Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

Previous genome-wide association studies have identified risk loci for pancreatic cancer but were centered on individuals of European ancestry. Here the authors identify GP2 gene variants associated with pancreatic cancer susceptibility in populations of East Asian ancestry.

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Autores principales:	Yingsong Lin, Masahiro Nakatochi, Yasuyuki Hosono, Hidemi Ito, Yoichiro Kamatani, Akihito Inoko, Hiromi Sakamoto, Fumie Kinoshita, Yumiko Kobayashi, Hiroshi Ishii, Masato Ozaka, Takashi Sasaki, Masato Matsuyama, Naoki Sasahira, Manabu Morimoto, Satoshi Kobayashi, Taito Fukushima, Makoto Ueno, Shinichi Ohkawa, Naoto Egawa, Sawako Kuruma, Mitsuru Mori, Haruhisa Nakao, Yasushi Adachi, Masumi Okuda, Takako Osaki, Shigeru Kamiya, Chaochen Wang, Kazuo Hara, Yasuhiro Shimizu, Tatsuo Miyamoto, Yuko Hayashi, Hiromichi Ebi, Tomohiro Kohmoto, Issei Imoto, Yumiko Kasugai, Yoshinori Murakami, Masato Akiyama, Kazuyoshi Ishigaki, Koichi Matsuda, Makoto Hirata, Kazuaki Shimada, Takuji Okusaka, Takahisa Kawaguchi, Meiko Takahashi, Yoshiyuki Watanabe, Kiyonori Kuriki, Aya Kadota, Rieko Okada, Haruo Mikami, Toshiro Takezaki, Sadao Suzuki, Taiki Yamaji, Motoki Iwasaki, Norie Sawada, Atsushi Goto, Kengo Kinoshita, Nobuo Fuse, Fumiki Katsuoka, Atsushi Shimizu, Satoshi S. Nishizuka, Kozo Tanno, Ken Suzuki, Yukinori Okada, Momoko Horikoshi, Toshimasa Yamauchi, Takashi Kadowaki, Herbert Yu, Jun Zhong, Laufey T. Amundadottir, Yuichiro Doki, Hideshi Ishii, Hidetoshi Eguchi, David Bogumil, Christopher A. Haiman, Loic Le Marchand, Masaki Mori, Harvey Risch, Veronica W. Setiawan, Shoichiro Tsugane, Kenji Wakai, Teruhiko Yoshida, Fumihiko Matsuda, Michiaki Kubo, Shogo Kikuchi, Keitaro Matsuo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e3ece4078314ff691b9afbec5ed4300
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spelling	oai:doaj.org-article:0e3ece4078314ff691b9afbec5ed43002021-12-02T18:02:51ZGenome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer10.1038/s41467-020-16711-w2041-1723https://doaj.org/article/0e3ece4078314ff691b9afbec5ed43002020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16711-whttps://doaj.org/toc/2041-1723Previous genome-wide association studies have identified risk loci for pancreatic cancer but were centered on individuals of European ancestry. Here the authors identify GP2 gene variants associated with pancreatic cancer susceptibility in populations of East Asian ancestry.Yingsong LinMasahiro NakatochiYasuyuki HosonoHidemi ItoYoichiro KamataniAkihito InokoHiromi SakamotoFumie KinoshitaYumiko KobayashiHiroshi IshiiMasato OzakaTakashi SasakiMasato MatsuyamaNaoki