Identification of candidate genes for devil facial tumour disease tumourigenesis

Abstract Devil facial tumour (DFT) disease, a transmissible cancer where the infectious agent is the tumour itself, has caused a dramatic decrease in Tasmanian devil numbers in the wild. The purpose of this study was to take a candidate gene/pathway approach to identify potentially perturbed genes o...

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Autores principales:	Robyn L. Taylor, Yiru Zhang, Jennifer P. Schöning, Janine E. Deakin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0e3f71ccfc644b20afbce9265442a116
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spelling	oai:doaj.org-article:0e3f71ccfc644b20afbce9265442a1162021-12-02T11:52:43ZIdentification of candidate genes for devil facial tumour disease tumourigenesis10.1038/s41598-017-08908-92045-2322https://doaj.org/article/0e3f71ccfc644b20afbce9265442a1162017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08908-9https://doaj.org/toc/2045-2322Abstract Devil facial tumour (DFT) disease, a transmissible cancer where the infectious agent is the tumour itself, has caused a dramatic decrease in Tasmanian devil numbers in the wild. The purpose of this study was to take a candidate gene/pathway approach to identify potentially perturbed genes or pathways in DFT. A fusion of chromosome 1 and X is posited as the initial event leading to the development of DFT, with the rearranged chromosome 1 material now stably maintained as the tumour spreads through the population. This hypothesis makes chromosome 1 a prime chromosome on which to search for mutations involved in tumourigenesis. As DFT1 has a Schwann cell origin, we selected genes commonly implicated in tumour pathways in human nerve cancers, or cancers more generally, to determine whether they were rearranged in DFT1, and mapped them using molecular cytogenetics. Many cancer-related genes were rearranged, such as the region containing the tumour suppressor NF2 and a copy gain for ERBB3, a member of the epidermal growth factor receptor family of receptor tyrosine kinases implicated in proliferation and invasion of tumours in humans. Our mapping results have provided strong candidates not previously detected by sequencing DFT1 genomes.Robyn L. TaylorYiru ZhangJennifer P. SchöningJanine E. DeakinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Robyn L. Taylor Yiru Zhang Jennifer P. Schöning Janine E. Deakin Identification of candidate genes for devil facial tumour disease tumourigenesis
description	Abstract Devil facial tumour (DFT) disease, a transmissible cancer where the infectious agent is the tumour itself, has caused a dramatic decrease in Tasmanian devil numbers in the wild. The purpose of this study was to take a candidate gene/pathway approach to identify potentially perturbed genes or pathways in DFT. A fusion of chromosome 1 and X is posited as the initial event leading to the development of DFT, with the rearranged chromosome 1 material now stably maintained as the tumour spreads through the population. This hypothesis makes chromosome 1 a prime chromosome on which to search for mutations involved in tumourigenesis. As DFT1 has a Schwann cell origin, we selected genes commonly implicated in tumour pathways in human nerve cancers, or cancers more generally, to determine whether they were rearranged in DFT1, and mapped them using molecular cytogenetics. Many cancer-related genes were rearranged, such as the region containing the tumour suppressor NF2 and a copy gain for ERBB3, a member of the epidermal growth factor receptor family of receptor tyrosine kinases implicated in proliferation and invasion of tumours in humans. Our mapping results have provided strong candidates not previously detected by sequencing DFT1 genomes.
format	article
author	Robyn L. Taylor Yiru Zhang Jennifer P. Schöning Janine E. Deakin
author_facet	Robyn L. Taylor Yiru Zhang Jennifer P. Schöning Janine E. Deakin
author_sort	Robyn L. Taylor
title	Identification of candidate genes for devil facial tumour disease tumourigenesis
title_short	Identification of candidate genes for devil facial tumour disease tumourigenesis
title_full	Identification of candidate genes for devil facial tumour disease tumourigenesis
title_fullStr	Identification of candidate genes for devil facial tumour disease tumourigenesis
title_full_unstemmed	Identification of candidate genes for devil facial tumour disease tumourigenesis
title_sort	identification of candidate genes for devil facial tumour disease tumourigenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0e3f71ccfc644b20afbce9265442a116
work_keys_str_mv	AT robynltaylor identificationofcandidategenesfordevilfacialtumourdiseasetumourigenesis AT yiruzhang identificationofcandidategenesfordevilfacialtumourdiseasetumourigenesis AT jenniferpschoning identificationofcandidategenesfordevilfacialtumourdiseasetumourigenesis AT janineedeakin identificationofcandidategenesfordevilfacialtumourdiseasetumourigenesis
_version_	1718394907685552128

Identification of candidate genes for devil facial tumour disease tumourigenesis

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