeed with these specifications for ORN inputs, our OB model captures the salient trends in our OB data. We also analyze how first and second order ORN input statistics dynamically transfer to MC spiking statistics with a phenomenological linear-nonlinear filter model, and find that retro inputs result in larger linear filters than ortho inputs. Finally, our models show that the temporal profile of ORN is crucial for capturing our data and is thus a distinguishing feature between ortho and retro stimulation, even at the OB. Using data-driven modeling, we detail how ORN inputs result in differences in OB dynamics and MC spiking statistics. These differences may ultimately shape how ortho and retro odors are coded.Michelle F CraftAndrea K BarreiroShree Hari GautamWoodrow L ShewCheng LyPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 9, p e1009169 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Michelle F Craft Andrea K Barreiro Shree Hari Gautam Woodrow L Shew Cheng Ly Differences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models.
description	The majority of olfaction studies focus on orthonasal stimulation where odors enter via the front nasal cavity, while retronasal olfaction, where odors enter the rear of the nasal cavity during feeding, is understudied. The coding of retronasal odors via coordinated spiking of neurons in the olfactory bulb (OB) is largely unknown despite evidence that higher level processing is different than orthonasal. To this end, we use multi-electrode array in vivo recordings of rat OB mitral cells (MC) in response to a food odor with both modes of stimulation, and find significant differences in evoked firing rates and spike count covariances (i.e., noise correlations). Differences in spiking activity often have implications for sensory coding, thus we develop a single-compartment biophysical OB model that is able to reproduce key properties of important OB cell types. Prior experiments in olfactory receptor neurons (ORN) showed retro stimulation yields slower and spatially smaller ORN inputs than with ortho, yet whether this is consequential for OB activity remains unknown. Indeed with these specifications for ORN inputs, our OB model captures the salient trends in our OB data. We also analyze how first and second order ORN input statistics dynamically transfer to MC spiking statistics with a phenomenological linear-nonlinear filter model, and find that retro inputs result in larger linear filters than ortho inputs. Finally, our models show that the temporal profile of ORN is crucial for capturing our data and is thus a distinguishing feature between ortho and retro stimulation, even at the OB. Using data-driven modeling, we detail how ORN inputs result in differences in OB dynamics and MC spiking statistics. These differences may ultimately shape how ortho and retro odors are coded.
format	article
author	Michelle F Craft Andrea K Barreiro Shree Hari Gautam Woodrow L Shew Cheng Ly
author_facet	Michelle F Craft Andrea K Barreiro Shree Hari Gautam Woodrow L Shew Cheng Ly
author_sort	Michelle F Craft
title	Differences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models.
title_short	Differences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models.
title_full	Differences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models.
title_fullStr	Differences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models.
title_full_unstemmed	Differences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models.
title_sort	differences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0e2ec483bc6947d681603c91807283b2
work_keys_str_mv	AT michellefcraft differencesinolfactorybulbmitralcellspikingwithorthoandretronasalstimulationrevealedbydatadrivenmodels AT andreakbarreiro differencesinolfactorybulbmitralcellspikingwithorthoandretronasalstimulationrevealedbydatadrivenmodels AT shreeharigautam differencesinolfactorybulbmitralcellspikingwithorthoandretronasalstimulationrevealedbydatadrivenmodels AT woodrowlshew differencesinolfactorybulbmitralcellspikingwithorthoandretronasalstimulationrevealedbydatadrivenmodels AT chengly differencesinolfactorybulbmitralcellspikingwithorthoandretronasalstimulationrevealedbydatadrivenmodels
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Differences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models.

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