Quantitative evaluation of activity of thyroid-associated Ophthalmopathy using short-tau inversion recovery (STIR) sequence

Abstract Objective Quantitatively staging TAO using MRI remains limited. Our study aims to identify the cut-off signal intensity value for staging TAO using STIR sequence scan. Methods Between June 2018 and July 2020, a number of 51 patients with TAO (102 eyes) and 19 volunteer controls (38 eyes) we...

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Autores principales:	Qian Ge, Xiaohui Zhang, Lu Wang, Yao Fan, Qian Huang, Ning Yao, Jian Long, Chun Liu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Thyroid-associated ophthalmopathy Magnetic resonance imaging Extraocular muscle Short-tau inversion recovery Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/0e321c7e629d4859ac3a688dde27325f
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spelling	oai:doaj.org-article:0e321c7e629d4859ac3a688dde27325f2021-11-14T12:05:28ZQuantitative evaluation of activity of thyroid-associated Ophthalmopathy using short-tau inversion recovery (STIR) sequence10.1186/s12902-021-00895-31472-6823https://doaj.org/article/0e321c7e629d4859ac3a688dde27325f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12902-021-00895-3https://doaj.org/toc/1472-6823Abstract Objective Quantitatively staging TAO using MRI remains limited. Our study aims to identify the cut-off signal intensity value for staging TAO using STIR sequence scan. Methods Between June 2018 and July 2020, a number of 51 patients with TAO (102 eyes) and 19 volunteer controls (38 eyes) were recruited. The clinical and biochemical parameters were measured in each patient. Disease activity was diagnosed based on the Clinical Activity Score (CAS). The signal intensities of extraocular muscles were scanned using short-tau inversion recovery (STIR) sequences from MRI. Results Compared to the inactive TAO patients and the controls, the signal intensity ratios (SIRs) of the superior rectus, inferior rectus, medial rectus, lateral rectus on STIR images were significantly increased in the active TAO patients. After adjustment for age and smokers, the SIRs of four extraocular muscles showed strong associations with CAS. By receiver operator characteristic (ROC) curve analysis, all four muscle SIRs demonstrated good efficiency for predicting disease activity [area under curve (AUC) 0.75–0.83, all P < 0.01]. The identified cut-off SIR values were further validated in a new group of TAO patients (30 eyes) enrolled between September 2020 and January 2021. The cut-off SIR value of > 2.9 in the inferior rectus showed optimal diagnostic value for staging the active TAO. Conclusions the signal intensity of extraocular muscles on STIR sequence was a good predictor for TAO activity. A cut-off SIR value of > 2.9 in the inferior rectus could be applied to evaluate the active stage of TAO.Qian GeXiaohui ZhangLu WangYao FanQian HuangNing YaoJian LongChun LiuBMCarticleThyroid-associated ophthalmopathyMagnetic resonance imagingExtraocular muscleShort-tau inversion recoveryDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENBMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Thyroid-associated ophthalmopathy Magnetic resonance imaging Extraocular muscle Short-tau inversion recovery Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Thyroid-associated ophthalmopathy Magnetic resonance imaging Extraocular muscle Short-tau inversion recovery Diseases of the endocrine glands. Clinical endocrinology RC648-665 Qian Ge Xiaohui Zhang Lu Wang Yao Fan Qian Huang Ning Yao Jian Long Chun Liu Quantitative evaluation of activity of thyroid-associated Ophthalmopathy using short-tau inversion recovery (STIR) sequence
description	Abstract Objective Quantitatively staging TAO using MRI remains limited. Our study aims to identify the cut-off signal intensity value for staging TAO using STIR sequence scan. Methods Between June 2018 and July 2020, a number of 51 patients with TAO (102 eyes) and 19 volunteer controls (38 eyes) were recruited. The clinical and biochemical parameters were measured in each patient. Disease activity was diagnosed based on the Clinical Activity Score (CAS). The signal intensities of extraocular muscles were scanned using short-tau inversion recovery (STIR) sequences from MRI. Results Compared to the inactive TAO patients and the controls, the signal intensity ratios (SIRs) of the superior rectus, inferior rectus, medial rectus, lateral rectus on STIR images were significantly increased in the active TAO patients. After adjustment for age and smokers, the SIRs of four extraocular muscles showed strong associations with CAS. By receiver operator characteristic (ROC) curve analysis, all four muscle SIRs demonstrated good efficiency for predicting disease activity [area under curve (AUC) 0.75–0.83, all P < 0.01]. The identified cut-off SIR values were further validated in a new group of TAO patients (30 eyes) enrolled between September 2020 and January 2021. The cut-off SIR value of > 2.9 in the inferior rectus showed optimal diagnostic value for staging the active TAO. Conclusions the signal intensity of extraocular muscles on STIR sequence was a good predictor for TAO activity. A cut-off SIR value of > 2.9 in the inferior rectus could be applied to evaluate the active stage of TAO.
format	article
author	Qian Ge Xiaohui Zhang Lu Wang Yao Fan Qian Huang Ning Yao Jian Long Chun Liu
author_facet	Qian Ge Xiaohui Zhang Lu Wang Yao Fan Qian Huang Ning Yao Jian Long Chun Liu
author_sort	Qian Ge
title	Quantitative evaluation of activity of thyroid-associated Ophthalmopathy using short-tau inversion recovery (STIR) sequence
title_short	Quantitative evaluation of activity of thyroid-associated Ophthalmopathy using short-tau inversion recovery (STIR) sequence
title_full	Quantitative evaluation of activity of thyroid-associated Ophthalmopathy using short-tau inversion recovery (STIR) sequence
title_fullStr	Quantitative evaluation of activity of thyroid-associated Ophthalmopathy using short-tau inversion recovery (STIR) sequence
title_full_unstemmed	Quantitative evaluation of activity of thyroid-associated Ophthalmopathy using short-tau inversion recovery (STIR) sequence
title_sort	quantitative evaluation of activity of thyroid-associated ophthalmopathy using short-tau inversion recovery (stir) sequence
publisher	BMC
publishDate	2021
url	https://doaj.org/article/0e321c7e629d4859ac3a688dde27325f
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Quantitative evaluation of activity of thyroid-associated Ophthalmopathy using short-tau inversion recovery (STIR) sequence

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