Chromosome arm aneuploidies shape tumour evolution and drug response

Chromosome arm aneuploidies shape tumour evolution and drug response

Chromosome arm-level aneuploidies (CAAs) are frequently observed in cancer. Here, the authors analyse CAA landscapes across different tumour types, relating these chromosome arm gains and losses to tumour evolution, metastasis, patient survival and response to a range of anti-cancer therapies.

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Autores principales: Ankit Shukla, Thu H. M. Nguyen, Sarat B. Moka, Jonathan J. Ellis, John P. Grady, Harald Oey, Alexandre S. Cristino, Kum Kum Khanna, Dirk P. Kroese, Lutz Krause, Eloise Dray, J. Lynn Fink, Pascal H. G. Duijf
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/0e49d0a39fa34863b24fe89eadb7f3d8
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spelling oai:doaj.org-article:0e49d0a39fa34863b24fe89eadb7f3d82021-12-02T15:37:15ZChromosome arm aneuploidies shape tumour evolution and drug response10.1038/s41467-020-14286-02041-1723https://doaj.org/article/0e49d0a39fa34863b24fe89eadb7f3d82020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14286-0https://doaj.org/toc/2041-1723Chromosome arm-level aneuploidies (CAAs) are frequently observed in cancer. Here, the authors analyse CAA landscapes across different tumour types, relating these chromosome arm gains and losses to tumour evolution, metastasis, patient survival and response to a range of anti-cancer therapies.Ankit ShuklaThu H. M. NguyenSarat B. MokaJonathan J. EllisJohn P. GradyHarald OeyAlexandre S. CristinoKum Kum KhannaDirk P. KroeseLutz KrauseEloise DrayJ. Lynn FinkPascal H. G. DuijfNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ankit Shukla
Thu H. M. Nguyen
Sarat B. Moka
Jonathan J. Ellis
John P. Grady
Harald Oey
Alexandre S. Cristino
Kum Kum Khanna
Dirk P. Kroese
Lutz Krause
Eloise Dray
J. Lynn Fink
Pascal H. G. Duijf
Chromosome arm aneuploidies shape tumour evolution and drug response
description Chromosome arm-level aneuploidies (CAAs) are frequently observed in cancer. Here, the authors analyse CAA landscapes across different tumour types, relating these chromosome arm gains and losses to tumour evolution, metastasis, patient survival and response to a range of anti-cancer therapies.
format article
author Ankit Shukla
Thu H. M. Nguyen
Sarat B. Moka
Jonathan J. Ellis
John P. Grady
Harald Oey
Alexandre S. Cristino
Kum Kum Khanna
Dirk P. Kroese
Lutz Krause
Eloise Dray
J. Lynn Fink
Pascal H. G. Duijf
author_facet Ankit Shukla
Thu H. M. Nguyen
Sarat B. Moka
Jonathan J. Ellis
John P. Grady
Harald Oey
Alexandre S. Cristino
Kum Kum Khanna
Dirk P. Kroese
Lutz Krause
Eloise Dray
J. Lynn Fink
Pascal H. G. Duijf
author_sort Ankit Shukla
title Chromosome arm aneuploidies shape tumour evolution and drug response
title_short Chromosome arm aneuploidies shape tumour evolution and drug response
title_full Chromosome arm aneuploidies shape tumour evolution and drug response
title_fullStr Chromosome arm aneuploidies shape tumour evolution and drug response
title_full_unstemmed Chromosome arm aneuploidies shape tumour evolution and drug response
title_sort chromosome arm aneuploidies shape tumour evolution and drug response
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/0e49d0a39fa34863b24fe89eadb7f3d8
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