SasahiraManabu MorimotoSatoshi KobayashiTaito FukushimaMakoto UenoShinichi OhkawaNaoto EgawaSawako KurumaMitsuru MoriHaruhisa NakaoYasushi AdachiMasumi OkudaTakako OsakiShigeru KamiyaChaochen WangKazuo HaraYasuhiro ShimizuTatsuo MiyamotoYuko HayashiHiromichi EbiTomohiro KohmotoIssei ImotoYumiko KasugaiYoshinori MurakamiMasato AkiyamaKazuyoshi IshigakiKoichi MatsudaMakoto HirataKazuaki ShimadaTakuji OkusakaTakahisa KawaguchiMeiko TakahashiYoshiyuki WatanabeKiyonori KurikiAya KadotaRieko OkadaHaruo MikamiToshiro TakezakiSadao SuzukiTaiki YamajiMotoki IwasakiNorie SawadaAtsushi GotoKengo KinoshitaNobuo FuseFumiki KatsuokaAtsushi ShimizuSatoshi S. NishizukaKozo TannoKen SuzukiYukinori OkadaMomoko HorikoshiToshimasa YamauchiTakashi KadowakiHerbert YuJun ZhongLaufey T. AmundadottirYuichiro DokiHideshi IshiiHidetoshi EguchiDavid BogumilChristopher A. HaimanLoic Le MarchandMasaki MoriHarvey RischVeronica W. SetiawanShoichiro TsuganeKenji WakaiTeruhiko YoshidaFumihiko MatsudaMichiaki KuboShogo KikuchiKeitaro MatsuoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yingsong Lin Masahiro Nakatochi Yasuyuki Hosono Hidemi Ito Yoichiro Kamatani Akihito Inoko Hiromi Sakamoto Fumie Kinoshita Yumiko Kobayashi Hiroshi Ishii Masato Ozaka Takashi Sasaki Masato Matsuyama Naoki Sasahira Manabu Morimoto Satoshi Kobayashi Taito Fukushima Makoto Ueno Shinichi Ohkawa Naoto Egawa Sawako Kuruma Mitsuru Mori Haruhisa Nakao Yasushi Adachi Masumi Okuda Takako Osaki Shigeru Kamiya Chaochen Wang Kazuo Hara Yasuhiro Shimizu Tatsuo Miyamoto Yuko Hayashi Hiromichi Ebi Tomohiro Kohmoto Issei Imoto Yumiko Kasugai Yoshinori Murakami Masato Akiyama Kazuyoshi Ishigaki Koichi Matsuda Makoto Hirata Kazuaki Shimada Takuji Okusaka Takahisa Kawaguchi Meiko Takahashi Yoshiyuki Watanabe Kiyonori Kuriki Aya Kadota Rieko Okada Haruo Mikami Toshiro Takezaki Sadao Suzuki Taiki Yamaji Motoki Iwasaki Norie Sawada Atsushi Goto Kengo Kinoshita Nobuo Fuse Fumiki Katsuoka Atsushi Shimizu Satoshi S. Nishizuka Kozo Tanno Ken Suzuki Yukinori Okada Momoko Horikoshi Toshimasa Yamauchi Takashi Kadowaki Herbert Yu Jun Zhong Laufey T. Amundadottir Yuichiro Doki Hideshi Ishii Hidetoshi Eguchi David Bogumil Christopher A. Haiman Loic Le Marchand Masaki Mori Harvey Risch Veronica W. Setiawan Shoichiro Tsugane Kenji Wakai Teruhiko Yoshida Fumihiko Matsuda Michiaki Kubo Shogo Kikuchi Keitaro Matsuo Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer
description	Previous genome-wide association studies have identified risk loci for pancreatic cancer but were centered on individuals of European ancestry. Here the authors identify GP2 gene variants associated with pancreatic cancer susceptibility in populations of East Asian ancestry.
