Mirror symmetric bimanual movement priming can increase corticomotor excitability and enhance motor learning.

Repetitive mirror symmetric bilateral upper limb may be a suitable priming technique for upper limb rehabilitation after stroke. Here we demonstrate neurophysiological and behavioural after-effects in healthy participants after priming with 20 minutes of repetitive active-passive bimanual wrist flex...

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Autores principales:	Winston D Byblow, Cathy M Stinear, Marie-Claire Smith, Lotte Bjerre, Brian K Flaskager, Alana B McCambridge
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0e374f6626174e5fa7e2fe8972a1b0aa
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spelling	oai:doaj.org-article:0e374f6626174e5fa7e2fe8972a1b0aa2021-11-18T07:24:27ZMirror symmetric bimanual movement priming can increase corticomotor excitability and enhance motor learning.1932-620310.1371/journal.pone.0033882https://doaj.org/article/0e374f6626174e5fa7e2fe8972a1b0aa2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22457799/?tool=EBIhttps://doaj.org/toc/1932-6203Repetitive mirror symmetric bilateral upper limb may be a suitable priming technique for upper limb rehabilitation after stroke. Here we demonstrate neurophysiological and behavioural after-effects in healthy participants after priming with 20 minutes of repetitive active-passive bimanual wrist flexion and extension in a mirror symmetric pattern with respect to the body midline (MIR) compared to an control priming condition with alternating flexion-extension (ALT). Transcranial magnetic stimulation (TMS) indicated that corticomotor excitability (CME) of the passive hemisphere remained elevated compared to baseline for at least 30 minutes after MIR but not ALT, evidenced by an increase in the size of motor evoked potentials in ECR and FCR. Short and long-latency intracortical inhibition (SICI, LICI), short afferent inhibition (SAI) and interhemispheric inhibition (IHI) were also examined using pairs of stimuli. LICI differed between patterns, with less LICI after MIR compared with ALT, and an effect of pattern on IHI, with reduced IHI in passive FCR 15 minutes after MIR compared with ALT and baseline. There was no effect of pattern on SAI or FCR H-reflex. Similarly, SICI remained unchanged after 20 minutes of MIR. We then had participants complete a timed manual dexterity motor learning task with the passive hand during, immediately after, and 24 hours after MIR or control priming. The rate of task completion was faster with MIR priming compared to control conditions. Finally, ECR and FCR MEPs were examined within a pre-movement facilitation paradigm of wrist extension before and after MIR. ECR, but not FCR, MEPs were consistently facilitated before and after MIR, demonstrating no degradation of selective muscle activation. In summary, mirror symmetric active-passive bimanual movement increases CME and can enhance motor learning without degradation of muscle selectivity. These findings rationalise the use of mirror symmetric bimanual movement as a priming modality in post-stroke upper limb rehabilitation.Winston D ByblowCathy M StinearMarie-Claire SmithLotte BjerreBrian K FlaskagerAlana B McCambridgePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e33882 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Winston D Byblow Cathy M Stinear Marie-Claire Smith Lotte Bjerre Brian K Flaskager Alana B McCambridge Mirror symmetric bimanual movement priming can increase corticomotor excitability and enhance motor learning.
description	Repetitive mirror symmetric bilateral upper limb may be a suitable priming technique for upper limb rehabilitation after stroke. Here we demonstrate neurophysiological and behavioural after-effects in healthy participants after priming with 20 minutes of repetitive active-passive bimanual wrist flexion and extension in a mirror symmetric pattern with respect to the body midline (MIR) compared to an control priming condition with alternating flexion-extension (ALT). Transcranial magnetic stimulation (TMS) indicated that corticomotor excitability (CME) of the passive hemisphere remained elevated compared to baseline for at least 30 minutes after MIR but not ALT, evidenced by an increase in the size of motor evoked potentials in ECR and FCR. Short and long-latency intracortical inhibition (SICI, LICI), short afferent inhibition (SAI) and interhemispheric inhibition (IHI) were also examined using pairs of stimuli. LICI differed between patterns, with less LICI after MIR compared with ALT, and an effect of pattern on IHI, with reduced IHI in passive FCR 15 minutes after MIR compared with ALT and baseline. There was no effect of pattern on SAI or FCR H-reflex. Similarly, SICI remained unchanged after 20 minutes of MIR. We then had participants complete a timed manual dexterity motor learning task with the passive hand during, immediately after, and 24 hours after MIR or control priming. The rate of task completion was faster with MIR priming compared to control conditions. Finally, ECR and FCR MEPs were examined within a pre-movement facilitation paradigm of wrist extension before and after MIR. ECR, but not FCR, MEPs were consistently facilitated before and after MIR, demonstrating no degradation of selective muscle activation. In summary, mirror symmetric active-passive bimanual movement increases CME and can enhance motor learning without degradation of muscle selectivity. These findings rationalise the use of mirror symmetric bimanual movement as a priming modality in post-stroke upper limb rehabilitation.
format	article
author	Winston D Byblow Cathy M Stinear Marie-Claire Smith Lotte Bjerre Brian K Flaskager Alana B McCambridge
author_facet	Winston D Byblow Cathy M Stinear Marie-Claire Smith Lotte Bjerre Brian K Flaskager Alana B McCambridge
author_sort	Winston D Byblow
title	Mirror symmetric bimanual movement priming can increase corticomotor excitability and enhance motor learning.
title_short	Mirror symmetric bimanual movement priming can increase corticomotor excitability and enhance motor learning.
title_full	Mirror symmetric bimanual movement priming can increase corticomotor excitability and enhance motor learning.
title_fullStr	Mirror symmetric bimanual movement priming can increase corticomotor excitability and enhance motor learning.
title_full_unstemmed	Mirror symmetric bimanual movement priming can increase corticomotor excitability and enhance motor learning.
title_sort	mirror symmetric bimanual movement priming can increase corticomotor excitability and enhance motor learning.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0e374f6626174e5fa7e2fe8972a1b0aa
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Mirror symmetric bimanual movement priming can increase corticomotor excitability and enhance motor learning.

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