Comprehensive literature review on COVID-19 vaccines and role of SARS-CoV-2 variants in the pandemic

Since the outbreak of the COVID-19 pandemic, there has been a rapid expansion in vaccine research focusing on exploiting the novel discoveries on the pathophysiology, genomics, and molecular biology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although the current p...

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Autores principales:	Charles Yap, Abulhassan Ali, Amogh Prabhakar, Akul Prabhakar, Aman Pal, Ying Yi Lim, Pramath Kakodkar
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Therapeutics. Pharmacology RM1-950 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/0e4d001fcbf7468aac67f37b064bf789
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spelling	oai:doaj.org-article:0e4d001fcbf7468aac67f37b064bf7892021-11-30T23:34:14ZComprehensive literature review on COVID-19 vaccines and role of SARS-CoV-2 variants in the pandemic2515-136310.1177/25151355211059791https://doaj.org/article/0e4d001fcbf7468aac67f37b064bf7892021-11-01T00:00:00Zhttps://doi.org/10.1177/25151355211059791https://doaj.org/toc/2515-1363Since the outbreak of the COVID-19 pandemic, there has been a rapid expansion in vaccine research focusing on exploiting the novel discoveries on the pathophysiology, genomics, and molecular biology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although the current preventive measures are primarily socially distancing by maintaining a 1 m distance, it is supplemented using facial masks and other personal hygiene measures. However, the induction of vaccines as primary prevention is crucial to eradicating the disease to attempt restoration to normalcy. This literature review aims to describe the physiology of the vaccines and how the spike protein is used as a target to elicit an antibody-dependent immune response in humans. Furthermore, the overview, dosing strategies, efficacy, and side effects will be discussed for the notable vaccines: BioNTech/Pfizer, Moderna, AstraZeneca, Janssen, Gamaleya, and SinoVac. In addition, the development of other prominent COVID-19 vaccines will be highlighted alongside the sustainability of the vaccine-mediated immune response and current contraindications. As the research is rapidly expanding, we have looked at the association between pregnancy and COVID-19 vaccinations, in addition to the current reviews on the mixing of vaccines. Finally, the prominent emerging variants of concern are described, and the efficacy of the notable vaccines toward these variants has been summarized.Charles YapAbulhassan AliAmogh PrabhakarAkul PrabhakarAman PalYing Yi LimPramath KakodkarSAGE PublishingarticleTherapeutics. PharmacologyRM1-950Immunologic diseases. AllergyRC581-607ENTherapeutic Advances in Vaccines and Immunotherapy, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950 Immunologic diseases. Allergy RC581-607
spellingShingle	Therapeutics. Pharmacology RM1-950 Immunologic diseases. Allergy RC581-607 Charles Yap Abulhassan Ali Amogh Prabhakar Akul Prabhakar Aman Pal Ying Yi Lim Pramath Kakodkar Comprehensive literature review on COVID-19 vaccines and role of SARS-CoV-2 variants in the pandemic
description	Since the outbreak of the COVID-19 pandemic, there has been a rapid expansion in vaccine research focusing on exploiting the novel discoveries on the pathophysiology, genomics, and molecular biology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although the current preventive measures are primarily socially distancing by maintaining a 1 m distance, it is supplemented using facial masks and other personal hygiene measures. However, the induction of vaccines as primary prevention is crucial to eradicating the disease to attempt restoration to normalcy. This literature review aims to describe the physiology of the vaccines and how the spike protein is used as a target to elicit an antibody-dependent immune response in humans. Furthermore, the overview, dosing strategies, efficacy, and side effects will be discussed for the notable vaccines: BioNTech/Pfizer, Moderna, AstraZeneca, Janssen, Gamaleya, and SinoVac. In addition, the development of other prominent COVID-19 vaccines will be highlighted alongside the sustainability of the vaccine-mediated immune response and current contraindications. As the research is rapidly expanding, we have looked at the association between pregnancy and COVID-19 vaccinations, in addition to the current reviews on the mixing of vaccines. Finally, the prominent emerging variants of concern are described, and the efficacy of the notable vaccines toward these variants has been summarized.
format	article
author	Charles Yap Abulhassan Ali Amogh Prabhakar Akul Prabhakar Aman Pal Ying Yi Lim Pramath Kakodkar
author_facet	Charles Yap Abulhassan Ali Amogh Prabhakar Akul Prabhakar Aman Pal Ying Yi Lim Pramath Kakodkar
author_sort	Charles Yap
title	Comprehensive literature review on COVID-19 vaccines and role of SARS-CoV-2 variants in the pandemic
title_short	Comprehensive literature review on COVID-19 vaccines and role of SARS-CoV-2 variants in the pandemic
title_full	Comprehensive literature review on COVID-19 vaccines and role of SARS-CoV-2 variants in the pandemic
title_fullStr	Comprehensive literature review on COVID-19 vaccines and role of SARS-CoV-2 variants in the pandemic
title_full_unstemmed	Comprehensive literature review on COVID-19 vaccines and role of SARS-CoV-2 variants in the pandemic
title_sort	comprehensive literature review on covid-19 vaccines and role of sars-cov-2 variants in the pandemic
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/0e4d001fcbf7468aac67f37b064bf789
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Comprehensive literature review on COVID-19 vaccines and role of SARS-CoV-2 variants in the pandemic

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