format	article
author	Yingsong Lin Masahiro Nakatochi Yasuyuki Hosono Hidemi Ito Yoichiro Kamatani Akihito Inoko Hiromi Sakamoto Fumie Kinoshita Yumiko Kobayashi Hiroshi Ishii Masato Ozaka Takashi Sasaki Masato Matsuyama Naoki Sasahira Manabu Morimoto Satoshi Kobayashi Taito Fukushima Makoto Ueno Shinichi Ohkawa Naoto Egawa Sawako Kuruma Mitsuru Mori Haruhisa Nakao Yasushi Adachi Masumi Okuda Takako Osaki Shigeru Kamiya Chaochen Wang Kazuo Hara Yasuhiro Shimizu Tatsuo Miyamoto Yuko Hayashi Hiromichi Ebi Tomohiro Kohmoto Issei Imoto Yumiko Kasugai Yoshinori Murakami Masato Akiyama Kazuyoshi Ishigaki Koichi Matsuda Makoto Hirata Kazuaki Shimada Takuji Okusaka Takahisa Kawaguchi Meiko Takahashi Yoshiyuki Watanabe Kiyonori Kuriki Aya Kadota Rieko Okada Haruo Mikami Toshiro Takezaki Sadao Suzuki Taiki Yamaji Motoki Iwasaki Norie Sawada Atsushi Goto Kengo Kinoshita Nobuo Fuse Fumiki Katsuoka Atsushi Shimizu Satoshi S. Nishizuka Kozo Tanno Ken Suzuki Yukinori Okada Momoko Horikoshi Toshimasa Yamauchi Takashi Kadowaki Herbert Yu Jun Zhong Laufey T. Amundadottir Yuichiro Doki Hideshi Ishii Hidetoshi Eguchi David Bogumil Christopher A. Haiman Loic Le Marchand Masaki Mori Harvey Risch Veronica W. Setiawan Shoichiro Tsugane Kenji Wakai Teruhiko Yoshida Fumihiko Matsuda Michiaki Kubo Shogo Kikuchi Keitaro Matsuo
author_facet	Yingsong Lin Masahiro Nakatochi Yasuyuki Hosono Hidemi Ito Yoichiro Kamatani Akihito Inoko Hiromi Sakamoto Fumie Kinoshita Yumiko Kobayashi Hiroshi Ishii Masato Ozaka Takashi Sasaki Masato Matsuyama Naoki Sasahira Manabu Morimoto Satoshi Kobayashi Taito Fukushima Makoto Ueno Shinichi Ohkawa Naoto Egawa Sawako Kuruma Mitsuru Mori Haruhisa Nakao Yasushi Adachi Masumi Okuda Takako Osaki Shigeru Kamiya Chaochen Wang Kazuo Hara Yasuhiro Shimizu Tatsuo Miyamoto Yuko Hayashi Hiromichi Ebi Tomohiro Kohmoto Issei Imoto Yumiko Kasugai Yoshinori Murakami Masato Akiyama Kazuyoshi Ishigaki Koichi Matsuda Makoto Hirata Kazuaki Shimada Takuji Okusaka Takahisa Kawaguchi Meiko Takahashi Yoshiyuki Watanabe Kiyonori Kuriki Aya Kadota Rieko Okada Haruo Mikami Toshiro Takezaki Sadao Suzuki Taiki Yamaji Motoki Iwasaki Norie Sawada Atsushi Goto Kengo Kinoshita Nobuo Fuse Fumiki Katsuoka Atsushi Shimizu Satoshi S. Nishizuka Kozo Tanno Ken Suzuki Yukinori Okada Momoko Horikoshi Toshimasa Yamauchi Takashi Kadowaki Herbert Yu Jun Zhong Laufey T. Amundadottir Yuichiro Doki Hideshi Ishii Hidetoshi Eguchi David Bogumil Christopher A. Haiman Loic Le Marchand Masaki Mori Harvey Risch Veronica W. Setiawan Shoichiro Tsugane Kenji Wakai Teruhiko Yoshida Fumihiko Matsuda Michiaki Kubo Shogo Kikuchi Keitaro Matsuo
author_sort	Yingsong Lin
title	Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer
title_short	Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer
title_full	Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer
title_fullStr	Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer
title_full_unstemmed	Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer
title_sort	genome-wide association meta-analysis identifies gp2 gene risk variants for pancreatic cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0e3ece4078314ff691b9afbec5ed4300
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Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

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