Pericyte-targeting drug delivery and tissue engineering

Eunah Kang,1 Jong Wook Shin2 1School of Chemical Engineering and Material Science, 2Division of Allergic and Pulmonary Medicine, Department of Internal Medicine, College of Medicine, Chung-Ang University, Dongjak-Gu, Seoul, South Korea Abstract: Pericytes are contractile mural cells that wrap arou...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kang E, Shin JW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	pericytes pericyte-targeting drug delivery tissue engineering platelet-derived growth factor angiogenesis and vascular remodeling Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0e32ddddf54646639e38a5c210542159
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0e32ddddf54646639e38a5c210542159
record_format	dspace
spelling	oai:doaj.org-article:0e32ddddf54646639e38a5c2105421592021-12-02T07:15:14ZPericyte-targeting drug delivery and tissue engineering1178-2013https://doaj.org/article/0e32ddddf54646639e38a5c2105421592016-05-01T00:00:00Zhttps://www.dovepress.com/pericyte-targeting-drug-delivery-and-tissue-engineering-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Eunah Kang,1 Jong Wook Shin2 1School of Chemical Engineering and Material Science, 2Division of Allergic and Pulmonary Medicine, Department of Internal Medicine, College of Medicine, Chung-Ang University, Dongjak-Gu, Seoul, South Korea Abstract: Pericytes are contractile mural cells that wrap around the endothelial cells of capillaries and venules. Depending on the triggers by cellular signals, pericytes have specific functionality in tumor microenvironments, properties of potent stem cells, and plasticity in cellular pathology. These features of pericytes can be activated for the promotion or reduction of angiogenesis. Frontier studies have exploited pericyte-targeting drug delivery, using pericyte-specific peptides, small molecules, and DNA in tumor therapy. Moreover, the communication between pericytes and endothelial cells has been applied to the induction of vessel neoformation in tissue engineering. Pericytes may prove to be a novel target for tumor therapy and tissue engineering. The present paper specifically reviews pericyte-specific drug delivery and tissue engineering, allowing insight into the emerging research targeting pericytes. Keywords: pericytes, pericyte-targeting drug delivery, tissue engineering, platelet-derived growth factor, angiogenesis, vascular remodelingKang EShin JWDove Medical Pressarticlepericytespericyte-targeting drug deliverytissue engineeringplatelet-derived growth factorangiogenesisand vascular remodelingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2397-2406 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	pericytes pericyte-targeting drug delivery tissue engineering platelet-derived growth factor angiogenesis and vascular remodeling Medicine (General) R5-920
spellingShingle	pericytes pericyte-targeting drug delivery tissue engineering platelet-derived growth factor angiogenesis and vascular remodeling Medicine (General) R5-920 Kang E Shin JW Pericyte-targeting drug delivery and tissue engineering
description	Eunah Kang,1 Jong Wook Shin2 1School of Chemical Engineering and Material Science, 2Division of Allergic and Pulmonary Medicine, Department of Internal Medicine, College of Medicine, Chung-Ang University, Dongjak-Gu, Seoul, South Korea Abstract: Pericytes are contractile mural cells that wrap around the endothelial cells of capillaries and venules. Depending on the triggers by cellular signals, pericytes have specific functionality in tumor microenvironments, properties of potent stem cells, and plasticity in cellular pathology. These features of pericytes can be activated for the promotion or reduction of angiogenesis. Frontier studies have exploited pericyte-targeting drug delivery, using pericyte-specific peptides, small molecules, and DNA in tumor therapy. Moreover, the communication between pericytes and endothelial cells has been applied to the induction of vessel neoformation in tissue engineering. Pericytes may prove to be a novel target for tumor therapy and tissue engineering. The present paper specifically reviews pericyte-specific drug delivery and tissue engineering, allowing insight into the emerging research targeting pericytes. Keywords: pericytes, pericyte-targeting drug delivery, tissue engineering, platelet-derived growth factor, angiogenesis, vascular remodeling
format	article
author	Kang E Shin JW
author_facet	Kang E Shin JW
author_sort	Kang E
title	Pericyte-targeting drug delivery and tissue engineering
title_short	Pericyte-targeting drug delivery and tissue engineering
title_full	Pericyte-targeting drug delivery and tissue engineering
title_fullStr	Pericyte-targeting drug delivery and tissue engineering
title_full_unstemmed	Pericyte-targeting drug delivery and tissue engineering
title_sort	pericyte-targeting drug delivery and tissue engineering
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/0e32ddddf54646639e38a5c210542159
work_keys_str_mv	AT kange pericytetargetingdrugdeliveryandtissueengineering AT shinjw pericytetargetingdrugdeliveryandtissueengineering
_version_	1718399500577406976

Pericyte-targeting drug delivery and tissue engineering

Ejemplares similares