Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in <italic toggle="yes">Mycobacterium tuberculosis</italic>

ABSTRACT Indole propionic acid (IPA), produced by the gut microbiota, is active against Mycobacterium tuberculosis in vitro and in vivo. However, its mechanism of action is unknown. IPA is the deamination product of tryptophan (Trp) and thus a close structural analog of this essential aromatic amino...

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Autores principales: Dereje Abate Negatu, Yoshiyuki Yamada, Yu Xi, Mei Lin Go, Matthew Zimmerman, Uday Ganapathy, Véronique Dartois, Martin Gengenbacher, Thomas Dick
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
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NTM
Acceso en línea:https://doaj.org/article/0e2fba6e963346fe96944f4609ebe797
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